中文名 | 戊酸双氟可龙 |
英文名 | Diflucortolone valerate |
别名 | 戊酸二氟米松 戊酸双氟可龙 二氟可龙戊酸酯 双氟可龙无酸酯 双氟可龙戊酸酯 戊酸双氟可龙 标准品 双氟可龙戊酸酯 59198-70-8 |
英文别名 | Afusona Nerisone Nerisona Neriforte 59198-70-8 Nerisone Forte Youtolon[Tatsumi] DIFLUCORTOLONE VALERATE Diflucortolone valerate Diflucortolone 21-valerate Diflucortolone valerate (JAN) 6a,9-difluoro-11b,21-dihydroxy-16a-methylpregna-1,4-diene-3,20-dione 21-valerate (6alpha,11beta,16alpha)-6,9-Difluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl valerate Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11-hydroxy-16-methyl-21-[(1-oxopentyl)oxy]-, (6α,11β,16α)- (6alpha,11beta,16alpha)-6,9-difluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl pentanoate pentanoic acid, (6alpha,11beta,16alpha)-6,9-difluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl ester |
CAS | 59198-70-8 |
EINECS | 261-655-8 |
化学式 | C27H36F2O5 |
分子量 | 478.57 |
InChI | InChI=1/C27H36F2O5/c1-5-6-7-23(33)34-14-21(31)24-15(2)10-17-18-12-20(28)19-11-16(30)8-9-26(19,4)27(18,29)22(32)13-25(17,24)3/h8-9,11,15,17-18,20,22,24,32H,5-7,10,12-14H2,1-4H3/t15-,17+,18+,20+,22+,24-,25+,26+,27+/m1/s1 |
密度 | 1.1227 (estimate) |
熔点 | 220°C |
沸点 | 578.5±50.0 °C(Predicted) |
比旋光度 | D22 +100.8° (dioxane) |
闪点 | 303.7°C |
蒸汽压 | 8.58E-16mmHg at 25°C |
溶解度 | 氯仿 (微溶) 、二恶烷 (微溶) 、甲醇 (微溶) |
折射率 | 1.538 |
酸度系数 | 12.89±0.70(Predicted) |
存储条件 | -20°C Freezer, Under inert atmosphere |
外观 | 固体 |
颜色 | White to Off-White |
体外研究 | Diflucortolone valerate is a potent corticosteroid esterified with valeric acid. Diflucortolone valerate helps reduce swelling, itching, and redness. |
体内研究 | DL 50 values are virtually non-toxic after single oral administration (mouse greater than 4 g/kg, rat ca. 3.1 g/kg, dog greater than 1 g/kg). Given s.c. (LD 50 mouse ca. 180 mg/kg, rat ca. 13 mg/kg) and i.p. (LD 50 mouse ca. 450 mg/kg, rat ca. 98 mg/kg) it is highly active and therefore produces also toxic effects. |
上游原料 | 醋酸曲安奈德 |
参考资料 展开查看 | 1: Billich A, Aschauer H, Aszódi A, Stuetz A. Percutaneous absorption of drugs used in atopic eczema: pimecrolimus permeates less through skin than corticosteroids and tacrolimus. Int J Pharm. 2004 Jan 9;269(1):29-35. doi: 10.1016/j.ijpharm.2003.07.013. PMID: 14698574. 2: Henz BM, Jablonska S, van de Kerkhof PC, Stingl G, Blaszczyk M, Vandervalk PG, Veenhuizen R, Muggli R, Raederstorff D. Double-blind, multicentre analysis of the efficacy of borage oil in patients with atopic eczema. Br J Dermatol. 1999 Apr;140(4):685-8. doi: 10.1046/j.1365-2133.1999.02771.x. PMID: 10233322. 3: Täuber U, Weiss C, Matthes H. Does salicylic acid increase the percutaneous absorption of diflucortolone-21-valerate? Skin Pharmacol. 1993;6(4):276-81. doi: 10.1159/000211150. PMID: 8198813. 4: Ikoma Y, Yamashita M, Kamitani K, Nakagawa H. [Anti-inflammatory effects of methylprednisolone aceponate in animals]. Nihon Yakurigaku Zasshi. 1991 Nov;98(5):409-17. Japanese. doi: 10.1254/fpj.98.5_409. PMID: 1813371. 5: Tanaka M, Hiroshige R, Murai M, Tokunaga H, Okada S, Kimura T. [Diflucortolone-21-valerate Reference Standard (Control 871) of National Institute of Hygienic Sciences]. Eisei Shikenjo Hokoku. 1989;(107):156-9. Japanese. PMID: 2636922. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.09 ml | 10.448 ml | 20.896 ml |
5 mM | 0.418 ml | 2.09 ml | 4.179 ml |
10 mM | 0.209 ml | 1.045 ml | 2.09 ml |
5 mM | 0.042 ml | 0.209 ml | 0.418 ml |
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