122384-88-7

122384-88-7 - Names and Identifiers

Name	Diabetes Associated Peptide Amide human
Synonyms	DAP DAP (HUMAN) AMYLIN, HUMAN DAP AMIDE, HUMAN DIABETES-ASSOCIATED PEPTIDE HUMAN DIABETES ASSOCIATED PEPTIDE AMIDE HUMAN Diabetes Associated Peptide Amide human DIABETES-ASSOCIATED PEPTIDE (DAP) AMIDE, HUMAN LYS-CYS-ASN-THR-ALA-THR-CYS-ALA-THR-GLN-ARG-LEU-ALA-ASN-PHE-LEU-VAL-HIS-SER-SER-ASN-ASN-PHE-GLY-ALA-ILE-LEU-SER-SER-THR-ASN-VAL-GLY-SER-ASN-THR-TYR-NH2
CAS	122384-88-7

122384-88-7 - Physico-chemical Properties

Molecular Formula	C8H17O3*
Molar Mass	161.21878
Water Solubility	Soluble to 5 mg/ml in water and in 5% acetic acid.
Appearance	White powder
Storage Condition	-20°C
MDL	MFCD00081345
In vitro study	MCF-7 cells endogenously express human amylin receptor CTR1 and CTR2. Stimulation of the receptor with Amylin, amide, human results in the production of cAMP. Amylin, amide, human (0.001 nM-1000 μM) results in an EC 50 of 35.2±7.5 nM. Cell Viability Assay Cell Line: MCF-7 cells Concentration: 0.001 nM, 0.01 nM, 0.1 nM, 1 nM, 10 nM, 100 nM, 1 μM, 10μM, 100 μM, 1000 μM Incubation Time: Result: Resulted in the production of cAMP with an EC 50 of 35.2±7.5 nM.
In vivo study	Amylin, amide, human (400 μg peptide /kg body weight) is injected by subcutaneous route in separated groups of swiss male mice. A typical PK curve for the free amylin is observed, with a half-time of 23 min. Animal Model: Swiss male mice (8 weeks old) Dosage: 400 μg peptide /kg body weight (Pharmacokinetic Analysis) Administration: Subcutaneous route; 24 hours Result: Half-time of 23 min.

122384-88-7 - Risk and Safety

WGK Germany

122384-88-7 - Introduction

Amino acid sequence Lys-Cys-Asn-Thr-Ala-Thr-C?ys-Ala-Thr-Gln-Arg-Leu-Al?a-Asn-Phe-Leu-Val-His-Ser?-Ser-Asn-Asn-Phe-Gly-Ala-?Ile-Leu-Ser-Ser-Thr-Asn-V?al-Gly-Ser-Asn-Thr-Tyr-NH?2

Last Update：2022-10-16 17:41:21

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