84687-45-6_化工百科

中文名	黄芪皂苷VI
英文名	Astragaloside VI
别名	黄芪甲苷VI 黄芪皂苷VI 化合物 T13559 黄芪皂苷VI 黄芪皂苷X2
英文别名	Astragaloside VI Astragaloside VI β-D-Glucopyranoside, (3β,6α,16β,20R,24S)-20,24-epoxy-3-[(2-O-β-D-glucopyranosyl-β-D-xylopyranosyl)oxy]-16,25-dihydroxy-9,19-cyclolanostan-6-yl (3beta,6alpha,16beta,20R,24S)-20,24-Epoxy-3-[(2-O-beta-D-glucopyranosyl-beta-D-xylopyranosyl)oxy]-16,25-dihydroxy-9,19-cyclolanostan-6-yl beta-D-glucopyranoside
CAS	84687-45-6
化学式	C47H78O19
分子量	947.11
溶解度	10毫米DMSO
存储条件	2-8℃
MDL号	MFCD17214426
体外研究	Pretreatment with Astragaloside VI (AS-VI) at 1 μM increases EGFR activation in HaCaT cells. Astragaloside VI, a major intestinal metabolite of astragalosides, exerts the strongest EGFR activation. In HaCaT cells, the positive control, EGF expectedly results in 1.5±0.03-fold increase in cell proliferation, compared to the control. Astragaloside VI at the indicated concentrations also significantly promots cell proliferation in both HaCaT and HDF cells. Astragaloside VI promotes neural stem cell proliferation and enhances neurological function recovery in transient cerebral ischemic injury via activating EGFR/MAPK signaling cascades.
体内研究	Astragaloside VI improves wound healing, compared to the control. In the simple noninfected wound model, wound healing in mice is accelerated by Astragaloside VI, where in the time required for wound closure is shortened by approximately 2-4 days, compared to that in the control group. Topical treatment with Astragaloside VI reduces the volume of pus produced, compared to the control group. Astragaloside VI treated wounds show an accelerated rate of healing, compared to the control and vaseline groups. By day 22, the Astragaloside VI -treated wounds fully close, whereas the blank and vaseline-treated wounds do not fully close until day 26. Angiogenesis is a crucial step in the formation of granulation tissue and wound healing. Astragaloside VI increases blood vessel formation in both the non-infected and infected wound models. Astragaloside VI could effectively activate EGFR/MAPK signaling cascades, promote NSCs proliferation and neurogenesis in transient cerebral ischemic brains, and improve the repair of neurological functions in post-ischemic stroke rats.
参考资料展开查看	1. 李洋洋,张苡铭,魏孔熙,周婷,何进鹏,丁楠,周谷城,史桐凡,柯宜诚,牛帆,刘永琦,张利英.黄芪不同有效成分对电离辐射致BMSCs DNA损伤防护作用的比较研究[J].中国药房,2020,31(24):2987-2992. 2. Yuping Zhang, Shuyun Shi, Junfang Guo, Qingping You, Deshan Feng, On-line surface plasmon resonance-high performance liquid chromatography–tandem mass spectrometry for analysis of human serum albumin binders from Radix Astragali, Journal of Chromatography

84687-45-6 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	1.056 ml	5.279 ml	10.558 ml
5 mM	0.211 ml	1.056 ml	2.112 ml
10 mM	0.106 ml	0.528 ml	1.056 ml
5 mM	0.021 ml	0.106 ml	0.211 ml

最后更新：2024-01-02 23:10:35

北京索莱宝科技有限公司

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产品名: Astragaloside VI 去供应商网站查看询盘
CAS: 84687-45-6
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上海阿摩尔生物科技有限公司

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产品名: Astragaloside VI 询盘
CAS: 84687-45-6
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上海麦克林生化科技股份有限公司

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产品名: 黄芪皂苷VI 去供应商网站查看询盘
CAS: 84687-45-6
产地: 上海
包装: 5mg
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上海吉至生化科技有限公司

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产品名: Astragaloside VI 去供应商网站查看询盘
CAS: 84687-45-6
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产品描述: 中文名称：Astragaloside VI ，英文名称：Astragaloside VI，CAS：84687-45-6 ，包装：5mg ，价格：面议、电联、微信更多

MedChemExpress

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产品名: Astragaloside VI 去供应商网站查看询盘
CAS: 84687-45-6
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