AMY-101 MedChemExpress (MCE)

Product Name	Compstatin analog peptide CP40
Synonyms	AMY-101 Compstatin 40 Compstatin analog peptide CP40 H-D-TYR-ILE-CYS-VAL-TRP(ME)-GLN-ASP-TRP-SAR-ALA-HIS-ARG-CYS-N-ME-ILE-NH2 L-Isoleucinamide, D-tyrosyl-L-isoleucyl-L-cysteinyl-L-valyl-1-methyl-L-tryptophyl-L-glutaminyl-L-α-aspartyl-L-tryptophyl-N-methylglycyl-L-alanyl-L-histidyl-L-arginyl-L-cysteinyl-N2-methyl-, cyclic (3→13)-disulfide
CAS	1427001-89-5
EINECS
Chemical Formula	C83H117N23O18S2
Molecular Weight	1789.11
inchi
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Descriptions	AMY-101 AMY-101 MedChemExpress (MCE) HY-P1717 1427001-89-5 Cp40 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions AMY-101 AMY-101 MedChemExpress (MCE) HY-P1717 1427001-89-5 Cp40 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. AMY-101 (Cp40), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation. AMY-101 can improve the periodontal condition of NHPs with natural chronic periodontitis[1]. AMY-101 can induce a long-lasting anti-inflammatory effect[1]. AMY-101 (4 mg/kg bodyweight, subcutaneous injection. once per 24 hr for a total of 28 days) causes a significant and long-lasting reduction in PPD, an index that measures tissue destruction[1]. AMY-101 (Cp40, 1 mg/kg, sc, injection every 12 h, daily, 7 or 14 days) attenuates fibrosis and infiltration of inflammatory cells in UUO-induced renal fibrosis[3]. KD: 0.5 nM (C3)[1]. In Vivo AMY-101 can improve the periodontal condition of NHPs with natural chronic periodontitis[1]. AMY-101 can induce a long-lasting anti-inflammatory effect[1]. AMY-101 (4 mg/kg bodyweight, subcutaneous injection. once per 24 hr for a total of 28 days) causes a significant and long-lasting reduction in PPD, an index that measures tissue destruction[1]. AMY-101 (Cp40, 1 mg/kg, sc, injection every 12 h, daily, 7 or 14 days) attenuates fibrosis and infiltration of inflammatory cells in UUO-induced renal fibrosis[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Fifteen adult male cynomolgus monkeys (Macaca fascicularis) (7-15 years old 5.0-7.6 kg body weight)[1]. {D-Tyr}-Ile-Cys-Val-{Trp(Me)}-Gln-Asp-Trp-{Sar}-Ala-His-Arg-Cys-{N(Me)Ile}-NH2 (Disulfide bridge:Cys3-Cys13) \| \| \| \| \| \| \| \| \| \| [1]. Kajikawa T, et al. Safety and Efficacy of the Complement Inhibitor AMY-101 in a Natural Model of Periodontitis in Non-human Primates. Mol Ther Methods Clin Dev. 2017 Aug 18 6:207-215. [Content Brief] [2]. Mastaglio S, et al. The first case of COVID-19 treated with the complement C3 inhibitor AMY-101. Clin Immunol. 2020 Apr 29:108450 [Content Brief] [3]. Yanyan Liu, et al. Complement C3 Produced by Macrophages Promotes Renal Fibrosis via IL-17A Secretion. Front Immunol. 2018 Oct 22 9:2385. [Content Brief]
Supplier Website	https://www.medchemexpress.com/amy-101.html
Last Update	2025-05-21 16:50:25

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