| Molecular Formula | C17H14F2N2 |
| Molar Mass | 284.3 |
| Appearance | Off-white solid |
| Storage Condition | Store at RT |
| In vitro study | Golgi IDE A inhibits the effect of Shiga toxin on protein synthesis with an IC50 of 3.3 μm. Golgi IDE A causes A decrease in gbf1-mediated Arf1 activation, blocks soluble secretions and membrane-anchored proteins, and subsequently impairs degenerated toxin transport. In J6/JFH1 cells, Golgi IDE A caused NS5A redistribution and accumulation of Transmissibility Virus particles. |
| biological activity | Golgi IDE A is A potent, rapidly reversible GBF1 inhibitor. |
| in vitro study | Golgi IDE A inhibits the effects of Shiga toxin on protein synthesis with an IC50 of 3.3 μm. Golgi IDE A causes A decrease in gbf1-mediated Arf1 activation, blocks soluble secretions and membrane-anchored proteins, and subsequently impairs degenerated toxin transport. In J6/JFH1 cells, Golgi IDE A caused NS5A redistribution and accumulation of Transmissibility Virus particles. |
| Target | GBF1 |