(ethoxymethoxy)ethane
diethoxymethane
CAS: 462-95-3
Molecular Formula: C5H12O2
(ethoxymethoxy)ethane - Names and Identifiers
| Name | diethoxymethane |
| Synonyms | Ethylal diethoxymethane diethoxy-methan 3,5-dioxaheptene 1,1-Diethoxymethane (ethoxymethoxy)ethane 1-(Ethoxymethoxy)ethane formaldehyde diethyl acetal 1,1'-(methylenebis(oxy))bis-ethan 1,1'-[methylenebis(oxy)]bis-ethan 1,1'-[methylenebis(oxy)]bis-Ethane Ethane, 1,1'-[methylenebis(oxy)]bis- |
| CAS | 462-95-3 |
| EINECS | 207-330-6 |
| InChI | InChI=1/C5H12O2/c1-3-6-5-7-4-2/h3-5H2,1-2H3 |
| InChIKey | KLKFAASOGCDTDT-UHFFFAOYSA-N |
(ethoxymethoxy)ethane - Physico-chemical Properties
| Molecular Formula | C5H12O2 |
| Molar Mass | 104.15 |
| Density | 0.831 g/mL at 25 °C (lit.) |
| Melting Point | -66.5 °C |
| Boling Point | 87-88 °C (lit.) |
| Flash Point | 22°F |
| Water Solubility | 4.2 G/100 ML |
| Solubility | 91g/l |
| Vapor Presure | 60 mm Hg ( 25 °C) |
| Vapor Density | 3.6 (vs air) |
| Appearance | Liquid |
| Color | Clear colorless |
| BRN | 1697253 |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Highly flammable. Incompatible with strong oxidizing agents, strong acids. |
| Explosive Limit | 1.5%(V) |
| Refractive Index | n20/D 1.373(lit.) |
| Physical and Chemical Properties | Colorless, clear and flammable liquid. melting point -66.5 ℃ boiling point 89 ℃ relative density 0.8319 refractive index 1.3748 soluble in acetone, water and benzene, highly soluble in ethanol, ether. |
| Use | For organic synthesis, pharmaceutical industry |
(ethoxymethoxy)ethane - Risk and Safety
| Risk Codes | R11 - Highly Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S9 - Keep container in a well-ventilated place. S37/39 - Wear suitable gloves and eye/face protection S33 - Take precautionary measures against static discharges. |
| UN IDs | UN 2373 3/PG 2 |
| WGK Germany | 2 |
| RTECS | PA8500000 |
| FLUKA BRAND F CODES | 3 |
| TSCA | Yes |
| HS Code | 2911 00 00 |
| Hazard Class | 3 |
| Packing Group | II |
| Toxicity | LD50 orally in Rabbit: 3536 mg/kg LD50 dermal Rat > 16600 mg/kg |
(ethoxymethoxy)ethane - Nature
Open Data Verified Data
colorless clear flammable liquid. Boiling point 89 deg C. Melting Point -66.5 °c. Relative density (d20) 0.8319. Refractive index 3748. Soluble in acetone, water and benzene, easily soluble in ethanol, ether. The vapor forms an explosive mixture with air.
Last Update：2025-06-10 22:55:16
(ethoxymethoxy)ethane - Preparation Method
Open Data Verified Data
It can be produced by the aldol condensation reaction of formaldehyde with ethanol (used to be a by-product in the production of out-of-phase pharmaceutics).
Last Update：2022-01-01 10:16:41
(ethoxymethoxy)ethane - Application
Open Data Verified Data
can be used to produce synthetic resins, fragrances, paints, and can be used as solvents.
Last Update：2025-08-19 16:24:40
(ethoxymethoxy)ethane - Safety
Open Data Verified Data
- volatile, irritating. The minimum anesthetic concentration in mice was 42. 5mg/L. During operation, attention should be paid to on-site ventilation, and pyrotechnic is strictly prohibited. Operators should wear protective masks.
- This product is a Class I flammable liquid. Store in a cool and ventilated place, away from fire source, and store with oxidant Isolation. Packed in an iron drum. According to the provisions of flammable chemicals storage and transportation.
Last Update：2022-01-01 10:16:42
(ethoxymethoxy)ethane - Reference Information
| LogP | 0.84 |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| introduction | diethoxymethane (DEM) has only begun to be commercialized in recent years, but it has attracted the attention of researchers due to its unique properties. Its typical properties are: suitable operating temperature range; low viscosity, easy to operate and handle; DEM has low solubility in water and water in DEM ; it forms binary azeotrope with water and ethanol respectively, which is beneficial to product purification; it is not mixed with water, easy to separate from water, and has good process economy; it has good stability, it is stable under strong alkali and weak acidic conditions such as hydroxide, sodium hydride, Grignard reagent, etc., and it is not easy to form peroxides. |
| Uses | Used in organic synthesis and pharmaceutical industry Used in the synthesis of toluene formaldehyde resin, spices, and also used in the production of solvents and paints. |
| production method | production of chloramphenicol by-products. p-nitroacetophenone is dissolved in chlorobenzene, stirred at 26-28 ℃ and bromine is added dropwise to brominate to obtain p-nitro-α-brominated acetophenone. Then urotropine was added and chlorobenzene was supplemented to prepare p-nitro-α-bromoacetophenone urotropine salt solution. The salt-forming solution is added to the hydrochloric acid solution of the 27%, and after the chlorobenzene is separated, ethanol and salt are added for hydrolysis reaction. It can also be prepared by the condensation reaction of formaldehyde and ethanol. |
| category | flammable liquid |
| toxicity classification | poisoning |
| acute toxicity | oral-rabbit LD50: 2604 mg/kg |
| flammability hazard characteristics | flammability in case of open flame, high temperature and oxidant; Combustion produces stimulating smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; Store separately from oxidants and acids |
| fire extinguishing agent | dry powder, dry sand, dry stone powder, carbon dioxide, foam |
| spontaneous combustion temperature | 346 °F |
Last Update：2024-04-09 02:00:05
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