1-(1-Cyclohexenyl)acetylene
1-Ethynylcyclohexene
CAS: 931-49-7
Molecular Formula: C8H10
1-(1-Cyclohexenyl)acetylene - Names and Identifiers
1-(1-Cyclohexenyl)acetylene - Physico-chemical Properties
| Molecular Formula | C8H10 |
| Molar Mass | 106.17 |
| Density | 0.903 g/mL at 25 °C(lit.) |
| Boling Point | 148-151 °C(lit.) |
| Flash Point | 85 °F |
| Storage Condition | Room Temprature |
| Refractive Index | n20/D 1.496(lit.) |
1-(1-Cyclohexenyl)acetylene - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R10 - Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | UN 3295 3/PG 3 |
1-(1-Cyclohexenyl)acetylene - Upstream Downstream Industry
| Downstream Products | 1-vinylcyclohexene HEXYLCYCLOHEXANE |
1-(1-Cyclohexenyl)acetylene - Nature
| storage conditions | 2-8°C |
| maximum wavelength (& lambda;max) | 224nm(EtOH)(lit.) |
| EPA chemical information | Cyclohexene, 1-ethynyl- (931-49-7) |
Last Update：2024-04-10 22:29:15
1-(1-Cyclohexenyl)acetylene - Security information
| WGK Germany | 3 |
| HazardClass | 3.2 |
| PackingGroup | III |
Last Update：2024-04-10 22:29:15
1-(1-Cyclohexenyl)acetylene - Uses and synthesis methods
introduction
1-ethynyl-cyclohexane is an organic intermediate. It has been reported in the literature that it can be used to prepare (E)-2, 2-difluoro-1-phenyl-4-cyclohexenyl-3-en-4-iodo-1-one and 4-phenoxyquinolino N-sulfonamidine compounds.
application example
1-ethynyl-cyclohexane can be used to prepare 4-phenoxyquinolino-N-sulfonamidines having the following structure. These compounds can be used as tyrosine kinase inhibitors, especially c-Met inhibitors. c-Met is highly expressed in most solid tumors and some sarcomas and is closely related to poor prognosis, such as lung cancer, breast cancer, colon cancer, prostate cancer, liver cancer, gastric cancer and glioma. In addition, patients with high HGF/c-Met expression levels have stronger resistance to chemotherapy and radiotherapy. In addition to the abnormal expression of HGF/c-Met, c-Met can also be activated by gene mutation and gene amplification in cancer patients.
Last Update：2024-04-09 21:54:55
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View History
1-(1-Cyclohexenyl)acetylene
5-乙酰基-2,3-二氢苯并[b]呋喃
Cyclopentene-1,2-dicarboxylic anhydride
6(5H)-Phenantridinone
5-乙酰基-2,3-二氢苯并[b]呋喃
Cyclopentene-1,2-dicarboxylic anhydride
6(5H)-Phenantridinone
Downstream Products for 1-(1-Cyclohexenyl)acetylene