10-CMA
9-Oxo-10(9H)-acridineacetic acid
CAS: 38609-97-1
Molecular Formula: C15H11NO3
10-CMA - Names and Identifiers
| Name | 9-Oxo-10(9H)-acridineacetic acid |
| Synonyms | 10-CMA XBIO-101 Cridanimod Cridanimod sodium Aridone acetic acid Acridone Acetic Acid N-(Carboxymethyl)-9-acridone 10-CARBOXYMETHYL-9-ACRIDANONE 10-carboxymethyl-9-acridanone 9-Oxo-10(9H)-acridineacetic acid 10-Carboxymethylacridin-9(10H)-one (9-Oxo-10(9H)-acridinyl)acetic acid (9-oxoacridin-10(9H)-yl)acetic acid 9-Oxo-9,10-dihydro-10-acridineacetic acid |
| CAS | 38609-97-1 |
| EINECS | 634-833-1 |
| InChI | InChI=1/C15H11NO3/c17-14(18)9-16-12-7-3-1-5-10(12)15(19)11-6-2-4-8-13(11)16/h1-8H,9H2,(H,17,18) |
| InChIKey | UOMKBIIXHQIERR-UHFFFAOYSA-N |
10-CMA - Physico-chemical Properties
| Molecular Formula | C15H11NO3 |
| Molar Mass | 253.25 |
| Density | 1.362 |
| Melting Point | ~289°C (dec.) |
| Boling Point | 486.6±34.0 °C(Predicted) |
| Flash Point | 248.1°C |
| Solubility | Aqueous Base (Slightly), DMSO (Slightly) |
| Vapor Presure | 2.79E-10mmHg at 25°C |
| Appearance | Yellow to Green Crystals |
| Color | Pale Yellow to Light Yellow |
| Maximum wavelength(λmax) | ['410nm(H2O)(lit.)'] |
| BRN | 227508 |
| pKa | 3.69±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.657 |
| MDL | MFCD00157050 |
| Use | 9-oxo-10 (9H)-acridine carboxylic acid and its analogs act as interferon inducers to study their potential activity. |
10-CMA - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | AR7190000 |
10-CMA - Reference Information
| biological activity | Cridanimod is an effective progesterone receptor (PR) activator, which can significantly increase the expression of PR by inducing the expression of IFNα and IFNβ. Cridanimod is a small molecule immunomodulator and interferon inducer. |
| target | PR, IFNα, IFNβ |
| Animal Model: | Athymic mice with hec50co cells |
| Dosage: | 1, 3, 6 mg |
| Administration: | IM; twice a week |
| Result: | Had a significantly longer survival time. |
| Uses | Pre-column derivatization reagent for amino acids in HPLC fluorescence determination method |
Last Update：2024-04-10 22:29:15
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