82854-37-3
松果菊苷(echinacoside)
CAS: 82854-37-3
化学式: C35H46O20
| 中文名 | 松果菊苷 |
| 英文名 | echinacoside |
| 别名 | 海胆苷 松果菊 松果菊苷 管花肉苁蓉 松果菊苷(分析标准品) 紫锥菊苷,海胆苷,松果菊甙 ECHINACOSIDE 松果菊苷 松果菊苷(海胆苷,紫锥花苷,松果菊甙) |
| 英文别名 | beta-d-e ECHINACOSIDE echinacoside Cistanche tubulosa ECHINACOSIDE(AMERICAN HERBAL PHARMACOPOEIA) 6)]-4-O-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]- 6)]-4-O-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]- 6)]-4-O-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]-beta-D-glucopyranoside 6)]-4-O-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoyl]-beta-D-glucopyranoside 2-(3,4-dihydroxyphenyl)ethylo-6-deoxy-alpha-l-mannopyranosyl-glucopyranosid (1-3)-o-(beta-d-glucopyranosyl-(1-6))-,4-(3-(3,4-dihydroxyphenyl)-2-propenoat 6)]-4-O-[(2E)-3-(3,4-dihydroxyphényl)-2-propènan-1-oyl]-bêta-D-glucopyranoside de 2-(3,4-dihydroxyphényl)éthyle 2-(3,4-dihydroxyphenyl)ethyl 6-deoxy-alpha-L-mannopyranosyl-(1-3)-[beta-D-glucopyranosyl-(1-6)]-4-O-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]-beta-D-glucopyranoside (2R,3R,4R,5R,6R)-6-[2-(3,4-Dihydroxyphenyl)ethoxy]-5-hydroxy-2-({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}methyl)-4-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-3-yl-(2E)-3-(3,4-dihydroxyphenyl)acrylat (2R,3R,4R,5R,6R)-6-[2-(3,4-Dihydroxyphenyl)ethoxy]-5-hydroxy-2-({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}methyl)-4-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-3-yl (2E)-3-(3,4-dihydroxyphenyl)acrylate (2E)-3-(3,4-Dihydroxyphényl)acrylate de (2R,3R,4R,5R,6R)-6-[2-(3,4-dihydroxyphényl)éthoxy]-5-hydroxy-2-({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran-2-yl]oxy}méthyl)-4-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-méthyltétrahydro-2H-pyran-2-yl]oxy}tétrahydro-2H-pyran-3-yle |
| CAS | 82854-37-3 |
| 化学式 | C35H46O20 |
| 分子量 | 786.73 |
| InChI | InChI=1/C35H46O20/c1-14-24(42)26(44)29(47)35(51-14)55-32-30(48)34(49-9-8-16-3-6-18(38)20(40)11-16)53-22(13-50-33-28(46)27(45)25(43)21(12-36)52-33)31(32)54-23(41)7-4-15-2-5-17(37)19(39)10-15/h2-7,10-11,14,21-22,24-40,42-48H,8-9,12-13H2,1H3/b7-4+/t14-,21+,22+,24-,25+,26+,27-,28+,29+,30+,31+,32+,33+,34+,35-/m0/s1 |
| InChIKey | FSBUXLDOLNLABB-ISAKITKMSA-N |
| 密度 | 1.66±0.1 g/cm3(Predicted) |
| 熔点 | 220°C |
| 沸点 | 1062.7±65.0 °C(Predicted) |
| 比旋光度 | -56.5 (H2O). -74 (MeOH) |
| 闪点 | 327.8°C |
| 蒸汽压 | 0mmHg at 25°C |
| 溶解度 | DMSO : ≥ 100 mg/mL (127.11 mM) |
| 折射率 | 1.698 |
| 酸度系数 | 8.43±0.20(Predicted) |
| 存储条件 | Inert atmosphere,2-8°C |
| 敏感性 | Easily absorbing moisture |
| 外观 | 棕黄色结晶粉末 |
| BRN | 4778612 |
| 物化性质 | 来源于管花肉苁蓉。 |
| MDL号 | MFCD00075695 |
| 安全术语 | 24/25 - 避免与皮肤和眼睛接触。 |
| WGK Germany | 3 |
| RTECS | LZ5786500 |
| 海关编号 | 29389090 |
| 参考资料 展开查看 | 1. 苏珊珊 陈文 方贺 等. Box-Behnken效应面法优化松果菊苷PLGA纳米粒处方工艺[J]. 中国新药杂志 2016 025(009):1069-1074. 2. 蔡华, 张领, 李满生,等. 松果菊苷通过上调miR-34a减轻心肌细胞缺血再灌注损伤[J]. 中国循证心血管医学杂志, 2018, v.10(06):104-107+110. 3. 付志飞, 杨丽, 尚非,等. 肉苁蓉提取物对快速老化模型小鼠SAMP8行为学及肠道菌群的影响[J]. 世界科学技术-中医药现代化, 2019, 021(006):1103-1109. 4. 丁艳霞,王晓琴,张英.基于高效液相色谱的肉苁蓉属药材6个主要苯乙醇苷类成分的含量测定[J].时珍国医国药,2020,31(04):813-816. 5. 姜秋, 蒋海强, 李慧芬,等. 女贞子酒蒸过程中5种苯乙醇类成分的变化规律[J]. 中国实验方剂学杂志, 2014, 20(16):60-63. 6. 范兴, 杨成梓, 包侠萍,等. 芪骨胶囊HPLC指纹图谱研究[J]. 中草药, 2014, 045(009):1257-1261. 7. 杨成梓 范兴 包侠萍 等. HPLC同时测定芪骨胶囊中5种成分的含量[J]. 中国实验方剂学杂志 2015 021(016):60-63. 8. Shuo Li, Sheng Lei, Qian Yu, Lina Zou, Baoxian Ye,A novel electrochemical sensor for detecting hyperin with a nanocomposite of ZrO2-SDS-SWCNTs as decoration,Talanta,Volume 185,2018,Pages 453-460,ISSN 0039-9140,https://doi.org/10.1016/j.talanta.2018. 9. Shuo Li, Yinghao Duan, Sheng Lei, Jiantong Qiao, Gaiping Li, Baoxian Ye,A new electrochemical sensing strategy for echinacoside based on an original nanocomposite,Sensors and Actuators B: Chemical,Volume 274,2018,Pages 218-227,ISSN 0925-4005,https:/ 10. [IF=6.057] Shuo Li et al."A novel electrochemical sensor for detecting hyperin with a nanocomposite of ZrO2-SDS-SWCNTs as decoration."Talanta. 2018 Aug;185:453 11. [IF=4.556] Maiquan Li et al."Neuroprotective Effects of Four Phenylethanoid Glycosides on H2O2-Induced Apoptosis on PC12 Cells via the Nrf2/ARE Pathway."Int J Mol Sci. 2018 Apr;19(4):1135 12. [IF=4.411] Fangxue Xu et al."Optimization of Fermentation Condition for Echinacoside Yield Improvement with Penicillium sp. H1, an Endophytic Fungus Isolated from Ligustrum lucidum Ait Using Response Surface Methodology."Molecules. 2018 Oct;23(10):2586 13. [IF=4.411] Li Jia et al."Systematic Profiling of the Multicomponents and Authentication of Erzhi Pill by UHPLC/Q-Orbitrap-MS Oriented Rapid Polarity-Switching Data-Dependent Acquisition and Selective Monitoring of the Chemical Markers Deduced from Fingerprint Analys 14. [IF=4.183] Liwei Dong et al."Echinacoside Induces Apoptosis in Human SW480 Colorectal Cancer Cells by Induction of Oxidative DNA Damages."Int J Mol Sci. 2015 Jul;16(7):14655-14668 15. [IF=3.046] Liwei Dong et al."Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1."Oncotargets Ther. 2015; 8: 3649–3664 16. [IF=2.629] Zhang Ying et al."The Difference of Chemical Components and Biological Activities of the Raw Products slices and the Wine Steam-Processed Product from Cistanche deserticola."Evid-Based Compl Alt. 2019;2019:2167947 17. [IF=2.043] Wang Xue et al."The longevity effect of echinacoside in Caenorhabditis elegans mediated through daf-16."Biosci Biotech Bioch. 2015 Oct;79(10):1676-1683 18. [IF=9.229] Linlin Deng et al."Highly Crystalline Covalent Organic Frameworks Act as a Dual-Functional Fluorescent-Sensing Platform for Myricetin and Water, and Adsorbents for Myricetin."Acs Appl Mater Inter. 2021;13(28):33449–33463 19. [IF=6.986] Qingqing Song et al."Retention Time and Optimal Collision Energy Advance Structural Annotation Relied on LC–MS/MS: An Application in Metabolite Identification of an Antidementia Agent Namely Echinacoside."Anal Chem. 2019;91(23):15040–15048 20. [IF=6.558] Qingqing Song et al."Binary code, a flexible tool for diagnostic metabolite sequencing of medicinal plants."Anal Chim Acta. 2019 Dec;1088:89 21. [IF=6.023] Maiquan Li et al."Discovery of Keap1−Nrf2 small−molecule inhibitors from phytochemicals based on molecular docking."Food Chem Toxicol. 2019 Nov;133:110758 22. [IF=4.142] Lei Huibo et al."Comprehensive profiling of the chemical components and potential markers in raw and processed Cistanche tubulosa by combining ultra-high-performance liquid chromatography coupled with tandem mass spectrometry and MS/MS-based molecular ne 23. [IF=4.142] Wang Chenxi et al."Systematic quality evaluation of Peiyuan Tongnao capsule by offline two-dimensional liquid chromatography/quadrupole-Orbitrap mass spectrometry and adjusted parallel reaction monitoring of quality markers."Anal Bioanal Chem. 2019 Nov;4 24. [IF=3.69] Qixin Wang et al."Phenylethanol glycosides from Cistanche tubulosa improved reproductive dysfunction by regulating testicular steroids through CYP450-3β-HSD pathway."J Ethnopharmacol. 2020 Apr;251:112500 25. [IF=3.279] Pengfei Yuan et al."Cistanche tubulosa Phenylethanoid Glycosides Induce Apoptosis of Hepatocellular Carcinoma Cells by Mitochondria-Dependent and MAPK Pathways and Enhance Antitumor Effect through Combination with Cisplatin:."Integr Cancer Ther. 2021;(): 26. [IF=2.091] Zhenhong Liu et al."GAPT regulates cholinergic dysfunction and oxidative stress in the brains of learning and memory impairment mice induced by scopolamine."Brain Behav. 2020 May;10(5):e01602 27. [IF=1.902] Chenxi Wang et al."Multiple component-pharmacokinetic studies on 10 bioactive constituents of Peiyuan Tongnao capsule using parallel reaction monitoring mode."Biomed Chromatogr. 2021 Oct;35(10):e5153 28. [IF=4.508] Chunying Li et al."A novel approach for echinacoside and acteoside extraction from Cistanche deserticola Y. C. Ma using an aqueous system containing ionic liquid surfactants."Sustain Chem Pharm. 2022 May;26:100644 |
82854-37-3 - 简介
松果菊苷（也称为甜叶菊苷）是一种天然甜味剂，化学名为苦苷。它可从松果菊（Stevia rebaudiana）的叶子中提取获得。
松果菊苷具有甜味，并且甜度较高，通常比蔗糖高200-400倍，但热量极低甚至可以忽略不计。松果菊苷稳定性较好，在高温下也不易分解。
制取松果菊苷的方法主要有水浸提、醇浸提、微生物发酵等。其中，水浸提是最常用的方法。首先将松果菊的叶子用水浸泡，然后过滤得到浸提液。接下来，经过浓缩、脱色等步骤，最终得到含有高纯度的松果菊苷的提取物。
多项研究表明，它不会引起对人体健康有害的副作用。正常的摄入量不会对血糖和胰岛素产生明显影响，适用于糖尿病患者和减肥者。个别人可能对松果菊苷过敏，在使用前应谨慎，并遵循安全摄入量。
松果菊苷具有甜味，并且甜度较高，通常比蔗糖高200-400倍，但热量极低甚至可以忽略不计。松果菊苷稳定性较好，在高温下也不易分解。
制取松果菊苷的方法主要有水浸提、醇浸提、微生物发酵等。其中，水浸提是最常用的方法。首先将松果菊的叶子用水浸泡，然后过滤得到浸提液。接下来，经过浓缩、脱色等步骤，最终得到含有高纯度的松果菊苷的提取物。
多项研究表明，它不会引起对人体健康有害的副作用。正常的摄入量不会对血糖和胰岛素产生明显影响，适用于糖尿病患者和减肥者。个别人可能对松果菊苷过敏，在使用前应谨慎，并遵循安全摄入量。
最后更新：2024-04-09 21:31:57
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产品名: 松果菊苷(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IE00101
产地: 北京
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产品名: Echinacoside 去供应商网站查看 询盘CAS: 82854-37-3
产地: 美国
包装: 5 mg;10 mg;25 mg;50 mg;100 mg
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提供多种规格现货供应
产品名: 松果菊苷(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IE00101
产地: 北京
包装: 1ml/瓶
规格: IE00101-1ml
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 18101056239(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 18101056239
产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
提供多种规格现货供应
产品名: Echinacoside 去供应商网站查看 询盘CAS: 82854-37-3
产地: 美国
包装: 5 mg;10 mg;25 mg;50 mg;100 mg
规格: HY-N0020R
库存: 询盘
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: ≥98%
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