淡黄色膏状物。溶于水,溶于脂肪酸、油脂、矿物油和多种有机溶剂。耐酸、耐硬水、耐无机盐,低温时耐碱,遇强碱则水解。有优良的乳化性能。
精制蓖麻油与环氧乙烷在催化剂作用下缩合制得。
可作乳化剂、填充剂、增溶剂、润湿剂、消泡剂等。用于化妆品、油墨和农药作乳化剂;纺织工业中作化纤油剂、在化纤浆料中作柔软平滑剂,可消除合成浆料的泡沫;可作油田原油脱水的破乳剂;在皮革工业中作加脂剂。
无毒。
中文名 | 氢化蓖麻油聚氧乙烯醚 |
英文名 | Ethoxylated hydrogenated castor oil |
别名 | 香精增溶剂 乳化剂HEL 乙氧基化氢化蓖麻油 氢化蓖麻油聚醚40 氢化蓖麻油聚氧乙烯醚 聚氧乙烯醚40蓖麻油 聚乙二醇40氢化蓖麻油 聚氧乙烯氢化蓖麻油 RH-40 PEG-40 氢化蓖麻油 PCA 异硬脂酸酯 |
英文别名 | hco40 hco50 cremophorrh40 Emulsifier HEL |
CAS | 61788-85-0 |
EINECS | 918-326-5 |
密度 | 0.983[at 20℃] |
沸点 | 348℃[at 101 325 Pa] |
闪点 | 242℃ |
水溶性 | 500μg/L at 20℃ |
蒸汽压 | 0Pa at 25℃ |
存储条件 | Room Temprature |
外观 | 淡黄色液体至膏状物 |
物化性质 | 用于有机磷农药的乳化及制药、油墨用乳化剂,也是纤维油剂组分之一,起乳化及抗静电等作用 |
体内研究 | 20% PEG-40 hydrogenated castor oil (10 μl) is applied to the left ear of the mouse, and the right ear served as a control. The mice are observed for development of erthyma for 6 days, no signs of irritation are observed in the mice.PEG-40 hydrogenated castor oil (injection via the tail vein; 300, 900, and 2700 mg/kg; 4 weeks) is administared for short-term toxicity. At doses of 300 and 900 mg/kg PEG-40 Hydrogenated Castor Oi exhibits no systemic toxicity. However, at a dose of 2700 mg/kg, slight ataxia is observed and body weight is reduced significantly in the males and slightly in the females.A toxicity study of blank nanoemulsion using PEG-40 hydrogenated castor oil as a surfactant is applied in order to load various active compounds for oral administration.Nearly 20% of PEG-40 hydrogenated castor oil was used to emulsify the glyceryl monooleate (GMO) as an oil to the aqueous phase. In Webster mice, 5000 mg/kg blank nanoemulsion is given orally to mice once a day for 14 days, this nanoemulsion does not produce hazardous effects, and it has no effect on food intake. |
WGK Germany | 1 |
参考资料 展开查看 | 1. [IF=2.952] Yulin Liang et al."Preparation and quality evaluation of a volatile oil microemulsion from Flos magnoliae and Centipeda minima."Mol Med Rep. 2020 Dec;22(6):4531-4540 2. [IF=2.563] Wang Yunhong et al."Oil–water partition coefficient preparation and detection in the dihydroartemisinin self-emulsifying drug delivery system."BMC BIOTECHNOLOGY. 2022 Dec;22(1):1-9 |
淡黄色膏状物。溶于水,溶于脂肪酸、油脂、矿物油和多种有机溶剂。耐酸、耐硬水、耐无机盐,低温时耐碱,遇强碱则水解。有优良的乳化性能。
精制蓖麻油与环氧乙烷在催化剂作用下缩合制得。
可作乳化剂、填充剂、增溶剂、润湿剂、消泡剂等。用于化妆品、油墨和农药作乳化剂;纺织工业中作化纤油剂、在化纤浆料中作柔软平滑剂,可消除合成浆料的泡沫;可作油田原油脱水的破乳剂;在皮革工业中作加脂剂。
无毒。
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