78123-71-4
(D-ALA2,N-ME-PHE4,GLYCINOL5)-ENKEPHALIN(DAGO)
CAS: 78123-71-4
化学式: C26H35N5O6
| 中文名 | (D-ALA2,N-ME-PHE4,GLYCINOL5)-ENKEPHALIN |
| 英文名 | DAGO |
| 别名 | 化合物DAMGO L-酪氨酰-D-丙氨酰甘氨酰-N-(2-羟基乙基)-NALPHA-甲基-L-苯丙氨酰胺 |
| 英文别名 | DAGO DAMGO Tyr-D-Ala-Gly-MePhe-Gly-ol TYR-D-ALA-GLY-N-ME-PHE-GLY-OL Tyr-D-Ala-Gly-MePhe-NH-(CH2)2OH TYR-D-ALA-GLY-N-METHYL-PHE-GLY-OL (D-ALA2,N-ME-PHE4,GLYCINOL5)-ENKEPHALIN Tyr-D-Ala-Gly-N-methylphenylalanine-glycinol |
| CAS | 78123-71-4 |
| 化学式 | C26H35N5O6 |
| 分子量 | 513.59 |
| 密度 | 1.271±0.06 g/cm3(Predicted) |
| 沸点 | 922.7±65.0 °C(Predicted) |
| 酸度系数 | 9.97±0.15(Predicted) |
| 存储条件 | -15°C |
| 体外研究 | DAMGO, a μ-opioid receptor selective agonist, distinguishes between μ- and δ-opioid receptors around their first extracellular loops. In native μ-OPR, the K d value for DAMGO is 3.46± 0.84 nM (n=3). The chimeric receptor MMDD, in which the carboxy-terminal half of μ-OPR is replaced with the corresponding region of δ-OPR, exhibits an equivalent affinity (K d =2.13±0.40 nM; n=3) to DAMGO compared with the native μ-OPR. DAMGO is a selective μ-opioid peptide. DAMGO abolishes the neuroprotective effect of CXCL12 in N-methyl-d-aspartate (NMDA) neurotoxicity studies. Regulation of neuronal response to CXCL12 is essential for shaping of developing and mature central nervous system (CNS). To establish whether DAMGO alter the effect of CXCL12 on neuronal survival, the ability of CXCL12 to protect neurons from N-methyl-d-aspartate (NMDA)-induced death is examined in the presence and absence of DAMGO. Cortical cultures are treated with DAMGO (1 and 10 μM). Neurons are subsequently exposed to NMDA (20 min) and/or CXCL12 (added 10 min before NMDA) in the absence of glia and then returned to the original culture dishes with the glial feeder layer. Neuronal death is evaluated after 24 h. DAMGO inhibits neuronal survival promoted by CXCL12. |
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产品名: (D-ALA2,N-ME-PHE4,GLYCINOL5)-ENKEPHALIN 去供应商网站查看 询盘CAS: 78123-71-4
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包装: 10 mg
价格: $198
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产品描述: DAMGO is a highly selective peptide agonist of the μ opioid receptor.
产品目录: 点此进入
产品名: (D-ALA2,N-ME-PHE4,GLYCINOL5)-ENKEPHALIN 去供应商网站查看 询盘
CAS: 78123-71-4
产地: 上海
价格: 5mg 3570,10mg 5390
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产品描述: (D-ALA2,N-ME-PHE4,GLYCINOL5)-ENKEPHALIN 源叶 货号：T53688
CAS: 78123-71-4
产地: 上海
价格: 5mg 3570,10mg 5390
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: (D-ALA2,N-ME-PHE4,GLYCINOL5)-ENKEPHALIN 源叶 货号：T53688
现货供应
产品名: (D-ALA2,N-ME-PHE4,GLYCINOL5)-ENKEPHALIN 去供应商网站查看 询盘CAS: 78123-71-4
产地: 其他
包装: 10 mg
价格: $198
库存: In stock
电话: +16314854226
手机: +16314854226
电子邮件: info@bocsci.com
产品描述: DAMGO is a highly selective peptide agonist of the μ opioid receptor.
产品目录: 点此进入
产品名: (D-ALA2,N-ME-PHE4,GLYCINOL5)-ENKEPHALIN 去供应商网站查看 询盘
CAS: 78123-71-4
产地: 上海
价格: 5mg 3570,10mg 5390
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: (D-ALA2,N-ME-PHE4,GLYCINOL5)-ENKEPHALIN 源叶 货号：T53688
CAS: 78123-71-4
产地: 上海
价格: 5mg 3570,10mg 5390
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: (D-ALA2,N-ME-PHE4,GLYCINOL5)-ENKEPHALIN 源叶 货号：T53688
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