1199773-24-4
1-(3-Bromo-5-fluorophenyl)pyrrolidine
CAS: 1199773-24-4
Molecular Formula: C10H11BrFN
1199773-24-4 - Names and Identifiers
1199773-24-4 - Physico-chemical Properties
| Molecular Formula | C10H11BrFN |
| Molar Mass | 244.1 |
| Density | 1.485±0.06 g/cm3(Predicted) |
| Boling Point | 315.3±32.0 °C(Predicted) |
| pKa | 5.68±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | IRRITANT |
| MDL | MFCD13195637 |
1199773-24-4 - Reference Information
| Overview | 1-bromo-3-fluoro-5-pyrrolidinobenzene is a pharmaceutical intermediate, it can be prepared by nucleophilic substitution of 1-bromo-3, 5-difluorobenzene with pyrrolidine. |
| Application | 1-bromo-3-fluoro-5-pyrrolidine benzene can be used to prepare phenyl (4-(3-(pyrrolidin-1-yl))-5-fluorophenyl]) piperazine-l-yl) methanone, an anti-amyloid compound. |
| Use | 1-bromo-3-fluoro-5-pyrrolidine benzene is a pharmaceutical intermediate, it can be prepared by nucleophilic substitution of 1-bromo-3, 5-difluorobenzene with pyrrolidine. 1-bromo-3-fluoro-5-pyrrolidine benzene is useful in the preparation of phenyl (4-(3-(pyrrolidin-1-yl)-5-fluorophenyl]) piperazine-l-yl) methanone, an anti-amyloid compound. |
| preparation | 1-bromo-3, 5-difluorobenzene (1.00g,5.18mmol), pyrrolidine (0.47mL,5.7mmol),DEPEA(1.4mL,7.77mmol) and NMP(6.9mL) were added to the tube. The tube was sealed and stirred at 100 °c overnight. The reaction mixture was diluted with water and EtOAc. The aqueous layer was back-extracted with EtOAc (3x). The combined organic layers were then washed with H2O,1N HCl(2x), saturated NaHCO3,H2O and brine and then dried over Na2SO4. The material was filtered and concentrated under reduced pressure to give 1.178g of a solid, crude yellow solid. |
Last Update：2024-04-10 22:29:15
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Product Name: 1-(3-Bromo-5-fluorophenyl)pyrrolidine Visit Supplier Webpage Request for quotationCAS: 1199773-24-4
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Product Name: 1-Bromo-3-fluoro-5-pyrrolidinobenzene Visit Supplier Webpage Request for quotationCAS: 1199773-24-4
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View History
1199773-24-4
吉非替尼盐酸盐
172705-25-8
2,2'-羟基偶氮苯
二乙基氨基乙腈
13597-46-1
PantoprozoleSodium
174634-09-4
7-Azidoheptanoic acid Methyl ester
2-CHLORO-5-FLUOROPYRIDINE
吉非替尼盐酸盐
172705-25-8
2,2'-羟基偶氮苯
二乙基氨基乙腈
13597-46-1
PantoprozoleSodium
174634-09-4
7-Azidoheptanoic acid Methyl ester
2-CHLORO-5-FLUOROPYRIDINE