(2-phenylethyl)-hydrazin
Phenelzine
CAS: 51-71-8
Molecular Formula: C8H12N2
(2-phenylethyl)-hydrazin - Names and Identifiers
(2-phenylethyl)-hydrazin - Physico-chemical Properties
| Molecular Formula | C8H12N2 |
| Molar Mass | 136.19 |
| Density | 1.0348 (rough estimate) |
| Melting Point | 25°C |
| Boling Point | bp0.1 74° |
| pKa | 8.01±0.70(Predicted) |
| Storage Condition | Room Temprature |
| Refractive Index | nD20 1.5494 |
(2-phenylethyl)-hydrazin - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Hazard Class | IRRITANT |
| Toxicity | LD50 oral in mouse: 130mg/kg |
(2-phenylethyl)-hydrazin - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| antidepressant | phenelzine is an antidepressant and manic drug that is a monoamine oxidase inhibitor, the antidepressant effect is similar to that of niamide, which can reduce the degradation of catecholamines (norepinephrine, dopamine, serotonin) in the brain, increase the content of catecholamines, and play an antidepressant role. The effect of endogenous depression is better, and the effect of exogenous and reactive depression is not good. phenelzine sulfate is effective in the treatment of major depression, dysthymic disorder, and atypical depression, and it is useful in the treatment of both panic and phobic disorders. In some patients who are difficult to treat with tricyclic drugs, especially those with atypical depression or severe anxiety, the use of phenelzine may be effective. phenelzine can improve eating habits in some bulimia patients, however, its exact effect on the disease remains to be the results of controlled clinical trials. due to its high toxicity, phenelzine has been rarely used in clinical practice. |
| adverse reactions and precautions | 1. The common adverse reactions are orthostatic hypotension and autonomic nerve dysfunction, such as dry mouth, edema, constipation, Sleep Initiation and Maintenance Disorders, Nausea, tremor, ataxia, hyperreflexia and so on. Overdose can cause syncope, hyperhidrosis, rapid pulse, superficial breathing, etc., can be intramuscular injection of chlorpromazine against. 2. Phenelzine is toxic to the liver and can cause liver damage. Liver function should be checked regularly for long-term medication. Contraindicated in patients with hepatic insufficiency. 3. Renal insufficiency, hypertension and epilepsy patients with caution. 4. Cannot be stopped suddenly, in the use of tricyclic antidepressants (such as: imipramine hydrochloride, amitriptyline hydrochloride, nortriptyline hydrochloride, maprotiline hydrochloride, protiline hydrochloride, trimethylimipramine, etc.) this product can not be used at the same time or successively, so as to avoid toxicity. 5. Phenelzine and anticholinergic drugs, antihistamines, hypoglycemic drugs, antihypertensive drugs, barbiturates and anesthetics are not combined. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:14
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