Tabe
盐酸哌仑西平(pirenzepine dihydrochloride)
CAS: 29868-97-1
化学式: C19H23Cl2N5O2
| 中文名 | 盐酸哌仑西平 |
| 英文名 | pirenzepine dihydrochloride |
| 别名 | 哌伦西平 盐酸哌仑西平 二盐酸哌仑西平 哌仑西平二盐酸盐 哌仑西平二盐酸一水合物 哌仑西平盐酸盐一水 EP标准品 5,11-二氢-11-[(4-甲基-1-哌嗪基)乙酰]-6H-吡啶并[2,3-b][1,4]苯并二氮卓-6-酮二盐酸盐 11-(2-(4-甲基哌嗪-1-基)乙酰基)-5,11-二氢-6H-苯并[E]吡啶并[3,2-B][1,4]二氮杂-6-酮 二盐酸盐 |
| 英文别名 | Tabe Leblon Maghen Ulcosan Renzepin Gasteril Ulcuforton Pirenzepine HCL PIRENZEPINE HCL HYDRATE pirenzepine hydrochloride pirenzepine dihydrochloride 11-[2-(4-methylpiperazin-1-yl)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one hydrate hydrochloride 11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride 5,11-Dihydro-11-((4-methylpiperazin-1-yl)acetyl)-6H-pyrido(2,3-b)-(1,4)benzodiazepin-6-one dihydrochloride 5,11-dihydro-11-[2-(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-β][1,4]benzo- diazepin-6-one Dihydrochloride |
| CAS | 29868-97-1 |
| EINECS | 249-907-5 |
| 化学式 | C19H23Cl2N5O2 |
| 分子量 | 424.32 |
| InChI | InChI=1/C19H21N5O2.ClH.H2O/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24;;/h2-8H,9-13H2,1H3,(H,21,26);1H;1H2 |
| 熔点 | 248-250°C |
| 溶解度 | H2O: 50 mg/mL |
| 存储条件 | Inert atmosphere,2-8°C |
| 敏感性 | Hygroscopic |
| 外观 | 粉末 |
| 颜色 | white |
| MDL号 | MFCD00055214 |
| 体外研究 | The antisecretory properties of pirenzepine on gastric acid and pepsin secretion may be attributed to the antagonistic activity of the drug on muscarinic M1 receptors of gastric intramural plexuses, whereas the effect on parietal muscarinic M2 receptors seems of less importance. Additional inhibitory mechanisms on gastric secretion may be represented by pirenzepine-induced increase in somatostatin release from gastrointestinal system. Significant cytoprotective properties of pirenzepinehave been observed on a variety of experimentally induced peptic ulcerations. Pirenzepine (5-500 μg/mL) inhibits agonist-(acetylcholine-, carbachol- or nicotine-) induced contractions of the toad isolated rectus abdominis muscle, and depresses electrically provoked twitches of the rat phrenic nerve-hemidiaphragm muscle preparation. |
| 体内研究 | Pirenzepine is potent in impairing learning of an avoidance; much higher doses are required to antagonize other central muscarinic effects. Pirenzepine is found to impair passive avoidance learning when given i.c.v. 20 min pre-training. The median latencies in pirenzepine-treated animals are 79.5, 11, 27 and 25.5 seconds with doses of 0.03, 0.1, 0.3 and 1 μg per mouse respectively. Acid and pepsin secretion stimulated by either bethanechol or the vagus are inhibited in a dose-responsive manner by pirenzepine. Pirenzepine (5-25 mg/kg i.v.) depresses indirect electrical stimulation-evoked twitches of the cat tibialis anterior and soleus muscle preparations. |
| WGK Germany | 2 |
| RTECS | UU7883000 |
| 上游原料 | 三乙胺 |
| 下游产品 | 哌仑西平 |
Tabe - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.357 ml | 11.784 ml | 23.567 ml |
| 5 mM | 0.471 ml | 2.357 ml | 4.713 ml |
| 10 mM | 0.236 ml | 1.178 ml | 2.357 ml |
| 5 mM | 0.047 ml | 0.236 ml | 0.471 ml |
最后更新：2024-01-02 23:10:35
供应商列表
主打产品现货供应
产品名: 11-(2-(4-甲基哌嗪-1-基)乙酰基)-5,11-二氢-6H-苯并[e]吡啶并[3,2-b][1,4]二氮杂-6-酮 二盐酸盐 去供应商网站查看 询盘CAS: 29868-97-1
产地: 上海
包装: 250mg,1g,5g,1ml
规格: P821824
价格: 108,238,1039,550
库存: 现货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2881510266
微信: 19863730987/17821173903
提供多种规格现货供应
产品名: Pirenzepine 去供应商网站查看 询盘CAS: 29868-97-1
产地: 美国
包装: 10 mM * 1 mL;100 mg;500 mg;1 g
规格: HY-17037
库存: 现货，货期：1-2天
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: 99.89%
现货供应
产品名: Pirenzepine dihydrochloride 去供应商网站查看 询盘CAS: 29868-97-1
产地: 上海
规格: 99%
价格: 25mg 50,100mg 120,500mg 400,1g 700
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: Pirenzepine dihydrochloride 99% MedMol 货号：S84820
主打产品现货供应
产品名: 11-(2-(4-甲基哌嗪-1-基)乙酰基)-5,11-二氢-6H-苯并[e]吡啶并[3,2-b][1,4]二氮杂-6-酮 二盐酸盐 去供应商网站查看 询盘CAS: 29868-97-1
产地: 上海
包装: 250mg,1g,5g,1ml
规格: P821824
价格: 108,238,1039,550
库存: 现货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2881510266
微信: 19863730987/17821173903
提供多种规格现货供应
产品名: Pirenzepine 去供应商网站查看 询盘CAS: 29868-97-1
产地: 美国
包装: 10 mM * 1 mL;100 mg;500 mg;1 g
规格: HY-17037
库存: 现货，货期：1-2天
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: 99.89%
现货供应
产品名: Pirenzepine dihydrochloride 去供应商网站查看 询盘CAS: 29868-97-1
产地: 上海
规格: 99%
价格: 25mg 50,100mg 120,500mg 400,1g 700
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: Pirenzepine dihydrochloride 99% MedMol 货号：S84820
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