124236-37-9
5-TRIFLUOROMETHYL-PYRIDINE-2-CARBOXYLICACIDMETHYLESTER
CAS: 124236-37-9
Molecular Formula: C8H6F3NO2
124236-37-9 - Names and Identifiers
124236-37-9 - Physico-chemical Properties
| Molecular Formula | C8H6F3NO2 |
| Molar Mass | 205.13 |
| Density | 1.331±0.06 g/cm3(Predicted) |
| Boling Point | 248.0±40.0 °C(Predicted) |
| Flash Point | 103.8°C |
| Vapor Presure | 0.0249mmHg at 25°C |
| pKa | -0.73±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.446 |
124236-37-9 - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
124236-37-9 - Introduction
Methyl 5-trifluoromethylpyridine-2-carboxylate, also known as TFP ester, is an organic compound. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: colorless liquid
-Molecular formula: C8H4F3NO2
-Molecular weight: 205.12g/mol
-Density: 1.374 g/mL
-Boiling Point: 164-165°C
Use:
- TFP esters are widely used in organic synthesis and pharmaceutical research. It is an effective aromatic group protecting reagent, which can be used to protect amino group, hydroxyl group and thioether group.
-It can be used as a pharmaceutical intermediate for the synthesis of organic compounds containing trifluoromethyl groups.
-In addition, TFP ester can also be used for the synthesis of amide compounds, and is widely used in chemical, pharmaceutical and pesticide research for ester exchange reactions and amino protection.
Preparation Method:
- TFP esters can be prepared by reacting trifluoromethylpyridine with methyl 2-formate. The reaction usually takes place at room temperature and the desired product can be purified by distillation.
Safety Information:
- TFP ester is considered safe under normal conditions of use. However, as an organic compound, it has a certain potential danger.
-Direct contact with skin and eyes may cause irritation or injury. Therefore, care should be taken to wear appropriate protective equipment such as gloves and goggles during use.
-In addition, TFP ester should also be kept away from fire and high temperature to avoid possible fire or explosion.
For more specific use and safety information, please consult the relevant chemical literature or consult a professional.
Nature:
-Appearance: colorless liquid
-Molecular formula: C8H4F3NO2
-Molecular weight: 205.12g/mol
-Density: 1.374 g/mL
-Boiling Point: 164-165°C
Use:
- TFP esters are widely used in organic synthesis and pharmaceutical research. It is an effective aromatic group protecting reagent, which can be used to protect amino group, hydroxyl group and thioether group.
-It can be used as a pharmaceutical intermediate for the synthesis of organic compounds containing trifluoromethyl groups.
-In addition, TFP ester can also be used for the synthesis of amide compounds, and is widely used in chemical, pharmaceutical and pesticide research for ester exchange reactions and amino protection.
Preparation Method:
- TFP esters can be prepared by reacting trifluoromethylpyridine with methyl 2-formate. The reaction usually takes place at room temperature and the desired product can be purified by distillation.
Safety Information:
- TFP ester is considered safe under normal conditions of use. However, as an organic compound, it has a certain potential danger.
-Direct contact with skin and eyes may cause irritation or injury. Therefore, care should be taken to wear appropriate protective equipment such as gloves and goggles during use.
-In addition, TFP ester should also be kept away from fire and high temperature to avoid possible fire or explosion.
For more specific use and safety information, please consult the relevant chemical literature or consult a professional.
Last Update：2024-04-09 20:52:54
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