1034895-42-5
9-ING-41
CAS: 1034895-42-5
Molecular Formula: C22H13FN2O5
1034895-42-5 - Names and Identifiers
1034895-42-5 - Physico-chemical Properties
| Molecular Formula | C22H13FN2O5 |
| Molar Mass | 404.35 |
| Solubility | DMSO : 250 mg/mL (618.28 mM; Need ultrasonic) |
| Storage Condition | -20℃ |
| Use | 9-ING-41 is a potent glycogen synthase kinase 3 (GSK-3) inhibitor. 9-ING-41 induces prophase apoptosis and cell cycle arrest by targeting centrosome and microtubule-bound GSK-3β. 9-ING-41 has anti-tumor activity. |
| Target | GSK-3β |
| In vitro study | 9-ING-41 is a clinically relevant small-molecule GSK-3β inhibitor with a broad spectrum of preclinical antitumor activity, which can inhibit the growth of neuroblastoma cells. |
| In vivo study | 9-ING-41 has single-agent antitumor activity in the MCL mouse model. Mouse xenograft studies have shown that the combination of CPT-11 and 9-ING-41 at clinically relevant doses can produce a greater antitumor effect than either drug alone. |
1034895-42-5 - Reference
| Reference Show more | 1: Karmali R, Chukkapalli V, Gordon LI, Borgia JA, Ugolkov A, Mazar AP, Giles FJ. GSK-3β inhibitor, 9-ING-41, reduces cell viability and halts proliferation of B-cell lymphoma cell lines as a single agent and in combination with novel agents. Oncotarget. 2017 Nov 11;8(70):114924-114934. doi: 10.18632/oncotarget.22414. eCollection 2017 Dec 29. PubMed PMID: 29383130; PubMed Central PMCID: PMC5777742. 2: Ugolkov A, Qiang W, Bondarenko G, Procissi D, Gaisina I, James CD, Chandler J, Kozikowski A, Gunosewoyo H, O'Halloran T, Raizer J, Mazar AP. Combination Treatment with the GSK-3 Inhibitor 9-ING-41 and CCNU Cures Orthotopic Chemoresistant Glioblastoma in Patient-Derived Xenograft Models. Transl Oncol. 2017 Aug;10(4):669-678. doi: 10.1016/j.tranon.2017.06.003. Epub 2017 Jun 30. PubMed PMID: 28672195; PubMed Central PMCID: PMC5496477. |
1034895-42-5 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.473 ml | 12.366 ml | 24.731 ml |
| 5 mM | 0.495 ml | 2.473 ml | 4.946 ml |
| 10 mM | 0.247 ml | 1.237 ml | 2.473 ml |
| 5 mM | 0.049 ml | 0.247 ml | 0.495 ml |
Last Update：2024-01-02 23:10:35
1034895-42-5 - Reference Information
| use | 9-ING-41 is an effective inhibitor of glycogen synthase kinase 3(GSK-3) and has anti-tumor activity. 9-ING-41 induces prophase apoptosis and cell cycle arrest by targeting centrosome and binding microtubule GSK3β. |
| in vivo study | 9-ING-41 has mono-drug antitumor activity in MCL mouse models. Mouse xenograft studies have shown that a combination of clinically relevant doses of CPT-11 and 9-ING-41 produces a greater antitumor effect than either drug alone. |
| in vitro study | 9-ING-41 is a clinically relevant small molecule GSK-3β inhibitor with broad-spectrum preclinical anti-tumor activity and can inhibit the growth of neuroblastoma cells. |
| biological activity | 9-ING-41 is an effective inhibitor of glycogen synthase kinase-3 (GSK-3) and has anti-tumor activity. 9-ING-41 induces apoptosis and cell cycle arrest in the prophase of cell division by targeting centrosome and binding to microtubule GSK3β. |
| target | TargetValue GSK-3 () |
| Target | Value |
Last Update：2024-04-09 21:54:55
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View History
1034895-42-5
Iodonium, diphenyl-, nitrate
1-Z-4-piperidon
Z-D-Chg-OH
1361951-15-6
沙沙利汀杂质24
FATTYACIDSUNSATURATEDC18DIMERSNON-DISTILLED
2-环丙基乙酸乙酯
BOC-D-亮氨酸甲酯
OCT-1-EN-3-ONE
Iodonium, diphenyl-, nitrate
1-Z-4-piperidon
Z-D-Chg-OH
1361951-15-6
沙沙利汀杂质24
FATTYACIDSUNSATURATEDC18DIMERSNON-DISTILLED
2-环丙基乙酸乙酯
BOC-D-亮氨酸甲酯
OCT-1-EN-3-ONE