-5-nitropyridine-2,6-diamine

-5-nitropyridine-2,6-diamine - Names and Identifiers

Name	N6-[(4-fluorophenyl)methyl]-3-nitropyridine-2,6-diamine
Synonyms	-5-nitropyridine-2,6-diamine 2-Amino-3-nitro-6-(4-fluorobenzylamino)pyridine N2-(4-fluorobenzyl)-5-nitropyridine-2,6-diamine 2-Amino-3-nitro-6-(4'-fluorbenzylamino)-pyridine 2-AMINO-3-NITRO-6-(4‘-FLUORBENZYLAMINO)-PYRIDINE 2-Amino-6-[(4-fluorobenzyl)-amino]-3-nitropyridine N6-[(4-fluorophenyl)methyl]-3-nitropyridine-2,6-diamine 6-n-[(4-fluorophenyl)Methyl]-3-nitropyridine-2,6-diaMine 2,6-PyridinediaMine,N6-[(4-fluorophenyl)Methyl]-3-nitro- 6-[[(4-Fluorophenyl)methyl]amino]-3-nitro-2-pyridinamine
CAS	33400-49-6
EINECS	251-498-3
InChI	InChI=1/C12H11FN4O2/c13-9-3-1-8(2-4-9)7-15-11-6-5-10(17(18)19)12(14)16-11/h1-6H,7H2,(H3,14,15,16)
InChIKey	ZVCIIRBNNSUNCH-UHFFFAOYSA-N

-5-nitropyridine-2,6-diamine - Physico-chemical Properties

Molecular Formula	C12H11FN4O2
Molar Mass	262.24
Density	1.447±0.06 g/cm3(Predicted)
Melting Point	178-180°C
Boling Point	464.5±45.0 °C(Predicted)
Flash Point	234.7°C
Solubility	DMSO (Slightly), Methanol (Slightly)
Vapor Presure	8.35E-09mmHg at 25°C
Appearance	Solid
Color	Yellow
pKa	1.52±0.50(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.689

-5-nitropyridine-2,6-diamine - Risk and Safety

WGK Germany

-5-nitropyridine-2,6-diamine - Reference Information

Uses

2-amino -6-(4-fluorobenzylamine)-3-nitropyridine is a heterocyclic derivative that can be used as a pharmaceutical intermediate.

Synthesis method

The synthesis process of flupirtine intermediate 2-amino-3-nitro-6-(4-fluorobenzylamino) pyridine (ANFP) was optimized, and 2, 6-dichloro-3-nitropyridine was selected as the starting material, at 2, the intermediate 2-amino-3-nitro-6-(4-fluorobenzylamino) pyridine was obtained by selective ammoniation and p-fluorobenzylamine amination at the 6-position to obtain a suitable synthesis process to improve the intermediate 2-amino-3-nitro-6-(4-fluorobenzylamino) pyridine The synthesis yield of pyridine saves the maximum cost. The synthesis reaction formula of 2-amino-3-nitro-6-(4-fluorobenzylamino) pyridine is as follows:

Last Update：2024-04-10 22:29:15