1,3-DIOXOLANE
1,3-Dioxolane
CAS: 646-06-0
Molecular Formula: C3H6O2
1,3-DIOXOLANE - Names and Identifiers
| Name | 1,3-Dioxolane |
| Synonyms | Dioxolan 1,3-dixolane 1,3-Dioxolan 1,3-Dioxolane 1,3-Dioxalane 1,3-DIOXOLANE dihydro-1,3-dioxole 1,3-dioxolane stab. glycolmethyleneether 1,3-dioxole,dihydro- 1.3-Dioxacyclopentane 1,3-Dioxole, dihydro- 1,3-DIOXACYCLOPENTANE Formaldehyde ethylene acetal Methyleneglycolmethyleneether Ethylene glycol methylene ether |
| CAS | 646-06-0 |
| EINECS | 211-463-5 |
| InChI | InChI=1/C3H6O2/c1-2-5-3-4-1/h1-3H2 |
| InChIKey | WNXJIVFYUVYPPR-UHFFFAOYSA-N |
1,3-DIOXOLANE - Physico-chemical Properties
| Molecular Formula | C3H6O2 |
| Molar Mass | 74.08 |
| Density | 1.06 g/mL at 25 °C (lit.) |
| Melting Point | -95 °C (lit.) |
| Boling Point | 75-76 °C/1.013 hPa |
| Flash Point | 35°F |
| Water Solubility | SOLUBLE |
| Solubility | 1000g/l soluble |
| Vapor Presure | 70 mm Hg ( 20 °C) |
| Vapor Density | 2.6 (vs air) |
| Appearance | Liquid |
| Color | White to off-white |
| Exposure Limit | ACGIH: TWA 20 ppm |
| BRN | 102453 |
| Storage Condition | Store at <= 20°C. |
| Stability | Below 4°C |
| Explosive Limit | 2.1-20.5%(V) |
| Refractive Index | n20/D 1.401(lit.) |
| Physical and Chemical Properties | Colorless transparent liquid. Freezing point -95 ℃, boiling point 78 ℃(100kPa), relative density 1.066(15/4 ℃), refractive index 1.3974, flash point 1 ℃. Miscible with water, soluble in alcohol, ether and benzene. Azeotrope with water, azeotrope 70-73 °c, 6.7% water. Can make the bromine water decolorization. |
| Use | Mainly used as solvent of oil and fat, extraction agent, electrolytic solvent of lithium battery, chlorine-based solvent stabilizer, drug intermediate, etc |
1,3-DIOXOLANE - Risk and Safety
| Hazard Symbols | F - Flammable |
| Risk Codes | 11 - Highly Flammable |
| Safety Description | 16 - Keep away from sources of ignition. |
| UN IDs | UN 1166 3/PG 2 |
| WGK Germany | 1 |
| RTECS | JH6760000 |
| TSCA | Yes |
| HS Code | 29329970 |
| Hazard Class | 3 |
| Packing Group | II |
| Toxicity | LD50 orally in Rabbit: 3000 mg/kg LD50 dermal Rabbit 9074 mg/kg |
1,3-DIOXOLANE - Nature
Open Data Verified Data
A colorless transparent liquid at room temperature. The relative density was 1. 060. Boiling Point (102kPa) 78. Freezing point -95 °c. Flash point 1 ℃. Refractive index) 4005. The heat of combustion was 1.7MJ/mol. Heat of vaporization: 481 kJ/mol. Heat of formation -341. 75kj/mol. Azeotropic with water (azeotropic mixture of water 6. 7%), the azeotropic point of 70~73 deg C. Soluble in ethanol, ether, acetone, and water can be freely miscible, and can make the bromine water decolorization.
Last Update：2025-06-10 22:55:16
1,3-DIOXOLANE - Preparation Method
Open Data Verified Data
with paraformaldehyde as raw material and ethylene glycol in the presence of concentrated sulfuric acid reaction, sodium chloride salting out, Solid alkali drying, distillation to get the finished product.
Last Update：2022-01-01 10:57:06
1,3-DIOXOLANE - Application
Open Data Verified Data
This product is the second monomer of the copolymer of formaldehyde, and it is a good solvent.
Last Update：2025-08-19 16:24:40
1,3-DIOXOLANE - Safety
Open Data Verified Data
- low toxicity. But long-term contact with the skin can cause degreasing aging. After inhalation of 80mg/L vapor, the mice were excited, anesthetized and slowed down, and finally died. The maximum allowable concentration in air is 50mg/m3. Operators should wear filter-type gas masks, closed protective glasses and protective clothing to avoid direct contact with the human body.
- the use of iron barrels, plastic barrels or glass bottles, according to the general provisions of the storage and transportation of chemicals.
Last Update：2022-01-01 10:57:07
1,3-DIOXOLANE - Reference Information
| LogP | -0.37 at 20℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | This product is the second monomer of the copolymerized paraformaldehyde, and the product is 95: copolymerization was carried out at a ratio of 5 to produce paraformaldehyde. The product is also used as a solvent, is also a silk finishing agent and sealing glue. It is mainly used as solvent and extractant of oil and fat, electrolytic solvent of lithium battery, chlorine-based solvent stabilizer, drug intermediate, etc. It is an excellent organic solvent, mainly used as oil and fat solvent, extraction agent, electrolytic solvent of lithium battery, chlorine-based solvent stabilizer low boiling point solvent. An excellent organic solvent, used as solvent and extractant of oil and fat; Electrolytic solvent of lithium battery; Chlorine-based solvent stabilizer used as solvent of low boiling point compounds, and oils, waxes, dyes and fiber derivatives extraction agent |
| production method | is obtained by reacting paraformaldehyde with ethylene glycol. Paraformaldehyde and ethylene glycol were put into a reaction kettle at a molar ratio of 1:1.25, and the reaction was carried out at 90-110 ° C. Under normal pressure using a strongly acidic ion exchange resin as a catalyst. The 70-74 ° C. Azeotrope was distilled off from the top of the distillation column, and after salting out with sodium chloride and dehydration with anhydrous calcium chloride, the azeotrope was further distilled and purified. The 71-74 ° C. Fraction was cut, and the water content was removed to 200ppm with molecular sieve to obtain a finished product. Another operation is to react paraformaldehyde with ethylene glycol in the presence of concentrated sulfuric acid, salting out with sodium chloride, drying with solid alkali, and distilling to obtain the product. Raw material consumption quota: paraformaldehyde (93-95%)750kg/t, ethylene glycol 200kg/t. |
| category | flammable liquid |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 3000 mg/kg; Oral-mouse LD50: 3200 mg/kg |
| stimulation data | Skin-rabbit 530 mg mild; Eye-rabbit 750 μg severe |
| flammability hazard characteristics | in case of open flame, high temperature, flammable oxidant; Combustion stimulus smoke |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; Stored separately from oxidants and acids |
| extinguishing agent | dry powder, dry sand, carbon dioxide, foam, 1211 extinguishing agent |
| Occupational Standard | TWA 10 mg/m3; Tel 50 mg/m3 |
| spontaneous combustion temperature | 525 ° F. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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