1185763-69-2
NVP-BVU972
CAS: 1185763-69-2
Molecular Formula: C20H16N6
1185763-69-2 - Names and Identifiers
1185763-69-2 - Physico-chemical Properties
| Molecular Formula | C20H16N6 |
| Molar Mass | 340.38 |
| Density | 1.35 |
| pKa | 4.92±0.10(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | NVP-BVU972 efficient inhibition of MET kinase, while inhibition of other kinases, including the most closely related kinase RON, was very low, with an IC50 above 1000 nM. NVP-BVU972, it inhibited constitutive MET phosphorylation in GTL-16 cells, and inhibited HGF-stimulated MET phosphorylation in A549 cells, with IC50 of 7.3 and 22 nM, respectively. Cell lines that potently inhibited the proliferation of the MET gene by NVP-BVU972, GTL-16 and MKN-45 grew at IC50 of 66, 82 and 32 nM, respectively. NVP-BVU972 acting on BaF3 cells, Y1230 and D1228 mutations cause a dramatic change in the measured IC50. The resistance induced by V1155L is limited by NVP-BVU972. The effect of NVP-BVU972 on BaF3 cells expressing wild-type TPR-MET decreased phosphorylation by TPR-MET in a dose-dependent manner. Y1230H and D1228A mutations abrogate the effect of NVP-BVU972 but not AMG 458. However, F1200I and L1195V interference NVP-BVU972 inhibited TPR-MET phosphorylation. |
1185763-69-2 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.938 ml | 14.689 ml | 29.379 ml |
| 5 mM | 0.588 ml | 2.938 ml | 5.876 ml |
| 10 mM | 0.294 ml | 1.469 ml | 2.938 ml |
| 5 mM | 0.059 ml | 0.294 ml | 0.588 ml |
Last Update：2024-01-02 23:10:35
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View History
1185763-69-2
1,1-二氯丙酮
DMT Sulfobetaine
陶瓷氧化铝空心球
5-甲基四氢叶酸钙
磷甲酸钠 标准品
美沙拉嗪杂质18
PHENYLVINYLDIMETHOXYSILANE
Tatrabromophthalic anhydride
3-Propanediol,2-methyl-1
1,1-二氯丙酮
DMT Sulfobetaine
陶瓷氧化铝空心球
5-甲基四氢叶酸钙
磷甲酸钠 标准品
美沙拉嗪杂质18
PHENYLVINYLDIMETHOXYSILANE
Tatrabromophthalic anhydride
3-Propanediol,2-methyl-1