YUM70
YUM70(N-[1,3-Benzodioxol-5-yl(5-chloro-8-hydroxy-7-quinolinyl)methyl]butanamide)
CAS: 423145-35-1
化学式: C21H19ClN2O4
| 中文名 | YUM70 |
| 英文名 | N-[1,3-Benzodioxol-5-yl(5-chloro-8-hydroxy-7-quinolinyl)methyl]butanamide |
| 别名 | 化合物YUM70 |
| 英文别名 | YUM70 N-[1,3-Benzodioxol-5-yl(5-chloro-8-hydroxy-7-quinolinyl)methyl]butanamide Butanamide, N-[1,3-benzodioxol-5-yl(5-chloro-8-hydroxy-7-quinolinyl)methyl]- |
| CAS | 423145-35-1 |
| 化学式 | C21H19ClN2O4 |
| 分子量 | 398.84 |
| 溶解度 | DMSO |
| 存储条件 | −20℃ |
| 产品用途 | YUM70 is a potent inhibitor of GRP78 (Glucose-regulated protein, 78 kDa). YUM70, inhibited pancreatic cancer cell growth in vitro and showed in vivo efficacy in a pancreatic cancer xenograft model with no toxicity to normal tissues. YUM70 directly bound GRP78 and inactivated its function, resulting in ER stress-mediated apoptosis. A YUM70 analog conjugated with BODIPY show co-localization of the compound with GRP78 in the ER. Moreover, a YUM70-PROTAC (PROteolysis TArgeting Chimera) was synthesized to force degradation of GRP78 in pancreatic cancer cells. YUM70 showed a strong synergistic cytotoxicity with topotecan and vorinostat. |
| 参考资料 展开查看 | Samanta S, Yang S, Debnath B, Xue D, Kuang Y, Ramkumar K, Lee AS, Ljungman M, Neamati N. The hydroxyquinoline analog YUM70 inhibits GRP78 to induce ER stress-mediated apoptosis in pancreatic cancer. Cancer Res. 2021 Feb 2:canres.1540.2020. doi: 10.1158/0008-5472.CAN-20-1540. Epub ahead of print. PMID: 33531374. |
YUM70 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.507 ml | 12.536 ml | 25.073 ml |
| 5 mM | 0.501 ml | 2.507 ml | 5.015 ml |
| 10 mM | 0.251 ml | 1.254 ml | 2.507 ml |
| 5 mM | 0.05 ml | 0.251 ml | 0.501 ml |
最后更新：2024-01-02 23:10:35
供应商列表
主打产品现货供应
产品名: N-[Benzo[1,3]dioxol-5-yl-(5-chloro-8-hydroxy-quinolin-7-yl)-methyl]-butyramide 去供应商网站查看 询盘CAS: 423145-35-1
产地: 上海
包装: 25mg,5mg,50mg,100mg,1ml
规格: N965004
价格: 949,275,1423,2222,1760
库存: 现货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2881510266
微信: 19863730987/17821173903
现货供应
产品名: N-(苯并[d][1,3]二氧戊环-5-基(5-氯-8-羟基喹啉-7-基)甲基)丁酰胺 询盘CAS: 423145-35-1
产地: 上海
包装: 100mg；250mg；25mg；50mg
规格: 98%
价格: 电话、微信、QQ、邮件
库存: 现货
电话: 400-968-2212
手机: 18916960931
电子邮件: 3623107365@qq.com
QQ: 3623107365
微信: 18916960931
产品描述: N-(苯并[d][1,3]二氧戊环-5-基(5-氯-8-羟基喹啉-7-基)甲基)丁酰胺,98%,Amole/阿摩尔
主打产品现货供应
产品名: N-[Benzo[1,3]dioxol-5-yl-(5-chloro-8-hydroxy-quinolin-7-yl)-methyl]-butyramide 去供应商网站查看 询盘CAS: 423145-35-1
产地: 上海
包装: 25mg,5mg,50mg,100mg,1ml
规格: N965004
价格: 949,275,1423,2222,1760
库存: 现货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2881510266
微信: 19863730987/17821173903
现货供应
产品名: N-(苯并[d][1,3]二氧戊环-5-基(5-氯-8-羟基喹啉-7-基)甲基)丁酰胺 询盘CAS: 423145-35-1
产地: 上海
包装: 100mg；250mg；25mg；50mg
规格: 98%
价格: 电话、微信、QQ、邮件
库存: 现货
电话: 400-968-2212
手机: 18916960931
电子邮件: 3623107365@qq.com
QQ: 3623107365
微信: 18916960931
产品描述: N-(苯并[d][1,3]二氧戊环-5-基(5-氯-8-羟基喹啉-7-基)甲基)丁酰胺,98%,Amole/阿摩尔
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