124655-09-0

124655-09-0 - Names and Identifiers

Name	T-butyl-(3R,5S)-6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate
Synonyms	D-6 rosuvastatin intermediatesC-5 Rosuvastatin calcium intermediate C-2 Tert-Butyl[(4R,6R)-6-Hydroxymethyl-1,3-Dioxan-4-Yl]Acetate tert-butyl 2,4-dideoxy-3,5-O-(1-methylethylidene)-D-erythro-hexonate T-BUTYL-(3R,5S)-6-HYDROXY 3,5-O-ISOPROPYLIDENE 3,5-DIHYDROXYHEXANOATE T-butyl-(3R,5S)-6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate tert-Butyl(4R-cis)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate tert-Butyl (4R,6S)-6-(Hydroxymethyl)-2,2-dimethyl-1,3-dioxane-4-acetate TERT-BUTYL (3R,5S)-6-HYDROXY 3,5-O-ISOPROPYLIDENE-3,5-DIHYDROXYHEXANOATE tert-Butyl(3R,5S)-6-hydroxy-3,5-O-iso-propylidene-3,5-dihydroxyhexanoate TERT-BUTYL [(4R,6S)-6-(HYDROXYMETHYL)-2,2-DIMETHYL-1,3-DIOXANE-4-YL] ACETATE (6S-Hydroxymethyl-2,2-dimethyl-[1,3]dioxan-4R-yl)acetic acid tert-butyl ester 2-[(4r,6s)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert-butyl ester (4R-Cis)-6-Hydroxymethyl-2,2-Dimethyl-1,3-Dioxane-4-Acetic Acid,1,1-Dimethylethyl Ester (4R-cis)-6-Hydroxymethyl-2, 2-dimethyl-1,3-dioxane-4-aceticacid,1,1-dimethylethyl ester (4R-Cis)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester D-erythro-Hexonic acid, 2,4-dideoxy-3,5-O-(1-methylethylidene)-, 1,1-dimethylethyl ester D-6 (4R-Cis)-6-HydroxyMethyl-2,2-DiMethyl-1,3-Dioxane-4-AceticAcid,1,1-DiMethylthylEster
CAS	124655-09-0
EINECS	432-960-5
InChI	InChI=1/C13H24O5/c1-12(2,3)18-11(15)7-9-6-10(8-14)17-13(4,5)16-9/h9-10,14H,6-8H2,1-5H3/t9-,10+/m1/s1
InChIKey	CFRUAOXMCVQMFP-ZJUUUORDSA-N

124655-09-0 - Physico-chemical Properties

Molecular Formula	C13H24O5
Molar Mass	260.33
Density	1.030
Boling Point	331°C
Flash Point	113°C
Solubility	Chloroform (Slightly), Methanol (Slightly)
Vapor Presure	0mmHg at 25°C
Appearance	Oil
Color	Pale Yellow to Brown to Thick
pKa	14.25±0.10(Predicted)
Storage Condition	Inert atmosphere,2-8°C
Refractive Index	1.4500-1.4540

124655-09-0 - Risk and Safety

HS Code

29329990

124655-09-0 - Introduction

(4R-Cis)-tert-butyl 6-hydroxymethyl-2,2-dimethyl-1, 3-dioxane-4-acetate, often abbreviated as Tertbutyl 6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-carboxylate.

Nature:
-Appearance: colorless liquid
-Molecular formula: C14H26O5
-Solubility: Soluble in common organic solvents such as ethers, alcohols and esters
-Melting Point/Boiling Point: No Report
-Relative density: no report
-Stability: stable, avoid contact with strong oxidants and high temperatures

Use:
- (4R-Cis)-6-hydroxymethyl-2, 2-dimethyl-1, 3-dioxane-4-acetic acid tert-butyl ester is commonly used as a chiral intermediate for the synthesis of a variety of compounds and drugs.
-It can be used as a protecting group in organic synthesis to provide protection for hydroxyl groups.
-It can also be used for asymmetric catalytic reactions in drug synthesis and synthesis of chiral drugs.

Preparation Method:
The specific preparation method can integrate multi-step reactions. One common preparation is by reacting 1,4-cyclohexanediol with tert-butyryl chloride to give a tert-butyrate compound, which is then converted to (4R-Cis)-6-hydroxymethyl-2, 2-dimethyl-1, 3-dioxane-4-acetic acid tert-butyl ester by photochemical hydroxymethylation.

Safety Information:
- (4R-Cis)-6-hydroxymethyl-2, 2-dimethyl-1, 3-dioxane-4-acetic acid tert-butyl ester specific safety information may vary from manufacturer to supplier, please refer to the relevant safety technical instructions and instructions when using.
-Wear appropriate personal protective equipment such as chemical goggles, protective gloves and protective clothing when used.
-Avoid contact with skin, eyes and respiratory tract. In case of contact or aspiration, rinse immediately with water and seek medical advice.
-During use and storage, please follow the correct operation and storage requirements of chemicals, avoid mixed storage with other chemicals, and keep away from fire and heat sources.

Last Update：2024-04-09 19:05:46