N-羟基琥珀酰亚胺
N-羟基丁二酰亚胺(N-Hydroxy succinimide)
CAS: 6066-82-6
化学式: C4H5NO3
| 中文名 | N-羟基丁二酰亚胺 |
| 英文名 | N-Hydroxy succinimide |
| 别名 | 羟基丁二酰亚胺 N-羟基丁亚二酰胺 N-羟基琥珀酰亚胺 N-羟基丁二酰亚胺 N-N-羟基琥珀酰亚胺 N-羟基丁二酰亚胺(+4℃) N-羟基丁二酰亚胺(HOSu) N-羟基琥珀酰亚胺 (HOSU) N-羟基琥珀酰亚胺(N-羟基丁二酰亚胺) N-羟基丁二酰亚胺(N-羟基琥珀酰亚胺) N-羟基琥珀酰亚胺(HOSU)|N-羟基丁二酰亚胺 |
| 英文别名 | NHS HOSu HONSU NHS OR HONSU N-HYDROXYSUCCINIMDE 1-Hydroxysuccinimide N-HYDROXYSUCCINIMIDE N-Hydroxysuccinimide N-Hydroxy succinimide NHS N-HYDROXYSUCCINIMIDE, N-Hydroxysuccinimide (HOSu) 1-hydroxy-5-pyrrolidinedione 5-Pyrrolidinedione,1-hydroxy-2 N-HYDROXY-2,5-PYRROLIDINEDIONE 1-hydroxypyrrolidine-2,5-dione 1-Hydroxy-2,5-pyrrolidinedione 1-Hydroxy-2,5-pyrrolidine-dione N-HYDROXYSUCCINIMIDE POLYMER-BOUND N-Hydroxysuccinimide POLYMER-BOUND HOSu~1-Hydroxy-2,5-pyrrolidinedione |
| CAS | 6066-82-6 |
| EINECS | 228-001-3 |
| 化学式 | C4H5NO3 |
| 分子量 | 115.09 |
| InChI | InChI=1/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H2 |
| InChIKey | NQTADLQHYWFPDB-UHFFFAOYSA-N |
| 密度 | 1.4769 (rough estimate) |
| 熔点 | 95-98°C(lit.) |
| 沸点 | 215.33°C (rough estimate) |
| 闪点 | 112.5°C |
| 水溶性 | SOLUBLE |
| 蒸汽压 | 0Pa at 25℃ |
| 溶解度 | DMSO (可溶) 、甲醇 (微溶) |
| 折射率 | 1.4080 (estimate) |
| 酸度系数 | 7.81±0.20(Predicted) |
| PH值 | 5-7 (50g/l, H2O, 20℃) |
| 存储条件 | Store at +2°C to +8°C. |
| 稳定性 | 稳定。与强氧化剂、酰氯、酸酐、强碱不相容。防潮。 |
| 敏感性 | Hygroscopic |
| 外观 | 液体或固体 |
| 颜色 | Clear yellow-brown to brown |
| BRN | 113913 |
| 物化性质 | 白色结晶体。熔点99-100℃。 |
| MDL号 | MFCD00005516 |
| 危险品标志 | Xi - 刺激性物品 |
| 风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
| 安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。 |
| WGK Germany | 3 |
| TSCA | Yes |
| 海关编号 | 29251995 |
| Hazard Note | Irritant |
| 上游原料 | 丁二酸酐 盐酸羟胺 |
| 下游产品 | 咪达普利 N-丙烯酰氧基琥珀酰亚胺 阿贝卡星 胍立莫司 |
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Biosensors and Bioelectronics 102 (2018): 63-69.https://doi.org/10.1016/j.bios.2017.11.001 21. Zhao, Delu, et al. "Effect of altering photocrosslinking conditions on the physical properties of alginate gels and the survival of photoencapsulated cells." Polymer Degradation and Stability 179 (2020): 109297.https://doi.org/10.1016/j.polymdegradstab.202 22. Zhou, Mou, et al. "Development of nanosilver doped carboxymethyl chitosan-polyamideamine alginate composite dressing for wound treatment." International Journal of Biological Macromolecules 166 (2021): 1335-1351.https://doi.org/10.1016/j.ijbiomac.2020.11.0 23. Li, Xiangyu, et al. "Folate receptor-targeting mesoporous silica-coated gold nanorod nanoparticles for the synergistic photothermal therapy and chemotherapy of rheumatoid arthritis." RSC Advances 11.6 (2021): 3567-3574.https://doi.org/10.1039/D0RA08689D 24. Lin, Zefeng, et al. "Biofunctions of antimicrobial peptide-conjugated alginate/hyaluronic acid/collagen wound dressings promote wound healing of a mixed-bacteria-infected wound." International journal of biological macromolecules 140 (2019): 330-342.https: 25. Liang, Ying, et al. "A label-free immunosensor based on PHEMA/graphene oxide nanocomposite for simultaneous electrochemical determination of alpha fetoprotein." RSC advances 9.30 (2019): 17187-17193. 26. Zhang, Haichao, et al. "Deterministic Lateral Displacement-Based Separation of Magnetic Beads and Its Applications of Antibody Recognition." Sensors 20.10 (2020): 2846.https://doi.org/10.3390/s20102846 27. Chen, S., Li, Y., Wu, S. et al. A phosphorescent probe for cephalexin consisting of mesoporous thioglycolic acid-modified Mn:ZnS quantum dots coated with a molecularly imprinted polymer. Microchim Acta 187, 40 (2020). https://doi.org/10.1007/s00604-019-403 28. [IF=10.618] Xiuhua Sun et al."Creation of antifouling microarrays by photopolymerization of zwitterionic compounds for protein assay and cell patterning."Biosens Bioelectron. 2018 Apr;102:63 29. [IF=7.46] Meng-Ke Li et al."A magnetic separation fluorescent aptasensor for highly sensitive detection of bisphenol A."Sensor Actuat B-Chem. 2018 Aug;266:805 30. [IF=6.4] Yishun Yang et al."Reduction-sensitive CD44 receptor-targeted hyaluronic acid derivative micelles for doxorubicin delivery."Int J Nanomed. 2018; 13: 4361–4378 31. [IF=5.833] Li Meng-Ke et al."A fluorescent DNA based probe for Hg(II) based on thymine-Hg(II)-thymine interaction and enrichment via magnetized graphene oxide."Microchim Acta. 2018 Mar;185(3):1-7 32. [IF=5.162] Shengxue Hu et al."Preparation of biocompatible wound dressings with long-term antimicrobial activity through covalent bonding of antibiotic agents to natural polymers."Int J Biol Macromol. 2019 Feb;123:1320 33. 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[IF=11.161] Ye Lili et al."Dendrimer-modified gold nanorods as a platform for combinational gene therapy and photothermal therapy of tumors."J Exp Clin Canc Res. 2021 Dec;40(1):1-16 42. [IF=10.435] Qiang Lei et al."A novel macrophage-mediated biomimetic delivery system with NIR-triggered release for prostate cancer therapy."J Nanobiotechnol. 2019 Dec;17(1):1-15 43. [IF=9.381] Xiujing Yin et al."Metabonomics analysis of drought resistance of wheat seedlings induced by β-aminobutyric acid-modified chitooligosaccharide derivative."Carbohyd Polym. 2021 Nov;272:118437 44. [IF=7.79] Zhigang Fang et al."Sgc8 aptamer targeted glutathione-responsive nanoassemblies containing Ara-C prodrug for the treatment of acute lymphoblastic leukemia."Nanoscale. 2019 Dec;11(47):23000-23012 45. [IF=7.711] Rong Zhang et al."A Disposable Printed Liquid Gate Graphene Field Effect Transistor for a Salivary Cortisol Test."Acs Sensors. 2021;6(8):3024–3031 46. 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N-羟基琥珀酰亚胺 - 介绍
对潮湿敏感，溶于水，易溶于丙酮、醇和乙酸乙酯；微溶于氯代烃、醚、甲苯和苯。产品易结块。
最后更新：2022-10-16 17:27:00
N-羟基琥珀酰亚胺 - 简介
N-羟基丁二酰亚胺（N-Hydroxysuccinimide，简称NHS）是一种有机化合物。
性质：
外观：白色结晶粉末。
溶解性：可溶于水、醇类和醚类溶剂。
用途：
1. 常作为生物化学和有机化学中的活化试剂，可以与氨基化合物或羟基化合物生成N-烷基酰亚胺或N-烷氧基酰亚胺。
2. 在酶学研究中，可用于交联酶和载体的制备。
制法：
常见制法是通过琼脂糖合成，将琼脂糖和次氯酸钠反应得到次氯酸琼脂糖，然后将次氯酸琼脂糖与氨基丁二酸反应，得到产物。
安全信息：
1. 具有一定的刺激性，接触皮肤、眼睛或吸入可能引起不适，应注意避免直接接触。
2. 使用时应戴上适当的防护设备，如手套、护目镜和防护服。
3. 存放时应避免与有机物和可燃物接触，远离明火和高温。
4. 在使用和处理过程中，应遵守实验室的安全操作规程。
最后更新：2024-04-10 11:14:41
供应商列表
主打产品
产品名: N-羟基丁二酰亚胺(HOSU) 询盘CAS: 6066-82-6
产地: 江苏
电话: 0512-68311833
手机: 程吴昊13962195826 殷斌18306219922 陈梦琪 13771732418
电子邮件: wuhao@highfine.com
merry@highfine.com
chenmengqi@highfine.com
QQ: 4006286883
产品描述: 产品编号：A01050
外观：白色结晶粉末
标准含量：99% HPLC
主打产品现货供应
产品名: N-羟基丁二酰亚胺 去供应商网站查看 询盘CAS: 6066-82-6
产地: 中国上海
包装: 500g，500g，1kg，100g，25g，500g，100g，1kg，50g，100g，10g
价格: 面议、电联、微信、QQ
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名称：N-羟基丁二酰亚胺 ，英文名称：1-Hydroxypyrrolidine-2,5-dione，CAS：6066-82-6 ，包装：500g，500g， 更多
主打产品
产品名: N-羟基丁二酰亚胺(HOSU) 询盘CAS: 6066-82-6
产地: 江苏
电话: 0512-68311833
手机: 程吴昊13962195826 殷斌18306219922 陈梦琪 13771732418
电子邮件: wuhao@highfine.com
merry@highfine.com
chenmengqi@highfine.com
QQ: 4006286883
产品描述: 产品编号：A01050
外观：白色结晶粉末
标准含量：99% HPLC
主打产品现货供应
产品名: N-羟基丁二酰亚胺 去供应商网站查看 询盘CAS: 6066-82-6
产地: 中国上海
包装: 500g，500g，1kg，100g，25g，500g，100g，1kg，50g，100g，10g
价格: 面议、电联、微信、QQ
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名称：N-羟基丁二酰亚胺 ，英文名称：1-Hydroxypyrrolidine-2,5-dione，CAS：6066-82-6 ，包装：500g，500g， 更多
N-羟基琥珀酰亚胺的上游原料
N-羟基琥珀酰亚胺的下游产品
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