106941-25-7
Adefovir
CAS: 106941-25-7
Molecular Formula: C8H12N5O4P
106941-25-7 - Names and Identifiers
| Name | Adefovir |
| Synonyms | PMEA Adefovir Adefovir(PMEA) treatment Adefovir 2-(6-amino-9h-purin- Adefovir dipivox (PMEA) Tenofovir Desmethyl Impurity 9-(2-phosphonylmethoxyethyl)adenine 9-[2-phosphonylmethoxyethyl]adenine 9-[2-(Phosphonomethoxy)ethyl]adenine(PMEA) 2-(6-amino-7H-purin-9-yl)ethoxymethylphosphonic acid 2-(6-amino-9h-purin-9-yl)ethoxy]methylphosphonic acid [[2-(6-AMino-9H-purin-9-yl)ethoxy] Methyl]phosponic Acid ((2-(6-amino-9h-purin-9-yl)ethoxy)methyl)-phosphonic aci {[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}phosphonic acid ((2-(6-amino-9h-purin-9-yl)ethoxy)methyl)phosphonic acid P-[[2-(6-AMino-9H-purin-9-yl)ethoxy]Methyl]phosphonic Acid [[2-(6-amino-9H-purin-9-yl) ethoxy] methyl] phosphoric acid |
| CAS | 106941-25-7 |
| EINECS | 600-789-7 |
| InChI | InChI=1/C8H13N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4,12H,1-2,5H2,(H2,9,10,11)(H2,14,15,16) |
| InChIKey | SUPKOOSCJHTBAH-UHFFFAOYSA-N |
106941-25-7 - Physico-chemical Properties
| Molecular Formula | C8H12N5O4P |
| Molar Mass | 273.19 |
| Density | 1.88 |
| Melting Point | >260°C |
| Boling Point | 632.5±65.0 °C(Predicted) |
| Solubility | 0.1 M NaOH: ≥5 mg/mL |
| Appearance | white to beige powder |
| Color | white to beige |
| pKa | pKa1 2.0, pKa2 6.8(at 25℃) |
| Storage Condition | -20°C |
| MDL | MFCD00866943 |
| Physical and Chemical Properties | Density 1.88 melting point> 260°C |
| Use | Used as an antiviral drug |
106941-25-7 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 2811 |
| WGK Germany | 3 |
| RTECS | SZ6563500 |
| HS Code | 29339900 |
| Hazard Class | 6.1 |
| Packing Group | Ⅲ |
106941-25-7 - Nature
Open Data Verified Data
white crystals were obtained from water. Melting point> 250 °c. UV maximum absorption (H20) 208,260nm & epsilon;(19600, 14100);(0.1 moi/L HCI)210, 260nm(e19000, 13700);(0.1moi/L NaOH)216, 9600 NM & epsilon; 14500,).
Last Update：2025-06-10 22:55:16
106941-25-7 - Nature
Open Data Verified Data
isopropyl alcohol, pyridine and petroleum ether mixture, cooling drop add phosphorus trichloride petroleum ether solution, after reaction, filtration, filter cake with petroleum ether wash, combined filtrate, reduced pressure concentration after distillation, triisopropyl phosphite. The ester was added dropwise to 1-chloro-2-chloromethoxyethyloxane for reaction and distilled under reduced pressure to give diisopropyl 2-chloroethoxymethylphosphonate. Adenine was suspended in dimethylformamide, potassium carbonate was added, 2 chloroethoxymethylphosphonic acid diisopropyl Ester was added dropwise to the reaction, filtered, concentrated under reduced pressure, and recrystallized with acetonitrile, 9-(2-isopropoxyphosphonomethyloxyethyl) adenine was obtained. The adenine was suspended in acetonitrile, sodium iodide and chlorotrimethylsilane were added, the reaction was refluxed, concentrated under reduced pressure, water was added, and the pH was adjusted to 7 with aqueous ammonia. The pH was adjusted to 4 with acetic acid, filtered, and recrystallized from water to give adefovir. Difovir was suspended in dimethylformamide, and triethylamine, N.N '-= cyclohexyl-4-morpholinamidine and methyl chloride tervalate were added for reaction, followed by filtration, concentration, toluene extraction, dipivoxil was evaporated to dryness.
Last Update：2025-06-10 22:55:16
106941-25-7 - Application
Open Data Verified Data
developed by Gilead Science, Inc., and approved for marketing by the US FDA on September 20, 2002. Nucleoside antiviral drugs, also belong to reverse transcriptase inhibitors. Adefovir dipivoxil is a prodrug of Adefovir dipivoxil, which is hydrolyzed to Adefovir dipivoxil after oral administration without phosphate
Has Anti Virus effect, the product can inhibit the activity of HBV-DNA of the polymerase, and can penetrate into the Virus of the DNA of hepatitis B, inhibit Virus of the replication, both lamivudine and famciclovir resistant HBV Virus strains had strong inhibitory effect.
Last Update：2025-08-19 16:24:40
Supplier List
Featured ProductsSpot supply
Product Name: Adefovir Visit Supplier Webpage Request for quotationCAS: 106941-25-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Adefovir Request for quotationCAS: 106941-25-7
Tel: 021-60556179
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Product Name: Adefovir Request for quotation
CAS: 106941-25-7
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CAS: 106941-25-7
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Spot supply
Product Name: Adefovir Request for quotationCAS: 106941-25-7
Tel: +86-13776910623
Email: r@reformchem.com
Mobile: +86-13776910623
QQ: 3785839865
Wechat: chemical6666
Spot supply
Product Name: Adefovir Request for quotationCAS: 106941-25-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Adefovir Visit Supplier Webpage Request for quotationCAS: 106941-25-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: GS-0393; PMEA Visit Supplier Webpage Request for quotationCAS: 106941-25-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Multiple SpecificationsSpot supply
Product Name: Adefovir Visit Supplier Webpage Request for quotationCAS: 106941-25-7
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: Adefovir Request for quotation
CAS: 106941-25-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 106941-25-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: Adefovir Visit Supplier Webpage Request for quotationCAS: 106941-25-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: Adefovir Visit Supplier Webpage Request for quotationCAS: 106941-25-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Adefovir Request for quotationCAS: 106941-25-7
Tel: 021-60556179
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Product Name: Adefovir Request for quotation
CAS: 106941-25-7
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CAS: 106941-25-7
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Spot supply
Product Name: Adefovir Request for quotationCAS: 106941-25-7
Tel: +86-13776910623
Email: r@reformchem.com
Mobile: +86-13776910623
QQ: 3785839865
Wechat: chemical6666
Spot supply
Product Name: Adefovir Request for quotationCAS: 106941-25-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Adefovir Visit Supplier Webpage Request for quotationCAS: 106941-25-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: GS-0393; PMEA Visit Supplier Webpage Request for quotationCAS: 106941-25-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Multiple SpecificationsSpot supply
Product Name: Adefovir Visit Supplier Webpage Request for quotationCAS: 106941-25-7
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: Adefovir Request for quotation
CAS: 106941-25-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 106941-25-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: Adefovir Visit Supplier Webpage Request for quotationCAS: 106941-25-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
106941-25-7
Bac
exo-3-Benzyl-3-azabicyclo...
OCPA
7635-29-2
Kyanacetamid
101682-68-2
100-13-0
591-21-9
5355-17-9
Bac
exo-3-Benzyl-3-azabicyclo...
OCPA
7635-29-2
Kyanacetamid
101682-68-2
100-13-0
591-21-9
5355-17-9