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127294-77-3

3-Methylaminopiperidine dihydrochloride

CAS: 127294-77-3

Molecular Formula: C6H16Cl2N2

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127294-77-3 - Names and Identifiers

Name 3-Methylaminopiperidine dihydrochloride
Synonyms 3-Methylaminopiperidine2HCl
3-AMinoMethylpiperidine 2HCl
3-Methylaminopiperidine·2HCl
3-METHYLAMINO-PIPERIDINE DIHCL
3-A two-aMino-piperidine hydrochloride
3-Methylaminopiperidine dihydrochloride
3-Methylamino Piperidine Dihydrochloride
3-Methylamino-piperidine dihydrochloride
N-Methyl-3-Piperidinaminedihydrochloride
3-METHYLAMINO-PIPERIDINE DIHYDROCHLORIDE
N-Methylpiperidin-3-aMine dihydrochloride
3-(Methylamino)piperidine dihydrochloride
CAS 127294-77-3
EINECS 691-509-2
InChI InChI=1/C6H14N2.2ClH/c1-7-6-3-2-4-8-5-6;;/h6-8H,2-5H2,1H3;2*1H

127294-77-3 - Physico-chemical Properties

Molecular FormulaC6H16Cl2N2
Molar Mass187.11
Melting Point199-200°C
Boling Point253.7°C at 760 mmHg
Flash Point107.2°C
Water SolubilitySoluble in water
Vapor Presure0.0143mmHg at 25°C
AppearanceCrystalline powder
ColorWhite to Almost white
Storage ConditionSealed in dry,Room Temperature
MDLMFCD00673143
Physical and Chemical PropertiesMelting Point: 199-200°C

127294-77-3 - Risk and Safety

Risk Codes36/38 - Irritating to eyes and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
HS Code29333990

127294-77-3 - Reference Information

Overview 3-methylamine piperidine (1) is an important intermediate for the synthesis of fluoroquinolone antibacterial drug balofloxacin (balofloxacin). The literature uses γ-butyrolactone as raw material, 3-methylamine piperidine was obtained by amination, hydrolysis, esterification, condensation with ethyl bromoacetate, cyclization, ester hydrolysis and decarboxylation, reductive amination and hydrogen release of benzyl, etc., with long steps and low total yield (only 11.5%). 3-methylaminopyridine (4) was prepared by formylation and reduction of lithium aluminum hydride with 3-aminopyridine (2); or 2 was condensed with triethyl orthoformate and reduced with sodium borohydride to obtain 4,4 and then Pd/C reduction to obtain 3-methylaminopyridine diacetate with total yields of 16% and 32%, respectively.
Last Update:2024-04-09 15:16:47
127294-77-3
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Email: xuli678323@126.com
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Shanghai Yuanye Bio-Technology Co., Ltd.
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CAS: 127294-77-3
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