1-N-Benzyl-3-Hydroxy-Piperidine
1-Benzyl-3-piperidinol
CAS: 14813-01-5
Molecular Formula: C12H17NO
1-N-Benzyl-3-Hydroxy-Piperidine - Names and Identifiers
| Name | 1-Benzyl-3-piperidinol |
| Synonyms | 1-Benzyl-3-piperidinol N-BENZYL-3-PIPERIDINOL 1-BENZYL-3-PIPERIDINOL N-Benzyl-3-Piperidinol 1-Benzylpiperidin-3-Ol 1-BENZYL-PIPERIDIN-3-OL 1-Benzyl-Piperidin-3-Ol N-Benzyl-3-Hydroxypiperidine N-BENZYL-3-HYDROXYPIPERIDINE 1-BENZYL-3-HYDROXYPIPERIDINE 1-Benzyl-3-Hydroxypiperidine 1-Phenylmethyl-3-Piperidinol 3-Piperidinol, 1-Phenylmethyl- 1-N-BENZYL-3-HYDROXY-PIPERIDINE 1-N-Benzyl-3-Hydroxy-Piperidine Cis-1-Benzyl-2-Methyl-3-Amino Pyrrolidine CIS-1-BENZYL-2-METHYL-3-AMINO PYRROLIDINE |
| CAS | 14813-01-5 |
| EINECS | 238-881-0 |
| InChI | InChI=1/C12H17NO/c14-12-7-4-8-13(10-12)9-11-5-2-1-3-6-11/h1-3,5-6,12,14H,4,7-10H2 |
| InChIKey | UTTCOAGPVHRUFO-UHFFFAOYSA-N |
1-N-Benzyl-3-Hydroxy-Piperidine - Physico-chemical Properties
| Molecular Formula | C12H17NO |
| Molar Mass | 191.27 |
| Density | 1,056 g/cm3 |
| Melting Point | 168-172℃ |
| Boling Point | 140-142°C 6mm |
| Flash Point | >230°F |
| Vapor Presure | 0.000631mmHg at 25°C |
| Appearance | Pale yellow to colorless transparent liquid |
| Color | Colorless to Light yellow |
| BRN | 135964 |
| pKa | 14.82±0.20(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Sensitive | Hygroscopic |
| Refractive Index | n20/D 1.549 |
1-N-Benzyl-3-Hydroxy-Piperidine - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 2 |
| HS Code | 29333990 |
1-N-Benzyl-3-Hydroxy-Piperidine - Reference Information
| introduction | 1-benzyl -3-piperidinol has a melting point of 168 to 172 degrees, a density of 1.1, and a white solid appearance under normal temperature and pressure. 1-benzyl-3-piperidinol is soluble in common organic solvents, such as dimethyl sulfoxide, N,N-dimethylformamide, dichloromethane, ethyl acetate and alcohols such as methanol and ethanol Solvents, but the solubility in water is poor. It is a common organic synthesis intermediate. |
| Uses | 1-benzyl-3-piperidinol is a common organic synthesis intermediate. First, benzyl can be hydrogenated by palladium and carbon. The group is removed and becomes 3-hydroxypiperidine. Generally speaking, this hydrogenation reaction is simple to operate, and the reaction efficiency is very high, almost no post-treatment is required, so the yield is very high. In addition, the hydroxyl group on the piperidine ring can undergo hydroxyl-related transformations, including conversion to amino groups, oxidation to ketones, and conversion to halogens. |
| synthesis method | dissolve 3-hydroxypiperidine in acetone, add a weak base as an acid binding agent, add the corresponding benzyl bromide, and stir for several hours at room temperature to obtain 1-benzyl-3-piperidinol. It is worth noting that the feeding ratio of the reaction needs to be paid special attention. The amount of benzyl bromide should not be excessive, otherwise it will generate by-products in which the amino and hydroxyl groups are protected by benzyl groups, resulting in a decrease in yield. |
| environmental hazards | 2, 4-dichloro-5-methoxypyrimidine, as an organic compound containing halogen-containing heteroaromatic ring, is more harmful to the water environment. undiluted or a large number of products should not be allowed to contact groundwater, waterways or sewage systems. |
Last Update：2024-04-09 20:49:11
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View History
1-N-Benzyl-3-Hydroxy-Piperidine
Acetic acid, decyl ester
双(环辛酸酯)铁(0)
5-Amino-1-naphthol hydrochloride
beta-D-ribopyranose
Lipoamido-PEG7-azide
4-Amino-3-fluoro phenol
4-溴苯基丙烯酸酯
2,2-Dichloroacetaldehyde
1-AMINOGUANIDINE BICARBONATE
Acetic acid, decyl ester
双(环辛酸酯)铁(0)
5-Amino-1-naphthol hydrochloride
beta-D-ribopyranose
Lipoamido-PEG7-azide
4-Amino-3-fluoro phenol
4-溴苯基丙烯酸酯
2,2-Dichloroacetaldehyde
1-AMINOGUANIDINE BICARBONATE