Hyodeoxycholic acid sodium MedChemExpress (MCE)

Product Name	hyodeoxycholic acid sodium
Synonyms	SODIUM HYODEOXYCHOLATE hyodeoxycholic acid sodium Hyodeoxycholic acid sodium salt Sodium 3α,6α-dihydroxy-5β-cholan-24-oate (3alpha,6alpha)-3,6-dihydroxycholan-24-oic acid 3α,6α-Dihydroxy-5β-cholan-24-oic acid sodium salt Synonyms SODIUM HYODEOXYCHOLATE hyodeoxycholic acid sodium Hyodeoxycholic acid sodium salt Sodium 3α,6α-dihydroxy-5β-cholan-24-oate (3alpha,6alpha)-3,6-dihydroxycholan-24-oic acid 3α,6α-Dihydroxy-5β-cholan-24-oic acid sodium salt 5BETA-CHOLAN-24-OIC ACID-3ALPHA,6ALPHA-DIOL SODIUM SALT 3ALPHA,6ALPHA-DIHYDROXY-5BETA-CHOLAN-24-OIC ACID SODIUM SALT 3,6-dihydroxy-,monosodiumsalt,(3alpha,5beta,6alpha)-cholan-24-oicaci sodium (3alpha,5beta,6alpha,8xi,9xi,14xi)-3,6-dihydroxycholan-24-oate 3α,6α-Dihydroxy-5β-cholan-24-oic acid, Hyodeoxycholic acid sodium salt
CAS	10421-49-5
EINECS	1806241-263-5
Chemical Formula	C24H39NaO4
Molecular Weight	414.55
inchi	InChI=1/C24H40O4.Na/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2 /h14-21,25-26H,4-13H2,1-3H3,(H,27,28) /q +1/p-1/t14-,15-,16?,17-,18?,19?,20+,21+,23-,24- inchi InChI=1/C24H40O4.Na/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2 /h14-21,25-26H,4-13H2,1-3H3,(H,27,28) /q +1/p-1/t14-,15-,16?,17-,18?,19?,20+,21+,23-,24- /m1./s1
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Descriptions	Hyodeoxycholic acid sodium Hyodeoxycholic acid sodium MedChemExpress (MCE) HY-N0169A 10421-49-5 HDCA sodium Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Hyodeoxycholic acid sodium Hyodeoxycholic acid sodium MedChemExpress (MCE) HY-N0169A 10421-49-5 HDCA sodium Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Hyodeoxycholic acid sodium is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC50 of 31.6 µM in CHO cells. Hyodeoxycholic acid sodium is a secondary hydrophilic bile acid formed in the small intestine by the gut flora, and acts as an agonist of TGR5, with an EC50 of 31.6 μM in CHO cells[1]. Hyodeoxycholic acid (50, 100 μM) sodium increases the expression of genes (Abca1, Abcg1, and Apoe) involved in cholesterol efflux in RAW 264.7 cells[2]. Hyodeoxycholic acid (HDCA 1.25% (wt/wt)) sodium obviously decreases fat mass and increases lean mass but does not raise the serum levels of any organ toxicity markers in LDLRKO mice. Hyodeoxycholic acid inhibits atherosclerotic lesion formation in LDLRKO at multiple sites, improves plasma lipoprotein profiles, decreases plasma glucose level and intestinal cholesterol absorption efficiency and increases daily cholesterol excretion through fecal output. Hyodeoxycholic acid sodium also improves HDL function as measured by a cholesterol efflux assay[2]. Microbial Metabolite Human Endogenous Metabolite \| \| \| \| \| \| \| \| \| \| [1]. Sato H, et al. Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J Med Chem. 2008 Mar 27 51(6):1831-41. [Content Brief] [2]. Shih DM, et al. Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice. FASEB J. 2013 Sep 27(9):3805-17. [Content Brief]
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Last Update	2025-05-21 16:50:25

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