1196109-52-0
PF-3845
CAS: 1196109-52-0
Molecular Formula: C24H23F3N4O2
1196109-52-0 - Names and Identifiers
1196109-52-0 - Physico-chemical Properties
| Molecular Formula | C24H23F3N4O2 |
| Molar Mass | 456.46 |
| Density | 1.323±0.06 g/cm3(Predicted) |
| Boling Point | 623.6±55.0 °C(Predicted) |
| Solubility | Soluble in DMSO (100 mM), ethanol (~20 mg/ml), DMF (~20 mg/ml), 1:3 EtOH:PBS(pH 7.2) ( |
| Appearance | White to Brown Powder |
| Color | white to tan |
| pKa | 14.14±0.40(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD21365072 |
| Use | A selective fatty acid amide hydrolase (FAAH) inhibitor. |
| In vitro study | PF-3845 (0.5 nM-10 μM; 40 min) inhibits human FAAH-1 (IC 50 =18 nM) in a concentration-dependent manner, and shows negligible activity against FAAH-2 (IC 50 >10 μM) in COS-7 cells. PF-3845 (0.1-1000 μM; 48 h) significantly decreases the Colo-205 cell viability. |
| In vivo study | PF-3845 (1-30 mg/kg; p.o.) produces cannabinoid receptor-dependent reductions in inflammatory pain in rat. PF-3845 (10 mg/kg; a single i.p.) selectively inhibits FAAH in mice for up to 24 hours. PF-3845 (10 mg/kg; a single i.p.) causes a dramatic and sustained elevation in Anandamide (AEA) in mice. Animal Model: Male Sprague-Dawley rats (200g- 250g) are injected CFA Dosage: 1, 3, 10, 30 mg/kg Administration: Oral administration Result: Caused a dose-dependent inhibition of mechanical allodynia with a minimum effective dose (MED) of 3 mg/kg. |
1196109-52-0 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
1196109-52-0 - Introduction
PF-3845 is an effective, selective and irreversible FAAH inhibitor with Ki of 230 nM and little activity against FAAH2.
Last Update：2022-10-16 17:41:19
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