中文名 | Β-香树脂酮醇 |
英文名 | β-Amyrenonol |
别名 | Β-香树脂酮醇 BETA-香树脂酮醇 11-氧代-Β-香树脂醇 尾-AMYRENONOL |
英文别名 | Β-AMYRENONOL β-Amyrenonol beta-AMyrenonol 11-Oxo-β-amyrin 3β-Hydroxyoleana-12-ene-11-one 3β-Hydroxy-5α-olean-12-en-11-one Olean-12-en-11-one, 3-hydroxy-, (3b)- Olean-12-en-11-one, 3-hydroxy-, (3β)- |
CAS | 38242-02-3 |
化学式 | C30H48O2 |
分子量 | 440.71 |
熔点 | 233-234℃ |
比旋光度 | +104 (CHCl3) |
存储条件 | 2-8℃ |
体外研究 | β-Amyrenonol (11-Oxo-β-amyrin) inhibits cell growth of HL60 cells with an IC 50 value of 26.3 µM. β-Amyrenonol (11-Oxo-β-amyrin) (100 μM) significantly reduces lipopolysaccharide-induced TNFα release in THP-1 cells. CYP88D6 is characterized by in vitro enzymatic activity assays and shown to catalyze the sequential two-step oxidation of β-amyrin at C-11 to produce β-Amyrenonol (11-Oxo-β-amyrin). CYP88D6 coexpressed with β-amyrin synthase in yeast also catalyzed in vivo oxidation of β-amyrin to β-Amyrenonol. |