1-Boc-azetidine-3-ylmethanol
1-Boc-azetidine-3-ylmethanol
CAS: 142253-56-3
Molecular Formula: C9H17NO3
1-Boc-azetidine-3-ylmethanol - Names and Identifiers
1-Boc-azetidine-3-ylmethanol - Physico-chemical Properties
| Molecular Formula | C9H17NO3 |
| Molar Mass | 187.24 |
| Density | 1.115 |
| Melting Point | 55 °C |
| Boling Point | 268-273℃ |
| Flash Point | 117°(243°F) |
| Solubility | Soluble in Dimethyl sulfoxide (DMSO). |
| Appearance | White powder |
| Color | White to Almost white |
| pKa | 14.82±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | Sensitive to air |
| MDL | MFCD06656141 |
1-Boc-azetidine-3-ylmethanol - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S23 - Do not breathe vapour. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37 - Wear suitable gloves. S60 - This material and its container must be disposed of as hazardous waste. |
| TSCA | No |
| HS Code | 29339900 |
| Hazard Class | IRRITANT |
1-Boc-azetidine-3-ylmethanol - Reference Information
| use | 3-hydroxymethylazetin-1-carboxylic acid tert-butyl ester belongs to azetin-butane derivatives, azetin-butane has a certain ring tension, strong rigidity, folded molecules in conformation, and the bending degree of the bond angle relative to the plane is about 10 ° ~ 20 °. Due to the particularity of the structure, it has some chemical properties of ternary nitrogen-containing heterocycle and five-membered nitrogen-containing heterocycle, and it also shows special biological and physiological activities, and many natural products contain nitrogen heterocyclic butane and exhibit biological activity, so it has aroused widespread interest in synthetic chemistry and medicinal chemistry for decades and has been studied in a large number of years. |
| Synthesis method | Using valerolactone as the starting material, the ring is formed into methyl 2,5-dibromovalerate by bromine substitution, and then cyclized with-α-phenylethylamine to generate aza1- [( S) -1-phenylethyl]-3-methoxycarbonyl azetane, which is separated by column chromatography, after lithium aluminum hydride is reduced to alcohol, the hydrogen is removed from 1-phenylethyl and the Boc protecting group is introduced to generate 3-hydroxymethylazetin-1-carboxylic acid tert-butyl ester. The synthesis reaction formula is as follows: |
Last Update：2024-04-09 15:16:47
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View History
1-Boc-azetidine-3-ylmethanol
2,3-DIFLUOROANILINE
Glycine, N-glycyl-, methyl ester
is[omega-[(1-oxo-2-propenyl)oxy]-
2-CHLORO-5-METHOXYNITROBENZENE
(S,R)-BtbbIn-Sabox
TetramethylPPhenylenediamineDihcl
(R)-哌嗪-2-甲酸
6-Amino-2-naphthalenecarboxylic acid
2H-PYRAZOLE-3-CARBOXALDEHYDE
2,3-DIFLUOROANILINE
Glycine, N-glycyl-, methyl ester
is[omega-[(1-oxo-2-propenyl)oxy]-
2-CHLORO-5-METHOXYNITROBENZENE
(S,R)-BtbbIn-Sabox
TetramethylPPhenylenediamineDihcl
(R)-哌嗪-2-甲酸
6-Amino-2-naphthalenecarboxylic acid
2H-PYRAZOLE-3-CARBOXALDEHYDE