120578-03-2
3-(2-(7-Chloroquinoline-2-yl)-(E)-vinyl)benzaldehyde
CAS: 120578-03-2
Molecular Formula: C18H12ClNO
120578-03-2 - Names and Identifiers
120578-03-2 - Physico-chemical Properties
| Molecular Formula | C18H12ClNO |
| Molar Mass | 293.75 |
| Density | 1.313±0.06 g/cm3(Predicted) |
| Melting Point | 149-153oC |
| Boling Point | 476.5±33.0 °C(Predicted) |
| Flash Point | 241.98°C |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Solid |
| Color | Pale Beige to Light Brown |
| pKa | 2.09±0.61(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.751 |
120578-03-2 - Introduction
(E)-3-[2-(7-Chloro-2-quinolinyl) vinyl] benzaldehyde, also known as 7-chloro-2-quinolinylacrylic acid benzaldehyde, is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: Common white to light yellow crystalline solid.
-Molecular formula: C16H11ClNO.
-Molecular weight: 277.72g/mol.
-Melting point: about 80-85 ℃.
-Boiling point: about 480-490 ℃.
-Low solubility in water, but soluble in organic solvents such as ether, acetone, etc.
Use:
(E)-3-[2-(7-chloro-2-quinolinyl) vinyl] benzaldehyde is an important pharmaceutical intermediate, which is commonly used in the synthesis of drugs, especially with antibacterial, antiviral and anti-cancer activity.
Preparation Method:
The method for producing (E)-3-[2-(7-chloro-2-quinolyl) vinyl] benzaldehyde can be carried out by the following steps:
1. First, 7-chloro-2-quinolinamine is reacted with acrolein to produce 7-chloro-2-quinolinylacrolein.
2. Next, 2-aminopyridine is reacted with benzaldehyde to produce 2-aminopyridyl benzaldehyde.
3. Finally, the products of step 1 and step 2 are subjected to hydrogenation-reduction reaction to obtain (E)-3-[2-(7-chloro-2-quinolyl) vinyl] benzaldehyde.
Safety Information:
(E)-3-[2-(7-Chloro-2-quinolyl) vinyl] benzaldehyde The following safety precautions should be taken during use and storage:
-The compound is irritating and toxic and must be handled carefully.
-Avoid contact with skin, eyes and mucous membranes during operation, and wear protective gloves and glasses if necessary.
-It should be operated in a well-ventilated place to avoid inhaling its vapor.
-Storage should be sealed and kept away from fire and oxidizing agents.
-If inhaled or exposed, rinse the affected area immediately with water and seek medical help.
Nature:
-Appearance: Common white to light yellow crystalline solid.
-Molecular formula: C16H11ClNO.
-Molecular weight: 277.72g/mol.
-Melting point: about 80-85 ℃.
-Boiling point: about 480-490 ℃.
-Low solubility in water, but soluble in organic solvents such as ether, acetone, etc.
Use:
(E)-3-[2-(7-chloro-2-quinolinyl) vinyl] benzaldehyde is an important pharmaceutical intermediate, which is commonly used in the synthesis of drugs, especially with antibacterial, antiviral and anti-cancer activity.
Preparation Method:
The method for producing (E)-3-[2-(7-chloro-2-quinolyl) vinyl] benzaldehyde can be carried out by the following steps:
1. First, 7-chloro-2-quinolinamine is reacted with acrolein to produce 7-chloro-2-quinolinylacrolein.
2. Next, 2-aminopyridine is reacted with benzaldehyde to produce 2-aminopyridyl benzaldehyde.
3. Finally, the products of step 1 and step 2 are subjected to hydrogenation-reduction reaction to obtain (E)-3-[2-(7-chloro-2-quinolyl) vinyl] benzaldehyde.
Safety Information:
(E)-3-[2-(7-Chloro-2-quinolyl) vinyl] benzaldehyde The following safety precautions should be taken during use and storage:
-The compound is irritating and toxic and must be handled carefully.
-Avoid contact with skin, eyes and mucous membranes during operation, and wear protective gloves and glasses if necessary.
-It should be operated in a well-ventilated place to avoid inhaling its vapor.
-Storage should be sealed and kept away from fire and oxidizing agents.
-If inhaled or exposed, rinse the affected area immediately with water and seek medical help.
Last Update：2024-04-09 21:01:54
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Tel: 0712-8899838
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Product Name: (E)-3-(2-(7-Chloroquinolin-2-yl)vinyl)benzaldehyde Request for quotationCAS: 120578-03-2
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CAS: 120578-03-2
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View History
120578-03-2
38049-26-2
50743-02-7
24186-66-1
硬脂酰肼
九胜肽-9
Perhydroa-zocine
benzyl acetater
1491136-22-1
AKOS BBS-00000687
38049-26-2
50743-02-7
24186-66-1
硬脂酰肼
九胜肽-9
Perhydroa-zocine
benzyl acetater
1491136-22-1
AKOS BBS-00000687