中文名 | Arotinolol |
英文名 | Arotinolol |
别名 | 阿罗洛尔 化合物 T10371 阿罗洛尔溶液,100PPM 阿罗洛尔溶液,1000PPM 5-(2-((3-(叔丁胺基)-2-羟丙基)硫基)噻唑-4-基)噻吩-2-甲酰胺 |
英文别名 | Arotinolol AROTINOLOL Arottnolol NSC 317940 2-(3-tert-Butylamino-2-hydroxypropylthio)-4-(5-carbamoyl-2-thienyl)thiazole 5-[2-[[3-(tert-butylamino)-2-hydroxy-propyl]thio]thiazol-4-yl]thiophene-2-carboxamide 5-[2-[3-(tert-butylamino)-2-hydroxy-propyl]sulfanyl-1,3-thiazol-4-yl]thiophene-2-carboxamide 2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]- 2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-, (+-)- |
CAS | 68377-92-4 |
化学式 | C15H21N3O2S3 |
分子量 | 371.54 |
密度 | 1.35 |
熔点 | 148-149° |
沸点 | 599.8±60.0 °C(Predicted) |
溶解度 | DMSO (微溶) 、甲醇 (微溶) |
酸度系数 | 13.71±0.20(Predicted) |
存储条件 | 2-8°C(protect from light) |
外观 | 固体 |
颜色 | Off-White to Pale Yellow |
体外研究 | Arotinolol shows its selectivity of β-adrenergic receptors, the result of Arotinolol for β1 and β2 adrenoceptors in 125 I-ICYP binding to rat cerebral cortical membranes with pK i value of 9.74 and 9.26 respectively. The selectively of β1 and β2 is equal. Arotinolol shows its potency for inhibiting the binding of the same radioligand to 5HT1B-serotonergic receptor site, Arotinolol displaces 125 I-ICYP binding to 5HT1B-receptors with the pK i values of 7.97 and 8.16 resepectively for β1 and β2 adrenergic receptors. |
上游原料 | 氢氧化钠 |
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