氨基酸类药。作为氨基酸输液及综合氨基酸制剂。用于幼儿特发性高血糖的诊断和治疗。并适用于糖代谢失调、伴有胆汁分泌减少的肝病、贫血、中毒、肌萎缩症、脊髓灰质炎后遗症、神经炎及精神病。用于口服,每次20~30mL(3%),一日3次。用于静注每次10~20mL (3%)。
中文名 | L-亮氨酸 |
英文名 | L-Leucine |
别名 | 亮氨酸 L-亮氨酸 L-白氨酸 氨基异己酸 L-闪白氨基酸 A一氨基异己酸 亮氨酸 (LEU) 亮氨酸溶液 (LEU) 2-氨基-4-甲基戊酸 L-2-氨基-4-甲基戊酸 (S)-2-氨基-4-甲基戊酸 亮氨酸 (LEU)溶液,100PPM L-白氨酸,L-闪白氨基酸,氨基异己酸 |
英文别名 | L-Leu Leucine H-Leu-OH L-Leucine 1-Leucine L(+)LEUCINE 4-methyl-norvalin 4-methyl-l-norvalin 2-amino-4-methyl-valericaci 2-amino-4-methylpentanoicacid 2-Amino-4-methylpentanoic acid (s)-2-amino-4-methylvalericacid (S)-2-Amino-4-methylpentanoic acid alpha-Amino-gamma-methylvaleric acid |
CAS | 61-90-5 200936-87-4 |
EINECS | 200-522-0 |
化学式 | C6H13NO2 |
分子量 | 131.17 |
InChI | InChI=1/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 |
密度 | 1,293 g/cm3 |
熔点 | >300 °C (lit.) |
沸点 | 122-134 °C(Press: 2-3 Torr) |
比旋光度 | 15.4 º (c=4, 6N HCl) |
闪点 | 145-148°C |
水溶性 | 22.4 g/L (20 C) |
蒸汽压 | <1 hPa (20 °C) |
JECFA Number | 1423 |
溶解度 | 1 M HCl: 50 mg/mL |
折射率 | 1.4630 (estimate) |
酸度系数 | 2.328(at 25℃) |
PH值 | 5.5-6.5 (20g/l, H2O, 20℃) |
存储条件 | 2-8°C |
稳定性 | 稳定性水分和光敏感。与强氧化剂不相容。 |
外观 | 粉末 |
颜色 | White to Off-white |
最大波长(λmax) | ['λ: 260 nm Amax: 0.05', , 'λ: 280 nm Amax: 0.05'] |
Merck | 14,5451 |
BRN | 1721722 |
物化性质 | 白色有光泽六面体晶体或白色结晶性粉末。略有苦味(DL-亮氨酸呈甜味)。于145~148℃升华。熔点293~295℃(分解)。在烃类存在下,在无机酸水溶液中性能稳定。每g溶于约40ml水和约100ml醋酸。微溶于乙醇(0.07%),溶于稀盐酸和碱性氢氧化物和碳酸盐溶液。不溶于乙醚。属必需氨基酸,成人男子需要量2.2g/d(151本)。为婴儿正常生长及成人维持正常氮平衡所必需。天然品存在于脾脏、心脏等中,并以蛋白质形式存在于各种动植物组织中,腐败分解后可游离而出。 |
MDL号 | MFCD00002617 |
安全术语 | 24/25 - 避免与皮肤和眼睛接触。 |
WGK Germany | 3 |
RTECS | OH2850000 |
TSCA | Yes |
海关编号 | 29224995 |
上游原料 | 碳 硫酸 碳酸氢铵 盐酸 液氨 |
下游产品 | L-苯丙氨酸 鲎试剂三肽 |
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氨基酸类药。作为氨基酸输液及综合氨基酸制剂。用于幼儿特发性高血糖的诊断和治疗。并适用于糖代谢失调、伴有胆汁分泌减少的肝病、贫血、中毒、肌萎缩症、脊髓灰质炎后遗症、神经炎及精神病。用于口服,每次20~30mL(3%),一日3次。用于静注每次10~20mL (3%)。
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