Molecular Formula | C22H29ClO6 |
Molar Mass | 424.92 |
Density | 1.321 |
Boling Point | 628.0±55.0 °C(Predicted) |
pKa | 4.76±0.10(Predicted) |
Storage Condition | 2-8℃ |
In vitro study | D-Cloprostenol and PGF2 alpha are equipotent, about 150 times more potent than dl-cloprostenol (P < 0.05) and approximately 280 times more potent than PGE1 in inhibiting [ 3 H]PGF2 alpha binding to corpus luteum cell membranes. However, d-cloprostenol and PGF2 alpha are about 10 times more potent than dl-cloprostenol and approximately 95 times more potent than PGE1 in myometrial cell membranes. |
In vivo study | D-cloprostenol (15 g per head) is the lowest dose that consistently achieves abortion; D-cloprostenol causes mild adverse effects including salivation, defecation and hyperventilation in bitches weighing less than 10 kg. Intra-vesicle administration of a single low dose of d-cloprostenol is a safe and successful technique to induce abortion in the bitch. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.353 ml | 11.767 ml | 23.534 ml |
5 mM | 0.471 ml | 2.353 ml | 4.707 ml |
10 mM | 0.235 ml | 1.177 ml | 2.353 ml |
5 mM | 0.047 ml | 0.235 ml | 0.471 ml |