109770-29-8_化工百科

中文名	H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH
英文名	H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH
别名	Β淀粉样蛋白(1-28) AMYLOID Β肽(1-28) Β淀粉样肽(1-28)单克隆抗体 Β-淀粉样蛋白 AMYLOID Β-PROTEIN (1-28)
英文别名	SP28 Β-AMYLOID (1-28) BETA-AMYLOID (1-28) DAEFRHDSGYEVHHQKLVFFAEDVGSNK amyloid B-protein fragment 1-28 BETA-AMYLOID PEPTIDE [1-28], HUMAN ALZHEIMER'S DISEASE Β-PROTEIN (SP28) BETA-AMYLOID (1-28), N-TERMINAL UNLABELED ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH
CAS	109770-29-8
化学式	C145 H209 N41 O46
分子量	3262.46
密度	1.52±0.1 g/cm3(Predicted)
存储条件	−20°C
外观	白色冻干粉。
体外研究	β-Amyloid Aggregation Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs). 1. Solid Aβ peptide was dissolved in cold hexafluoro-2-propanol (HFIP). The peptide was incubated at room temperature for at least 1h to establish monomerization and randomization of structure. 2. The HFIP was removed by evaporation, and the resulting peptide was stored as a film at -20 or -80 ℃. 3. The resulting film was dissolved in anhydrous DMSO at 5 mM and then diluted into the appropriate concentration and buffer (serum- and phenol red-free culture medium) with vortexing. 4. Next, the solution was age 48h at 4-8 ℃. The sample was then centrifuged at 14000g for 10 min at 4-8 ℃; the soluble oligomers were in the supernatant. The supernatant was diluted 10-200-fold for experiments.
体内研究	β-Amyloid (1-28) fragment is considered as valid models to examine the contribution of the key histidine residues (His , His in mouse and His , His , His in human fragments) to the Ab–Cu 2+ interaction. Copper binds to β-Amyloid (1-28) at pH 7.4 with an affinity of K a 10 7 M -1 .
WGK Germany	3

109770-29-8 - 简介

H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH是一种多肽，也被称为肽链。它由各种氨基酸残基组成，具有特定的结构和性质。

这个多肽的结构序列为：Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-OH。它具有多肽链的特点，包括天然氨基酸的官能团（如羧基、氨基、芳香环等）以及各氨基酸之间的肽键。

制备H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH的方法包括化学合成和生物合成两种。化学合成通常采用固相合成方法，通过逐步反应将各个氨基酸残基连接在一起，最后通过适当的修饰来得到目标多肽。生物合成则利用生物体内的基因工程技术，通过转基因菌或其他表达系统来表达目标多肽。

安全信息：H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH是一种多肽，它的安全性评估通常与具体的应用和用途有关。在使用前，需要进行相关的毒性和兼容性评估，并遵循适当的实验室操作规程和注意事项。另外，严禁将此多肽用于人体内部或其他生物体内，除非经过严格的临床研究和批准。

最后更新：2024-04-09 21:04:16

上海阿摩尔生物科技有限公司

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产品名: BETA-AMYLOID (1-28) 询盘
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MedChemExpress

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CAS: 109770-29-8
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