(2R)-1-Boc-2-(hydroxymethyl)piperidine
(R)-1-N-BOC-2-HYDROXYMETHYLPIPERIDINE
CAS: 134441-61-5
Molecular Formula: C11H21NO3
(2R)-1-Boc-2-(hydroxymethyl)piperidine - Names and Identifiers
(2R)-1-Boc-2-(hydroxymethyl)piperidine - Physico-chemical Properties
| Molecular Formula | C11H21NO3 |
| Molar Mass | 215.29 |
| Density | 1.059 |
| Boling Point | 308.0±15.0 °C(Predicted) |
| Flash Point | 140.1°C |
| Vapor Presure | 6.41E-05mmHg at 25°C |
| pKa | 15.08±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.479 |
(2R)-1-Boc-2-(hydroxymethyl)piperidine - Introduction
(R)-N-Boc-2-hydroxymethylpiperidine is an organic compound with the chemical formula (R)-[(tert-butoxycarbonyl)amino]methylpyridin-2-ol. It is a white to pale yellow solid.
Nature:
- (R)-N-Boc-2-hydroxymethylpiperidine is soluble in organic solvents such as ethanol and methylene chloride.
-It is a weak base, stable under neutral or acidic conditions.
-It can participate in nucleophilic reactions and metal-catalyzed reactions.
Use:
- (R)-N-Boc-2-hydroxymethylpiperidine is an important synthetic intermediate that can be used to synthesize a variety of organic compounds, such as drugs and pesticides.
-It can be used as a catalyst to participate in asymmetric synthesis reactions and produce compounds with optical activity.
Preparation Method:
(R)-N-Boc-2-hydroxymethylpiperidine can be synthesized by a two-step reaction.
In the first step, piperidine is reacted with methyl sodium bromide to obtain 2-hydroxymethylpiperidine.
In the second step, 2-hydroxymethylpiperidine is reacted with (Boc)2O to obtain (R)-N-Boc-2-hydroxymethylpiperidine.
Safety Information:
- (R)-N-Boc-2-Hydroxymethylpiperidine has limited safety information, so it is necessary to follow relevant laboratory safety procedures when using and handling.
-It may be harmful to the environment and should not be directly discharged into the natural environment.
-When storing, it should be stored in a dry, sealed container, away from heat and fire sources.
Nature:
- (R)-N-Boc-2-hydroxymethylpiperidine is soluble in organic solvents such as ethanol and methylene chloride.
-It is a weak base, stable under neutral or acidic conditions.
-It can participate in nucleophilic reactions and metal-catalyzed reactions.
Use:
- (R)-N-Boc-2-hydroxymethylpiperidine is an important synthetic intermediate that can be used to synthesize a variety of organic compounds, such as drugs and pesticides.
-It can be used as a catalyst to participate in asymmetric synthesis reactions and produce compounds with optical activity.
Preparation Method:
(R)-N-Boc-2-hydroxymethylpiperidine can be synthesized by a two-step reaction.
In the first step, piperidine is reacted with methyl sodium bromide to obtain 2-hydroxymethylpiperidine.
In the second step, 2-hydroxymethylpiperidine is reacted with (Boc)2O to obtain (R)-N-Boc-2-hydroxymethylpiperidine.
Safety Information:
- (R)-N-Boc-2-Hydroxymethylpiperidine has limited safety information, so it is necessary to follow relevant laboratory safety procedures when using and handling.
-It may be harmful to the environment and should not be directly discharged into the natural environment.
-When storing, it should be stored in a dry, sealed container, away from heat and fire sources.
Last Update：2024-04-09 20:49:11
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