126162-38-7
2,3-Difluoro-4-hydroxybenzonitrile
CAS: 126162-38-7
Molecular Formula: C7H3F2NO
126162-38-7 - Names and Identifiers
126162-38-7 - Physico-chemical Properties
| Molecular Formula | C7H3F2NO |
| Molar Mass | 155.1 |
| Density | 1.44±0.1 g/cm3(Predicted) |
| Melting Point | 145-147 |
| Boling Point | 260.8±40.0 °C(Predicted) |
| Appearance | White to pink powder |
| pKa | 5.60±0.23(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| MDL | MFCD00269596 |
126162-38-7 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 3439 |
| Hazard Class | IRRITANT |
126162-38-7 - Reference Information
| Application | 2, 3-difluoro-4-cyanophenol can be used as an intermediate in pharmaceutical synthesis, and 2, 3-difluorophenyl can be used as a reaction The raw material reacts with N-formaldehyde piperidine to prepare the intermediate 4-ethoxy-2, 3-difluorobenzaldehyde, further react with hydroxylamine-O-sulfonic acid to prepare the intermediate 4-ethoxy-2, 3-difluorobenzonitrile, and then react with aluminum chloride to prepare. |
| preparation | a)4-ethoxy -2,3-difluorobenzaldehyde -78 ℃ to 400ml of tetrahydrofuran solution 125ml,0.2mol of n-butyllihexane solution, 0.2mol of 2, 3-difluorophenyl, 0.2mol of tetramethylenediamine, stirring the mixture at 70 ℃ and keeping at -60 ℃ for 2 hours, A mixture of 0.2mol of N-formaldehyde piperidine and 20ml of tetrahydrofuran was added dropwise to the mixture, warmed to -20°C and treated routinely to obtain 4-ethoxy-2, 3-difluorobenzaldehyde, a colorless solid, mp70 °C. B) A mixture of 0.12mol hydroxylamine-O-sulfonic acid and 50ml of water was added to a mixture of 0.1 mol-4-ethoxy-2, 3-difluorobenzaldehyde and 100ml of water at 30°C, and the mixture was stirred for 1 hour. After heating at 65°C for 2 hours and conventional treatment, a colorless solid 4-ethoxy-2, 3-difluorobenzonitrile, mp45 °C was obtained. c) 2,3-difluoro-4-cyanophenol A mixture of 0.1 moles of 4-ethoxy-2, 3-difluorobenzonitrile, 0.12 moles of aluminum chloride and 150ml of toluene is heated at the boiling point for 2 hours, and 2, 3-difluoro-4-cyanophenol is obtained by conventional treatment, which is a colorless solid, mp145 ℃. |
Last Update：2024-04-09 15:16:47
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126162-38-7
正十四酰氯
对甲苯酰氯
路路通内酯
ethyl 2-methylcrotonate
L-Valine solution hydrochloride
15621-57-5
Phosphorodichloridothioic acid phenyl ester
3,5-DIFLUOROCINNAMIC ACID
147284-02-4
正十四酰氯
对甲苯酰氯
路路通内酯
ethyl 2-methylcrotonate
L-Valine solution hydrochloride
15621-57-5
Phosphorodichloridothioic acid phenyl ester
3,5-DIFLUOROCINNAMIC ACID
147284-02-4