34367-04-9
人参皂苷Ro(1-O-[(5xi,9xi,18alpha)-3-{[2-O-(beta-D-glucopyranosyl)-beta-D-glucopyranuronosyl]oxy}-28-oxoolean-12-en-28-yl]-beta-D-glucopyranose)
CAS: 34367-04-9
化学式: C48H76O19
| 中文名 | 人参皂苷Ro |
| 英文名 | 1-O-[(5xi,9xi,18alpha)-3-{[2-O-(beta-D-glucopyranosyl)-beta-D-glucopyranuronosyl]oxy}-28-oxoolean-12-en-28-yl]-beta-D-glucopyranose |
| 别名 | 竹节参苷V 人参皂苷Ro 人参皂苷RO 竹节参皂苷V 人参皂苷RO对照品, 人参皂苷RO(标准品) 人参皂苷RO(分析标准品) |
| 英文别名 | LogP Ginsenosidero GinsenosideRo PolysciasaponinP3 ChikusetsusaponinV Chikusetsusaponin 5 28-(β-D-Glucopyranosyloxy)-28-oxoolean-12-en-3β-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranosiduronic acid 3β-(2-O-β-D-Glucopyranosyl-β-D-glucopyranuronosyloxy)oleana-12-ene-28-oic acid 28-β-D-glucopyranosyl ester 28-(β-D-Glucopyranosyloxy)-28-oxo-5α-olean-12-en-3β-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranosiduronic acid β-D-Glucopyranosiduronic acid, (3β)-28-(β-D-glucopyranosyloxy)-28-oxoolean-12-en-3-yl2-O-β-D-glucopyranosyl- (3beta)-28-(beta-D-Glucopyranosyloxy)-28-oxoolean-12-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranosiduronic acid 1-O-[(5xi,9xi,18alpha)-3-{[2-O-(beta-D-glucopyranosyl)-beta-D-glucopyranuronosyl]oxy}-28-oxoolean-12-en-28-yl]-beta-D-glucopyranose |
| CAS | 34367-04-9 |
| 化学式 | C48H76O19 |
| 分子量 | 957.11 |
| InChI | InChI=1/C48H76O19/c1-43(2)14-16-48(42(61)67-40-35(58)31(54)29(52)24(20-50)63-40)17-15-46(6)21(22(48)18-43)8-9-26-45(5)12-11-27(44(3,4)25(45)10-13-47(26,46)7)64-41-37(33(56)32(55)36(65-41)38(59)60)66-39-34(57)30(53)28(51)23(19-49)62-39/h8,22-37,39-41,49-58H,9-20H2,1-7H3,(H,59,60)/t22-,23-,24-,25?,26?,27?,28-,29-,30+,31+,32+,33+,34-,35-,36+,37-,39+,40+,41-,45+,46-,47-,48+/m1/s1 |
| 密度 | 1.14 |
| 熔点 | 239-241°C |
| 沸点 | 1018.6±65.0 °C(Predicted) |
| 比旋光度 | (c, 1 in MeOH)+15.3 |
| 闪点 | 289.2°C |
| 蒸汽压 | 0mmHg at 25°C |
| 溶解度 | 易溶于水、甲醇、乙醇，不溶于乙醚、苯。 |
| 折射率 | 1.627 |
| 酸度系数 | 2.76±0.70(Predicted) |
| 存储条件 | 2-8℃ |
| 敏感性 | Easily absorbing moisture |
| 外观 | 白色结晶粉末 |
| 物化性质 | 白色粉末，易溶于甲醇乙醇，来源于人参。 |
| MDL号 | MFCD01732056 |
| 体外研究 | Ginsenoside Ro in Panax ginseng is a beneficial novel Ca 2+ -antagonistic compound and may prevent platelet aggregation-mediated thrombotic disease. Ginsenoside Ro dose-dependently reduces thrombin-stimulated platelet aggregation, and IC 50 is approximately 155 μM. Ginsenoside Ro inhibits TXA 2 production to abolish thrombin-induced platelet aggregation. Thromboxane A 2 (TXA 2 ) induces platelet aggregation and promotes thrombus formation. Ginsenoside Ro dose-dependently (50-300 μM) reduces the TXB 2 level that is induced by thrombin; Ginsenoside Ro (300 μM) inhibits the thrombin-mediated elevation in TXB 2 level by 94.9%. COX-1 activity in the absence of Ginsenoside Ro (negative control) is 2.3±0.1 nmol/mg protein. However, Ginsenoside Ro dose-dependently (50-300 μM) reduces its activity; at 300 μM, COX-1 activity is reduced by 26.4% of that of the negative control. TXA 2 synthase (TXAS) activity in the absence of Ginsenoside Ro (negative control) is 220.8±1.8 ng/mg protein/min. However, Ginsenoside Ro dose-dependently (50-300 μM) reduces its activity; at 300 μM, TXAS activity is reduced by 22.9% of that of the negative control. The inhibitory effect of Ginsenoside Ro (300 μM) on TXB 2 production (94.9%) is significantly higher than those on COX-1 (26.4%) and TXAS (22.9%) activities. To assess the toxicity of Ginsenoside Ro in Raw 264.7 cells, they are first treated with various concentrations (10 μM, 50 μM, 100 μM, and 200 μM) of Ginsenoside Ro for 24 h. Ginsenoside Ro exhibits no significant dose dependent toxicity. The effect of Ginsenoside Ro is next determined on cell viability and ROS levels, a marker of oxidative stress, following treatment with 1 μg/mL LPS. LPS reduces cell viability by ∼70% compared with nontreated controls. Pretreatment with 100 μM and 200 μM Ginsenoside Ro for 1 h prior to 1 μg/mL LPS incubation for 24 h leads to a significant increase in cell viability. The changes in ROS levels and NO production are consistent with the effects of Ginsenoside Ro on viability. |
| 体内研究 | Ginsenoside Ro dissolved in water is administrated by gavage to mice at doses of 25 and 250 mg/kg/day for 4 days before i.v. injection of HT29 in order to keep blood concentrations of Ginsenoside Ro above a certain level before HT29 i.v. injection followed by 40 days of oral administration of Ginsenoside Ro to the mice. After 38 days of treatment, the animals are euthanized, and the number of pulmonary metastatic nodules is counted in addition to evaluation of toxicity of Ginsenoside Ro and mouse pathology by HT29. Ginsenoside Ro (250 mg/kg/day) produces a significant decrease in the number of tumor nodules on the lung surface, yielding inhibition rates of 88% (P [4] . |
| 海关编号 | 29389090 |
| 参考资料 展开查看 | 1. 宁张弛 刘振丽 宋志前 等. HPLC-QqQ-MS测定珠子参中5种皂苷类成分的含量[J]. 中国中药杂志 2016 v.41(05):874-878. 2. 曲胜军 沈晓庆 张凡 林桂梅 贾天柱.不同人参炮制品中5种人参皂苷的含量研究[J].亚太传统医药 2013 9(01):34-36. 3. 李金花, 冯有龙, 张再平,等. 多指标正交试验优化美国洋参胶囊中9种人参皂苷类成分测定的前处理方法[J]. 中南药学, 2017, 015(012):1757-1760. 4. 钱玲, 郑一文, 林影,等. 毕赤酵母表面展示麦芽三糖生成酶全细胞催化制备麦芽三糖[J]. 食品科技, 2020(5):1-7. 5. 梁献葵, 雷敬卫, 龚海燕,等. 牛膝指纹图谱分析[J]. 中国实验方剂学杂志, 2019(19). 6. 何家乐,周思思,马增春,梁乾德,王宇光,谭洪玲,肖成荣,汤响林,高月.基于UPLC-Q-TOF/MS研究参附注射液的物质基础[J].中国药理学通报,2014,30(03):429-433. 7. 吴冬雪,刘淑莹,陈思键,赵幻希,修洋,王淑敏.固相萃取结合高效液相色谱-三重四极杆质谱快速分离检测益气养血口服液中人参皂苷的新方法[J].分析测试学报,2020,39(07):867-873. 8. 张维方,梁献葵,纪亮,雷敬卫,龚海燕,唐维维,杨春静.不同品种牛膝3个成分含量测定及HPLC指纹图谱研究[J].时珍国医国药,2020,31(11):2665-2669 9. Joo, Kyung-Mi, et al. "Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/mass spectrometric method." Journal of pharmaceutical and biomedical analysis 51.1 (20 10. Joo, Kyung-Mi, et al. "Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/mass spectrometric method." Journal of pharmaceutical and biomedical analysis 51.1 (20 11. Wang, Xiaoping, et al. "Baoyuan decoction ameliorates apoptosis via AT1-CARP signaling pathway in H9C2 cells and heart failure post-acute myocardial infarction rats." Journal of ethnopharmacology 252 (2020): 112536.https://doi.org/10.1016/j.jep.2019.112536 12. [IF=6.06] Yang Xiu et al."Simultaneous determination and difference evaluation of 14 ginsenosides in Panax ginseng roots cultivated in different areas and ages by high-performance liquid chromatography coupled with triple quadrupole mass spectrometer in the multipl 13. [IF=5.34] Shan-Shan Zhou et al."Stronger anti-obesity effect of white ginseng over red ginseng and the potential mechanisms involving chemically structural/compositional specificity to gut microbiota."Phytomedicine. 2020 Aug;74:152761 14. [IF=4.36] Bin Ma et al."Sulfur fumigation reducing systemic exposure of ginsenosides and weakening immunomodulatory activity of ginseng."J Ethnopharmacol. 2017 Jan;195:222 15. [IF=3.978] Hongfei Yu et al."The effect of triterpenoid saponins on pancreatic lipase in vitro: Activity, conformation, kinetics, thermodynamics and morphology."Biochem Eng J. 2017 Sep;125:1 16. [IF=3.935] Shan-Shan Zhou et al."Synchronous characterization of carbohydrates and ginsenosides yields deeper insights into the processing chemistry of ginseng."J Pharmaceut Biomed. 2017 Oct;145:59 17. [IF=6.558] Qingqing Song et al."Binary code, a flexible tool for diagnostic metabolite sequencing of medicinal plants."Anal Chim Acta. 2019 Dec;1088:89 18. [IF=5.396] Hui Wang et al."Ginsenoside extract from ginseng extends lifespan and health span in Caenorhabditis elegans."Food Funct. 2021 Aug;12(15):6793-6808 19. [IF=5.34] You-Ping Wu et al."Evidences for the mechanism of Shenmai injection antagonizing doxorubicin-induced cardiotoxicity."Phytomedicine. 2021 Jul;88:153597 20. [IF=4.142] Wang Chenxi et al."Rapid discovery of potential ADR compounds from injection of total saponins from Panax notoginseng using data-independent acquisition untargeted metabolomics."Analytical And Bioanalytical Chemistry. 2021 Oct 26 21. [IF=3.69] Xiaoping Wang et al."Baoyuan decoction ameliorates apoptosis via AT1-CARP signaling pathway in H9C2 cells and heart failure post-acute myocardial infarction rats."J Ethnopharmacol. 2020 Apr;252:112536 22. [IF=3.361] Yuhao Zhang et al."An integrated approach for structural characterization of Gui Ling Ji by traveling wave ion mobility mass spectrometry and molecular network."Rsc Adv. 2021 Apr;11(26):15546-15556 23. [IF=2.629] Zhang Meiyu et al."In Vitro Transformation of Protopanaxadiol Saponins in Human Intestinal Flora and Its Effect on Intestinal Flora."Evid-Based Compl Alt. 2021;2021:1735803 24. [IF=2.419] Yinping Jin et al."Dynamic changes of ginsenosides in Panax quinquefolius fruit at different development stages measured by UHPLC-Orbitrap MS."Rapid Communications In Mass Spectrometry. 2022 Feb 17 25. [IF=5.279] He Zhang et al."De Novo Biosynthesis of Oleanane-Type Ginsenosides in Saccharomyces cerevisiae Using Two Types of Glycosyltransferases from Panax ginseng."J Agr Food Chem. 2022;XXXX(XXX):XXX-XXX 26. [IF=14.919] 27. [IF=5.811] He Zhang et al."Prevention Effect of Protopanaxadiol-Type Saponins Saponins and Protopanaxatriol-Type Saponins on Myelosuppression Mice Induced by Cyclophosphamide.."Frontiers in Pharmacology. 2022 Apr;13:845034-845034 |
34367-04-9 - 简介
人参皂苷Ro是从人参根的提取物中获得的一种活性成分，其化学结构为二萜类三萜皂苷。人参皂苷Ro具有多种生物活性，包括抗氧化、抗炎、抗肿瘤、抗衰老等作用。
它被广泛应用于中药治疗中，作为一种重要的中草药成分，具有调节免疫系统、改善血液循环、增强机体抗疲劳能力等功效。人参皂苷Ro还常用于保健品的生产中，作为抗衰老、提高抵抗力、增强记忆力等方面的功能性成分。
人参皂苷Ro的制法主要是从人参根中提取获得。通常的提取方法包括热水提取、超声波提取、超临界流体萃取等。
人参皂苷Ro的安全信息：目前尚未发现其对人体的明显毒副作用。个别人群可能存在对人参皂苷Ro过敏的情况，故在使用过程中需小心，注意个体差异。
它被广泛应用于中药治疗中，作为一种重要的中草药成分，具有调节免疫系统、改善血液循环、增强机体抗疲劳能力等功效。人参皂苷Ro还常用于保健品的生产中，作为抗衰老、提高抵抗力、增强记忆力等方面的功能性成分。
人参皂苷Ro的制法主要是从人参根中提取获得。通常的提取方法包括热水提取、超声波提取、超临界流体萃取等。
人参皂苷Ro的安全信息：目前尚未发现其对人体的明显毒副作用。个别人群可能存在对人参皂苷Ro过敏的情况，故在使用过程中需小心，注意个体差异。
最后更新：2024-04-09 21:54:55
供应商列表
提供多种规格现货供应
产品名: 人参皂苷Ro(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IG02901
产地: 北京
包装: 1ml/瓶
规格: IG02901-1ml
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 18101056239(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 18101056239
产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
提供多种规格现货供应
产品名: Ginsenoside Ro 去供应商网站查看 询盘CAS: 34367-04-9
产地: 美国
包装: 10 mM * 1 mL;5 mg;10 mg
规格: HY-N0607
库存: 现货，货期：1-2天
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: 99.81%
提供多种规格现货供应
产品名: 人参皂苷Ro(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IG02901
产地: 北京
包装: 1ml/瓶
规格: IG02901-1ml
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 18101056239(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 18101056239
产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
提供多种规格现货供应
产品名: Ginsenoside Ro 去供应商网站查看 询盘CAS: 34367-04-9
产地: 美国
包装: 10 mM * 1 mL;5 mg;10 mg
规格: HY-N0607
库存: 现货，货期：1-2天
电话: 021-38924433; 021-58955995
手机: 18019480960
电子邮件: sales@medchemexpress.cn
产品描述: 产品覆盖：8万多种抑制剂，11000+靶点蛋白，数百款试剂盒，200+生物活性化合物库，天然产物，抗体等. 纯度: 99.81%
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