115841-09-3
Salvianolic acid C
CAS: 115841-09-3
Molecular Formula: C26H20O10
115841-09-3 - Names and Identifiers
115841-09-3 - Physico-chemical Properties
| Molecular Formula | C26H20O10 |
| Molar Mass | 492.43 |
| Density | 1.570 |
| Boling Point | 844.2±65.0 °C(Predicted) |
| Specific Rotation(α) | (c, 0.1 in EtOH)+70 |
| Solubility | Soluble in methanol and water, insoluble in petroleum ether. |
| Appearance | Yellow powder |
| pKa | 2.76±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Sensitive | Easily absorbing moisture |
| MDL | MFCD16660675 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Salvia miltiorrhiza. |
| In vitro study | Salvianolic acid C is a noncompetitive CYP2C8 inhibitor and a moderate mixed inhibitor of CYP2J2, with K i s of 4.82, 5.75 μM for CYP2C8 and CYP2J2, respectively. 1 and 5 μM Salvianolic acid C (SalC) could significantly inhibit the NO production induced by LPS. Salvianolic acid C decreases the expression of iNOS significantly. Salvianolic acid C inhibits LPS-induced TNF-α, IL-1β, IL-6 and IL-10 overproduction. Salvianolic acid C inhibits LPS-induced NF‑κB activation. Salvianolic acid C also increases the expression of Nrf2 and HO-1 in BV2 microglial cells. |
| In vivo study | Salvianolic acid C (20 mg/kg) treatment could significantly decrease the escape latency. In addition, SalC (10 and 20 mg/kg) treatment significantly increase the platform crossing number compared with the LPS model group. Systemic administration of Salvianolic acid C down regulates the brain TNF-α, IL-1β and IL-6 levels compared with the model group. The iNOS and COX-2 levels in rat brain cortex and hippocampus are higher than that in the control group, while Salvianolic acid C treatment significantly down regulates the cortex and hippocampus regions. Salvianolic acid C (5, 10 and 20 mg/kg) treatment dose-dependently increases the p-AMPK, Nrf2, HO-1 and NQO1 levels in rat brain cortex and hippocampus. |
115841-09-3 - Reference
| Reference Show more | 1. Cheng Pei, Han Dongqi, Hu Weihui, etc. Simultaneous determination of 10 water-soluble and 4 fat-soluble components in Salvia miltiorrhiza by high performance liquid chromatography [J]. Journal of Pharmaceutical Analysis, 2015(06):991-996. 2. Cui Weiliang, Li Huifen, Zhang Xuelan, et al. Analysis of 5 kinds of qualitative change compounds before and after wine processing of Danshen by UPLC-QE/MS [J]. Chinese patent medicine 2019 041(004):844-849. 3. Cui Weiliang. Comparison of the distribution of chromatographic peaks of HPLC fingerprint before and after the processing of Danshen wine [J]. Liaoning Journal of Traditional Chinese Medicine, v.46;No.507(08):1707-1709. 4. Li, X., zhao, X., shu, Z. et al. Phoma glomerata D14. Curr Microbiol 73, 31-37 (2016). https://doi.org/10.1007/s00284-016-1023-y 5. Wang, Yang, et al. "Identification of Salvia species using high‐performance liquid chromatography combined with chemical pattern recognition analysis." Journal of separation science 41.3 (2018): 609-617.https://doi.org/10.1002/jssc.201701066 6. Wang, Jixia, et al. "Discovery of new targets of phenolic acids in danshen using a label-free cell phenotypic assay ." RSC Advances 5.33 (2015): 25768-25776.https://doi.org/10.1039/C4RA16102E 7. [IF=4.759] Yanmei Zhang et al."Screening of mammalian target of rapamycin inhibitors in natural product extracts by capillary electrophoresis in combination with high performance liquid chromatography-tandem mass spectrometry."J Chromatogr A. 2015 Apr;1388:267 8. [IF=3.645] Yang Wang et al."Identification of Salvia species using high-performance liquid chromatography combined with chemical pattern recognition analysis."J Sep Sci. 2018 Feb;41(3):609-617 9. [IF=3.049] Jixia Wang et al."Discovery of new targets of phenolic acids in danshen using a label-free cell phenotypic assay."Rsc Adv. 2015 Mar;5(33):25768-25776 10. [IF=2.188] Li Xiuqing et al."Phoma glomerata D14: An Endophytic Fungus from Salvia miltiorrhiza That Produces Salvianolic Acid C."Curr Microbiol. 2016 Jul;73(1):31-37 11. [IF=6.475] Shi Qiu et al."Selection of appropriate post-harvest processing methods based on the metabolomics analysis of Salvia miltiorrhiza Bunge."Food Res Int. 2021 Jun;144:110366 12. [IF=3.361] Rong Wang et al."Resonant waveguide grating based assays for colloidal aggregate detection and promiscuity characterization in natural products."Rsc Adv. 2019 Nov;9(65):38055-38064 13. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 14. [IF=6.057] Qi Tong et al.Biosynthesis-based spatial metabolome of Salvia miltiorrhiza Bunge by combining metabolomics approaches with mass spectrometry-imaging.Talanta. 2021 Nov;:123045 15. [IF=7.848] Mingyue Zhou et al."Oriented Layered Graphene Oxide Pad Favoring High Loading Capacity and Stability for High-Throughput Chemical Screening."Advanced Materials Technologies. 2022 Mar 11 |
115841-09-3 - Reference Information
| Biological activity | Salvianolic acid C is a non-competitive inhibitor of cytochrome P4502C8 (CYP2C8) and a medium-strength mixed inhibitor of cytochrome P4502J2 (CYP2J2). Its Ki values for CYP2C8 and CYP2J2 are 4.82 μM and 5.75 μM, respectively. |
| target | CYP2C8 4.82 μM (Ki) CYP2J2 5.75 μM (Ki) |
| in vitro study | Salvianolic acid C is a noncompetitive CYP2C8 inhibitor and a moderate mixed inhibitor of CYP2J2, with K I s of 4.82, 5.75 μM for CYP2C8 and CYP2J2, respectively. 1 and 5 μM Salvianolic acid C (SalC) could significantly inhibit the NO production induced by LPS. Salvianolic acid C decreases the expression of iNOS significantly. Salvianolic acid C inhibits LPS-induced TNF-α, IL-1β, IL-6 and IL-10 overproduction. Salvianolic acid C inhibits LPS-induced NF-κB activation. Salvianolic acid C also increases the expression of Nrf2 and HO-1 in BV2 microglial cells. |
| in vivo study | Salvianolic acid C (20 mg/kg) treatment could significantly decrease the escape latency. In addition, SalC (10 and 20 mg/kg) treatment significantly increase the platform crossing number compared with the LPS model group. Systemic administration of Salvianolic acid C down regulates the brain TNF-α, IL-1β and IL-6 levels compared with the model group. The iNOS and COX-2 levels in rat brain cortex and hippocampus are higher than that in the control group, while Salvianolic acid C treatment significantly down regulates the cortex and hippocampus regions. Salvianolic acid C (5, 10 and 20 mg/kg) treatment dose-dependently increases the p-AMPK, Nrf2, HO-1 and NQO1 levels in rat brain cortex and hippocampus. |
| chemical properties | white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from salvia miltiorrhiza. |
| use | salvianolic acid C 1. it has obvious anti-platelet aggregation effect. 2. Free radical scavenger. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: It has certain antioxidant, protection of brain tissue cell damage, protection of cardiovascular and cerebrovascular system and anti-HIV effects. |
Last Update：2024-04-09 15:16:39
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View History
115841-09-3
131119-10-3
聚甲烯化合物
6-ISOPROPYLQUINOLINE
desferalmesylate
二乙基氰化铝 溶液
Hexamethylendiamine
1403667-44-6
α-MethylbenzeneMethanol
1225830-62-5
131119-10-3
聚甲烯化合物
6-ISOPROPYLQUINOLINE
desferalmesylate
二乙基氰化铝 溶液
Hexamethylendiamine
1403667-44-6
α-MethylbenzeneMethanol
1225830-62-5