1216658-90-0
1-(4-fluorophenyl)cyclobutan-1-amine hydrochloride
CAS: 1216658-90-0
Molecular Formula: C10H13ClFN
1216658-90-0 - Names and Identifiers
1216658-90-0 - Physico-chemical Properties
| Molecular Formula | C10H13ClFN |
| Molar Mass | 201.6683232 |
| Storage Condition | 2-8℃ |
1216658-90-0 - Introduction
1-(4-fluorophenyl)cyclobutan-1-amine is an organic compound with the chemical formula C10H13Fn∙ HCl. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: White crystalline solid
-Melting point: About 110-112 ° C
-Solubility: Soluble in water and some organic solvents, such as methanol, ethanol and ether.
Use:
1-(4-fluorophenyl)cyclobutan-1-amine has certain application value in drug research and manufacturing, and is often used as an intermediate. Some studies have shown that the compound has some potential biological activities and may be used in anti-anxiety, anti-depression or anti-tumor drug research.
Method:
The synthesis of 1-(4-fluorophenyl)cyclobutan-1-amine is usually carried out by the following steps:
-In the first step, 1,4-difluorobenzene and cyclobutanone are subjected to a reduction reaction for about 4 to 6 hours to form 1-(4-fluorophenyl) cyclobutanone. Reaction conditions may employ hydrogen and a catalyst, such as platinum or palladium.
-In the second step, 1-(4-fluorophenyl) cyclobutanone is reacted with an amine compound. Commonly used amines include ethylamine or methylamine. The reaction is usually carried out in ammonia solution. This step yields 1-(4-fluorophenyl) cyclobutan-1-amine.
-In the third step, hydrochloric acid is used to react with 1-(4-fluorophenyl)cyclobutan-1-amine to form 1-(4-fluorophenyl)cyclobutan-1-amine hydrochloride.
Safety Information:
- 1-(4-fluorophenyl)cyclobutan-1-amine hydrochloride is generally less toxic when used correctly.
-Since the specific use of the compound may involve the medical field, attention should be paid to complying with relevant regulations and safety operating guidelines.
-Good laboratory practices should be followed when handling the compound, and appropriate personal protective equipment (such as lab gloves, goggles, and lab coats) should be worn.
-If detailed toxicity data and safe handling information are not available, it is recommended that you consult your laboratory or relevant chemical supplier when using this compound.
Nature:
-Appearance: White crystalline solid
-Melting point: About 110-112 ° C
-Solubility: Soluble in water and some organic solvents, such as methanol, ethanol and ether.
Use:
1-(4-fluorophenyl)cyclobutan-1-amine has certain application value in drug research and manufacturing, and is often used as an intermediate. Some studies have shown that the compound has some potential biological activities and may be used in anti-anxiety, anti-depression or anti-tumor drug research.
Method:
The synthesis of 1-(4-fluorophenyl)cyclobutan-1-amine is usually carried out by the following steps:
-In the first step, 1,4-difluorobenzene and cyclobutanone are subjected to a reduction reaction for about 4 to 6 hours to form 1-(4-fluorophenyl) cyclobutanone. Reaction conditions may employ hydrogen and a catalyst, such as platinum or palladium.
-In the second step, 1-(4-fluorophenyl) cyclobutanone is reacted with an amine compound. Commonly used amines include ethylamine or methylamine. The reaction is usually carried out in ammonia solution. This step yields 1-(4-fluorophenyl) cyclobutan-1-amine.
-In the third step, hydrochloric acid is used to react with 1-(4-fluorophenyl)cyclobutan-1-amine to form 1-(4-fluorophenyl)cyclobutan-1-amine hydrochloride.
Safety Information:
- 1-(4-fluorophenyl)cyclobutan-1-amine hydrochloride is generally less toxic when used correctly.
-Since the specific use of the compound may involve the medical field, attention should be paid to complying with relevant regulations and safety operating guidelines.
-Good laboratory practices should be followed when handling the compound, and appropriate personal protective equipment (such as lab gloves, goggles, and lab coats) should be worn.
-If detailed toxicity data and safe handling information are not available, it is recommended that you consult your laboratory or relevant chemical supplier when using this compound.
Last Update：2024-04-09 15:18:04
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