39262-14-1
人参皂苷CK(Compound K)
CAS: 39262-14-1
化学式: C36H62O8
| 中文名 | 人参皂苷CK |
| 英文名 | Compound K |
| 别名 | 化合物 K 人参皂苷CK S-人参皂苷C-K 人参皂苷CK对照品, 人参皂苷 K, 来源于人参 20(S)-人参皂苷 C-K COMPOUND K 人参皂苷CK 人参皂苷CK(20(S)-人参皂苷CK S-人参皂苷CK,人参皂苷C-K,人参皂苷K,20 人参皂苷CK(20(S)-人参皂苷CK,人参皂苷C-K,人参皂苷K,20(S)-人参皂苷C-K) |
| 英文别名 | IH-901 Compound K Ginsenoside CK GINSENOSIDE COMPOUND K(P) 20(S)-Protopanaxadiol 20-O-D-glucopyranoside (20S)-20-O-β-D-Glucopyranosylprotopanaxadiol 20-(β-D-Glucopyranosyloxy)dammar-24-ene-3β,12β-diol 20-(β-D-Glucopyranosyloxy)-5α-dammara-24-ene-3β,12β-diol (20S)-20-(β-D-Glucopyranosyloxy)dammara-24-ene-3β,12β-diol b-D-Glucopyranoside, (3b,12b)-3,12-dihydroxydaMMar-24-en-20-yl |
| CAS | 39262-14-1 |
| 化学式 | C36H62O8 |
| 分子量 | 622.88 |
| 密度 | 1.19 |
| 熔点 | 181～183℃ |
| 沸点 | 723.1±60.0 °C(Predicted) |
| 比旋光度 | (c, 1 in MeOH)+39 |
| 溶解度 | 溶于DMSO,吡啶，不溶于石油醚、氯仿等有机溶剂。 |
| 酸度系数 | 12.94±0.70(Predicted) |
| 存储条件 | 2-8℃ |
| 外观 | 白色粉末 |
| 物化性质 | 白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于人参根茎，绞股蓝。 |
| MDL号 | MFCD07772261 |
| 体外研究 | Ginsenoside C-K, a bacterial metabolite of G-Rb1, exhibits anti-inflammatory effects mainly by reducing inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, and proinflammatory cytokines. Ginsenoside C-K suppresses the expression of proinflammatory cytokines by downregulating the activities of IRAK-1, MAPKs, IKK-α, and NF-κB in LPS-treated murine peritoneal macrophages. Ginsenoside C-K also suppresses the expression of iNOS and COX-2 by inhibiting NF-κB signaling in LPS-stimulated RAW264.7 cells. In zymosan-treated bone-marrow-derived macrophages (BMDMs) and RAW264.7 cells, Ginsenoside C-K inhibits inflammatory responses by negatively regulating the secretion of proinflammatory cytokines, the activation of MAPKs, and the generation of ROS. In addition, anti-inflammatory activity of Ginsenoside C-K has been observed in LPS-stimulated microglial cells. Ginsenoside C-K hinders inflammatory responses by controlling both the generation of ROS and the activities of MAPKs, NF-κB, and AP-1. Ginsenoside C-K, a major metabolite of ginsenosides in the gastrointestinal tract, inhibits NF-κB signaling in a PXR-dependent manner. Ginsenoside C-K is shown to promote recovery of dextran sulfate sodium (DSS) -induced colitis by suppressing NF-κB activation. Ginsenoside C-K significantly reduces TNF-α-induced upregulation of IL-1β and iNOS mRNA levels, and restores the mRNA levels of PXR and CYP3A4 in LS174T cells. Ginsenoside C-K, one of the intestinal metabolites of 20(S)-protopanaxadiol derivatives, exhibits an inhibition against the activity of CYP2C9 in human liver microsomes with an IC 50 value of 32.0±3.6 μM, a weak inhibition against the activity of CYP2A6 in human liver microsomes with an IC 50 value of 63.6±4.2 μM, and an even weaker inhibition against the activity of CYP2D6 in human liver microsomes with an IC 50 value of more than 100 μM. |
| 体内研究 | The weight of the collagen-induced arthritis (CIA) mice increases slowly and is significantly less than that of the normal DBA/1 mice beginning on d 3 after injection of the emulsion. Ginsenoside C-K (28, 56, and 112 mg/kg) mice recover their weight by d 32 after the emulsion injection. Ginsenoside C-K (56 and 112 mg/kg) and Methotrexate (MTX)-treated (2 mg/kg) mice show significantly increased body weight on d 50 as compared with CIA mice. Hind paw-swelling began on d 24 post-immunization. CIA mice are treated from d 28 to d 50. Arthritis scores are measured every 4 d beginning on d 24. Ginsenoside C-K (56 and 112 mg/kg) significantly reduces the arthritis scores of the mice on d 51. |
| 参考资料 展开查看 | 1. 陈佳欣 闫岩 张学武 等. 人参皂苷CK抑制STAT3诱导人肝癌细胞凋亡的内质网应激作用机制的研究[J]. 时珍国医国药 2020年31卷4期 796-799页 PKU CSCD CA 2020. 2. 孟雪 邱智东 王蕾 等. 人参皂苷CK抑制人结肠癌SW480细胞增殖的机制研究[J]. 中草药 2020(6). 3. 魏群 张璇 张学武.人参皂苷CK诱导人肝癌SMMC-7721细胞凋亡的内质网应激作用机制[J].时珍国医国药 2018 29(12):2896-2899. 4. 杨伟 滕林 丁家望 等. 人参皂苷compound K对小鼠心肌梗死后心室重构的保护及免疫机制研究[J]. 心肺血管病杂志 2016 35(006):478-481. 5. 方磊,陈红,余晓斌.高转化人参皂苷菌株筛选鉴定及发酵培养基优化[J].食品与发酵工业,2017,43(04):147-151. 6. 钟雅婷 茅仁刚 宋纯清 等. RP-HPLC同时测定西洋参总皂苷转化产物中人参皂苷Rg1 Rh1 Rd Rg3和C-K的含量[J]. 江西中医药 2012 43(8):61-64. 7. 韩铭鑫, 李方彤, 张琰,等. 稀有原人参二醇型皂苷的人肠道菌群生物转化[J]. 高等学校化学学报, 2019, 40(7). 8. 李雪晴, 李丽, 刘秀峰,等. 三七皂苷的人肠道菌群体外代谢研究[J]. 药物生物技术, 2017(03):34-39. 9. 夏晚霞, 张尚微, 葛亚中,等. 乳酸菌发酵转化人参皂苷[J]. 现代食品科技, 2018, 34(09):136-142. 10. 陈佳欣,闫岩,苏杰琳,赵嘉琪,张学武.人参皂苷Compound K通过Bcl-2相关转录因子1诱导人肝癌细胞SMMC-7721自噬的作用[J].延边大学医学学报,2020,43(03):157-161. 11. 陈佳欣,闫岩,张学武,张洪江.人参皂苷Compound K通过调控AKT/mTOR通路诱导人肝癌细胞自噬作用的研究[J].时珍国医国药,2020,31(06):1347-1350. 12. 赵彩秀,王楠,黄鑫,越皓,郭云龙,刘淑莹.枯草芽孢杆菌JLGA-SD-28转化人参皂苷Rb1的特性及其全基因组测序分析[J].中成药,2021,43(02):518-523. 13. Zhang, Xuan, et al. "Compound K induces endoplasmic reticulum stress and apoptosis in human liver cancer cells by regulating STAT3." Molecules 23.6 (2018): 1482.https://doi.org/10.3390/molecules23061482 14. Han, Xin, et al. "Biocatalytic production of compound K in a deep eutectic solvent based on choline chloride using a substrate fed-batch strategy." Bioresource technology 305 (2020): 123039.https://doi.org/10.1016/j.biortech.2020.123039 15. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu,A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 16. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu,A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 17. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu,A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 18. Joo, Kyung-Mi, et al. "Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/mass spectrometric method." Journal of pharmaceutical and biomedical analysis 51.1 (20 19. [IF=6.06] Jiahong Han et al."Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis."J Ginseng Res. 2020 Mar;44:291 20. [IF=5.34] Shan-Shan Zhou et al."Stronger anti-obesity effect of white ginseng over red ginseng and the potential mechanisms involving chemically structural/compositional specificity to gut microbiota."Phytomedicine. 2020 Aug;74:152761 21. [IF=4.952] Jiali Chen et al."Ginsenosides and amino acids in flavored ginseng chips as affected by food formulation and processing technology."Lwt Food Sci Technol. 2015 Jun;62:517 22. [IF=4.36] Bin Ma et al."Sulfur fumigation reducing systemic exposure of ginsenosides and weakening immunomodulatory activity of ginseng."J Ethnopharmacol. 2017 Jan;195:222 23. [IF=3.935] Hong-Mei Zhang et al."Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS/MS-based metabolomics approach."J Pharmaceut Biomed. 2012 Mar;62:258 24. [IF=3.935] Hong Zhang et al."A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry for the analysis of ginsenosides from white a 25. [IF=3.935] Shan-Shan Zhou et al."Synchronous characterization of carbohydrates and ginsenosides yields deeper insights into the processing chemistry of ginseng."J Pharmaceut Biomed. 2017 Oct;145:59 26. [IF=3.06] Xuan Zhang et al."Compound K Induces Endoplasmic Reticulum Stress and Apoptosis in Human Liver Cancer Cells by Regulating STAT3."Molecules. 2018 Jun;23(6):1482 27. [IF=9.642] Xin Han et al."Biocatalytic production of compound K in a deep eutectic solvent based on choline chloride using a substrate fed-batch strategy."Bioresource Technol. 2020 Jun;305:123039 28. [IF=6.023] Chenfei Li et al."Elucidation of interaction between serum albumin and ginsenoside CK along with cytotoxic study."Food Chem Toxicol. 2021 Sep;155:112403 29. [IF=5.396] Hui Wang et al."Ginsenoside extract from ginseng extends lifespan and health span in Caenorhabditis elegans."Food Funct. 2021 Aug;12(15):6793-6808 30. [IF=3.978] Weina Li et al."Ginsenoside CK production by commercial snailase immobilized onto carboxylated chitosan-coated magnetic nanoparticles."Biochem Eng J. 2021 Oct;174:108119 31. [IF=3.21] Ma Zhu et al."Transformation of ginsenoside via deep eutectic solvents based on choline chloride as an enzymatic reaction medium."Bioproc Biosyst Eng. 2020 Jul;43(7):1195-1208 32. [IF=2.629] Zhang Meiyu et al."In Vitro Transformation of Protopanaxadiol Saponins in Human Intestinal Flora and Its Effect on Intestinal Flora."Evid-Based Compl Alt. 2021;2021:1735803 33. [IF=2.055] Qian Chen et al."Shenyan Kangfu tablet alleviates diabetic kidney disease through attenuating inflammation and modulating the gut microbiota."J Nat Med-Tokyo. 2021 Jan;75(1):84-98 34. [IF=1.632] Wu Song et al."Ginsenoside compound K inhibits oxidative stress and NLRP3 inflammasome activity in mice exposed to chronic unpredictable mild stress."Biotechnol Biotec Eq. 2019;33(1):1372-1379 35. [IF=4.432] Shuai Zhang et al."Ginsenoside Rf inhibits human tau proteotoxicity and causes specific LncRNA, miRNA and mRNA expression changes in Caenorhabditis elegans model of tauopathy."Eur J Pharmacol. 2022 May;922:174887 36. [IF=2.419] Yinping Jin et al."Dynamic changes of ginsenosides in Panax quinquefolius fruit at different development stages measured by UHPLC-Orbitrap MS."Rapid Communications In Mass Spectrometry. 2022 Feb 17 |
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产品名: 人参皂苷CK(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IG01601
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产品名: 20(S)-人参皂苷 C-K 询盘CAS: 39262-14-1
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包装: 10mg；1g；250mg；25mg；100mg；50mg；5mg；1mg；200mg；2mg；1mL*10mM(inDMSO)；20mg；1mLx10mM(inDMSO)
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产品描述: 20(S)-人参皂苷 C-K，99%；99.65%，Amole/阿摩尔
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产品名: Ginsenoside C-K 去供应商网站查看 询盘CAS: 39262-14-1
产地: 美国
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提供多种规格现货供应
产品名: 人参皂苷CK(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IG01601
产地: 北京
包装: 1ml/瓶
规格: IG01601-1ml
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 18101056239(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 18101056239
产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
现货供应
产品名: 20(S)-人参皂苷 C-K 询盘CAS: 39262-14-1
产地: 上海
包装: 10mg；1g；250mg；25mg；100mg；50mg；5mg；1mg；200mg；2mg；1mL*10mM(inDMSO)；20mg；1mLx10mM(inDMSO)
规格: 99%；99.65%
价格: 电话、微信、QQ、邮件
库存: 现货
电话: 400-968-2212
手机: 18916960931
电子邮件: 3623107365@qq.com
QQ: 3623107365
微信: 18916960931
产品描述: 20(S)-人参皂苷 C-K，99%；99.65%，Amole/阿摩尔
提供多种规格现货供应
产品名: Ginsenoside C-K 去供应商网站查看 询盘CAS: 39262-14-1
产地: 美国
包装: 询盘
规格: HY-N0904R
价格: 询价
库存: 询盘
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度:
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