1395946-75-4
APX-115(APX-115)
CAS: 1395946-75-4
化学式: C17H18ClN3O
| 中文名 | APX-115 |
| 英文名 | APX-115 |
| 别名 | 化合物 T10354 |
| 英文别名 | APX-115 Ewha-18278 |
| CAS | 1395946-75-4 |
| 化学式 | C17H18ClN3O |
| 分子量 | 315.8 |
| 存储条件 | -20°C，密封，干燥 |
| 体外研究 | APX-115 (5 μM; 60 min) almost completely suppresses high glucose-induced proinflammatory and profibrotic molecule expression in the mouse podocyte cell line. In the kidney, APX-115 attenuates Nox gene upregulation and protein expression while improving inflammatory and fibrotic processes. |
| 体内研究 | APX-115 (oral gavage; 60 mg/kg/day; for 12 weeks) significantly improves insulin resistance in diabetic mice. APX-115 treatment decreases the urinary excretion of albumin and plasma creatinine levels. Animal Model: Six-week-old male diabetic db/db mice (C57BLKS/J- lepr db /lepr db ) Dosage: 60 mg/kg Administration: Oral gavage; per day; for 12 weeks Result: Significantly improved insulin resistance in diabetic mice. |
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