1174046-72-0
BMS-794833
CAS: 1174046-72-0
Molecular Formula: C23H15ClF2N4O3
1174046-72-0 - Names and Identifiers
1174046-72-0 - Physico-chemical Properties
| Molecular Formula | C23H15ClF2N4O3 |
| Molar Mass | 468.84 |
| Density | 1.508 |
| Boling Point | 637.2±55.0 °C(Predicted) |
| pKa | 8.79±0.69(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | BMS794833 also inhibited Met receptor-activated gastric cancer cell line GTL-16 with an IC50 of 39 nM. BMS794833 also inhibited Met receptor-activated gastric cancer cell line GTL-16 with an IC50 of 39 nM. |
| In vivo study | BMS798433 treatment of human gastric xenograft model GTL-16 cell line for 14 days showed no significant cytotoxicity and tumor growth inhibition of more than 50% per tumor. BMS798433 acted on the malignant glioma model U87 and treated 25mg of BMS798433 per kg of animal body weight, which showed that the tumor completely stopped growing. BMS798433 treatment of human gastric xenograft model GTL-16 cell line for 14 days showed no significant cytotoxicity and tumor growth inhibition rate was more than 50% per tumor. BMS798433 acted on the malignant glioma model U87 and treated 25mg of BMS798433 per kg of animal body weight, which showed that the tumor completely stopped growing. |
1174046-72-0 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.133 ml | 10.665 ml | 21.329 ml |
| 5 mM | 0.427 ml | 2.133 ml | 4.266 ml |
| 10 mM | 0.213 ml | 1.066 ml | 2.133 ml |
| 5 mM | 0.043 ml | 0.213 ml | 0.427 ml |
Last Update：2024-01-02 23:10:35
1174046-72-0 - Reference Information
| biological activity | BMS-794833 is an effective ATP competitive Met/VEGFR2 inhibitor, IC50 is 1.7 nM/15 nM, also inhibits Ron, Axl and Flt3,IC50 is lower than 3 nM; It is a BMS-817378 precursor drug. Phase 1. BMS-794833 is an effective ATP competitive Met (c-Met)/VEGFR2 inhibitor with IC50 of 1.7 nM/15 nM, also inhibiting Ron, Axl and Flt3,IC50 lower than 3 nM; It is a BMS-817378 prodrug. Phase 1. |
| in vitro study | BMS794833 also inhibited Met receptor activated gastric cancer cell line GTL-16 with IC50 of 39 nM. BMS794833 also inhibited Met receptor activated gastric cancer cell line GTL-16 with IC50 of 39 nM. |
| in vivo study | BMS798433 treated the GTL-16 cell line of human gastric transplant tumor model for 14 days without obvious cytotoxicity, and the tumor growth inhibition rate in each tumor reached more than 50%. BMS798433 acted on U87 malignant glioma model and treated 25mg BMS798433 per kilogram according to animal weight. The results showed that the tumor completely stopped growing. BMS798433 treatment of human gastric transplanted tumor model GTL-16 cell lines for 14 days without obvious cytotoxicity, and the tumor growth inhibition rate in each tumor reached more than 50%. BMS798433 acted on U87, a malignant glioma model, BMS798433 25mg per kilogram according to animal weight. The results showed that the tumor completely stopped growing. |
| target | TargetValue Met 1.7 nM VEGFR2 15 nM |
| Target | Value |
| Met | 1.7 nM |
| VEGFR2 | 15 nM |
Last Update：2024-04-09 21:54:55
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View History
1174046-72-0
1803239-58-8
头孢曲松钠3.5水
p-menth-1-en
一缩二乙二醇一丁醚
3-bromo-4-methylbenzonitrile
烷基糖苷0810
1-环戊基-2-丙酮
1803239-58-8
头孢曲松钠3.5水
p-menth-1-en
一缩二乙二醇一丁醚
3-bromo-4-methylbenzonitrile
烷基糖苷0810
1-环戊基-2-丙酮