脂多糖_化工百科

中文名	脂多糖
英文名	Lipopolysaccharides
别名	脂多糖
英文别名	Lipopolysaccharides LIPOPOLYSACCHARIDE FROM ESCHERICHIA COLI
溶解度	5 mg/mlWater；:可溶于水(10mg/ml)或细胞培养基(1mg/ml)，产生浑浊淡黄色溶液，溶于盐溶液经旋涡振荡并加热到70-80℃可得到一种浓度更高的LPS溶液（20mg/ml）。1.
存储条件	2-8°C
外观	冻干粉
危险品标志	Xn - 有害物品
WGK Germany	3
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脂多糖 - 介绍

脂多糖，英文名称Lipopolysaccharides，简称LPS，是革兰氏阴性细菌细胞壁中的一种特有成分，位于细胞壁的最外层并暴露于非荚膜细菌的细胞表面，有利于维持细胞外膜的完整性，保护细菌免受胆汁盐和脂类抗生素的破坏。结构上，脂多糖由类脂A、核心多糖和O-多糖侧链组成。其中类脂质A是构成细菌内毒素的主要成分，决定其毒性强弱；而O-多糖侧链在不同细菌间是高度变化的，特异性决定细菌的血清型。LPS可以引起免疫刺激的级联反应和机体的毒性病理生理活动，包括释放内毒素引起感染性休克从而导致末梢血管虚脱。临床常通过检测LPS的存在来诊断脑膜炎。正是LPS与机体免疫机能的密切关系，生命科学研究常常提取LPS进行相关的研究，如阐明LPS的结构，代谢，免疫学，生理学，毒性，生物合成途径；诱导生长促进因子如白介素的合成与分泌；诱导疾病研究的动物模型如炎症反应，急性肺损伤。将LPS分别与FITC、TRITC或2,4,6-trinitrobenzene sulfonic acid (TNBSA)反应即可得到FITC、TRITC或TNP标记的LPS，主要用于非胸腺依赖性B细胞对细菌LPS的免疫应答研究。。LPS可通过TCA、酚、酚-氯仿-石油醚等方法制备，其中最后一种方法为粗提取法。TCA和酚提取得到的LPS在结构上、电泳图谱和内毒素水平均较相似，不同之处在于含有的核酸和蛋白质残留量不同，TCA法得到的LPS含有约2%的RNA和10%的变性蛋白。酚法提取的LPS含有达60%的RNA和少于1%的蛋白。用凝胶过滤层析可除去酚提取LPS中的残留蛋白，但是仍会留下约10-20%的核酸。进一步用离子交换层析法纯化可得到＜1%蛋白和＜1%RNA的LPS。本品来源于血清型大肠杆菌O55:B5，用苯法提取而得。其内毒素水平不少于500,000 EU (endotoxin units)/mg，经分析，1ng相当于0.5EU（鲎试剂法）和10EU（显色法）。LPS O55:B5可用于刺激人腹腔巨噬细胞（1ng/ml）以及马腹腔巨噬细胞的活动（1-100ng/ml）。

最后更新：2022-10-16 17:31:03

脂多糖 - 用途与合成方法

脂多糖是一种酰胺多糖类化合物，具有多种用途和应用。脂多糖可以用于制备各种材料，如涂料、纸张、液晶屏、荧光染料、聚合物材料等，具有较好的稳定性和生物相容性。

脂多糖的合成方法有多种，常见的方法包括酰胺化反应、胺化反应和酯化反应。

酰胺化反应是将脂肪酸和胺在适当的溶剂中反应，生成脂多糖。该方法需要有机酸催化剂和适当的温度条件。

胺化反应是将脂肪酸的羧基与氨反应生成脂多糖。该反应需要碱催化剂和适当的温度和压力条件。

酯化反应是将脂肪酸酯与胺反应生成脂多糖。该方法需要酸催化剂和适当的温度条件。

这些合成方法都可以根据具体的需求进行优化和改良，以得到所需的脂多糖化合物。脂多糖的合成方法选择应根据反应物的性质、目标产物的要求和实际操作的可行性来确定。

最后更新：2024-04-10 22:29:15

北京索莱宝科技有限公司

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产品名: 脂多糖去供应商网站查看询盘
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产品名: Lipopolysaccharides 去供应商网站查看询盘
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