118525-40-9
淫羊霍苷(3,5,7-Trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one)
CAS: 118525-40-9;38226-86-7
化学式: C21H20O6
| 中文名 | 淫羊霍苷 |
| 英文名 | 3,5,7-Trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one |
| 别名 | 淫羊霍苷 淫羊藿黄素 三七淫羊藿素 去水淫羊藿黄素 脱水淫羊藿黄素 淫羊藿素(标准品) ANHYDROICARITIN 脱水淫羊藿素 ANHYDROICARITIN 脱水淫羊藿素 标准品 |
| 英文别名 | ICARITIN icaritin Icaritin Cycloicaritin Anhydroicaritin b-Anhydroicaritin Icaritin, b-anhydro- Icaritin(Anhydroicaritin) 3,7-bis(2-hydroxyethyl)icaritin 3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one 3,5,7-Trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one 3,5,7-Trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one 4H-1-Benzopyran-4-one,3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)- 4H-1-benzopyran-4-one, 3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)- |
| CAS | 118525-40-9 38226-86-7 |
| 化学式 | C21H20O6 |
| 分子量 | 368.38 |
| InChI | InChI=1/C21H20O6/c1-11(2)4-9-14-15(22)10-16(23)17-18(24)19(25)20(27-21(14)17)12-5-7-13(26-3)8-6-12/h4-8,10,22-23,25H,9H2,1-3H3 |
| InChIKey | TUUXBSASAQJECY-UHFFFAOYSA-N |
| 密度 | 1.359 |
| 熔点 | 239℃ |
| 沸点 | 582.0±50.0 °C(Predicted) |
| 闪点 | 206.7℃ |
| 蒸汽压 | 3.82E-14mmHg at 25°C |
| 溶解度 | DMSO: 可溶5mg/mL，澄清 (温热) |
| 折射率 | 1.656 |
| 酸度系数 | 6.44±0.40(Predicted) |
| 存储条件 | 2-8°C |
| 外观 | 粉末 |
| 颜色 | light yellow to dark yellow |
| 最大波长(λmax) | 368nm(MeOH)(lit.) |
| 物化性质 | 黄色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于淫羊藿。 |
| MDL号 | MFCD22422519 |
| 体外研究 | Icaritin (4-64 µM; 48 hours; K562, imatinib-resistant cells and primary CML cells) treatment inhibits proliferation of K562, imatinib-resistant cells and primary CML cells . Icaritin (0-64 µM; 48 hours; K562 and primary cells) treatment induces K562 or primary cells apoptosis in an concentration dependent manner. Icaritin (32 µM; K562 cells) treatment increases cell population in the sub-G1 phase in K562 cells. Icaritin (0-64 µM; 48 hours; K562 cells) treatment inhibits MAPK/ERK/JNK downstream signaling and diminishes Jak2/Stat3/Akt expression. Icaritin treatment also significantly inhibits Bcl-2 protein expression and up-regulated Bax protein expression in K562 with a dose-dependent manner accompanied by the cleavage activation of caspase-3 or caspase-9, and a down-regulated expression of Apaf-1. Cell Proliferation Assay Cell Line: K562, imatinib-resistant cells and primary CML cells Concentration: 4 µM, 8 µM, 16 µM, 32 µM and 64 µM Incubation Time: 48 hours Result: Inhibited cell proliferation. Apoptosis Analysis Cell Line: K562 or primary cells Concentration: 0 µM, 4 µM, 8 µM, 16 µM, 32 µM and 64 µM Incubation Time: 48 hours Result: Induced K562 or primary cells apoptosis. Cell Cycle Analysis Cell Line: K562 cells Concentration: 32 µM Incubation Time: Result: Cell population in the sub-G1 phase was increased. Western Blot Analysis Cell Line: K562 cells Concentration: 0 µM, 4 µM, 8 µM, 16 µM, 32 µM and 64 µM Incubation Time: 48 hours Result: Inhibited MAPK/ERK/JNK downstream signaling and diminishes Jak2/Stat3/Akt expression. |
| 体内研究 | Icaritin (4-8 mg/kg; intraperitoneal injection; daily; for 10 weeks; female NOD-SCID nude mice) treatment could prolong lifespan of NOD-SCID nude mice inoculated with K562 cells without suppression of bone marrow in mouse leukemia model. Animal Model: Female NOD-SCID nude mice (6-8 weeks old) with K562 cells Dosage: 4 mg/kg and 8 mg/kg Administration: Intraperitoneal injection; daily; for 10 weeks Result: Could prolong lifespan of NOD-SCID nude mice inoculated with K562 cells without suppression of bone marrow. |
| WGK Germany | 3 |
| RTECS | DJ3100870 |
| 海关编号 | 29329990 |
| 上游原料 | 淫羊藿次苷I |
| 下游产品 | 8-异戊烯基山奈酚 |
| 参考资料 展开查看 | 1. 屠书梅,刘玉萍,陈彦.淫羊藿素抑制外泌体介导的黑色素瘤肺转移及机制初探[J].药学学报,2021,56(03):778-785. 2. Pan, Xiu-Wu, et al. "Icaritin acts synergistically with epirubicin to suppress bladder cancer growth through inhibition of autophagy." Oncology reports 35.1 (2016): 334-342.https://doi.org/10.3892/or.2015.4335 3. Cheng, Tao, et al. "Comparative pharmacokinetics study of icariin and icariside II in rats." Molecules 20.12 (2015): 21274-21286.https://doi.org/10.3390/molecules201219763 4. Liu, Congyan, et al. "Icariin combined with snailase shows improved intestinal hydrolysis and absorption in osteoporosis rats." Biomedicine & Pharmacotherapy 94 (2017): 1048-1056.https://doi.org/10.1016/j.biopha.2017.07.163 5. [IF=5.878] Shumei Tu et al."Icaritin ameliorates extracellular microparticles-induced inflammatory pre-metastatic niche via modulating the cGAS-STING signaling."Phytotherapy Research. 2022 Mar 07 |
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产品名: 脱水淫羊藿素 紫外分光标准品 去供应商网站查看 询盘CAS: 118525-40-9
产地: 北京
包装: 10mg /瓶
规格: SVA1215-10mg
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电话: 010-50973130
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产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
提供多种规格
产品名: 脱水淫羊藿素 紫外分光标准品 去供应商网站查看 询盘CAS: 118525-40-9
产地: 北京
包装: 10mg /瓶
规格: SVA1215-10mg
价格: 电话、微信、QQ、邮件
电话: 010-50973130
手机: 18101056239(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 18101056239
产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
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