Sevirumab MedChemExpress (MCE)

Product Name	EV2-7
Synonyms	EV2-7
CAS	138660-96-5
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Descriptions	Sevirumab Sevirumab MedChemExpress (MCE) HY-P99900 138660-96-5 MSL-109 Please store the product under the recommended conditions in the Certificate of Analysis. Sevirumab (MSL-109) is a human IgG1 neutralizing monoclonal antibody against cytomegalovirus (CMV). Sevirumab recognizes CMV gH complexes and inhibits CMV replication with an EC50 of 0.3 μg/mL. Sevirumab (MSL-109) perturbs the gH/gL homodimer rather than abolishing dimerization. Sevirumab may be splaying the dimer apart at sufficient distance to reduce fluorescence resonance energy transfer (FRET) and ultimately prevent proper gH/gL function[2]. EC50: 0.3 μg/mL (CMV)[1] In Vitro Sevirumab (MSL-109) perturbs the gH/gL homodimer rather than abolishing dimerization. Sevirumab may be splaying the dimer apart at sufficient distance to reduce fluorescence resonance energy transfer (FRET) and ultimately prevent proper gH/gL function[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Sevirumab Related Antibodies Human Human IgG1 kappa Human IgG1 kappa, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. Nokta M, et al. Human monoclonal anti-cytomegalovirus (CMV) antibody (MSL 109): enhancement of in vitro foscarnet- and ganciclovir-induced inhibition of CMV replication. Antiviral Res. 1994 May Descriptions Sevirumab Sevirumab MedChemExpress (MCE) HY-P99900 138660-96-5 MSL-109 Please store the product under the recommended conditions in the Certificate of Analysis. Sevirumab (MSL-109) is a human IgG1 neutralizing monoclonal antibody against cytomegalovirus (CMV). Sevirumab recognizes CMV gH complexes and inhibits CMV replication with an EC50 of 0.3 μg/mL. Sevirumab (MSL-109) perturbs the gH/gL homodimer rather than abolishing dimerization. Sevirumab may be splaying the dimer apart at sufficient distance to reduce fluorescence resonance energy transfer (FRET) and ultimately prevent proper gH/gL function[2]. EC50: 0.3 μg/mL (CMV)[1] In Vitro Sevirumab (MSL-109) perturbs the gH/gL homodimer rather than abolishing dimerization. Sevirumab may be splaying the dimer apart at sufficient distance to reduce fluorescence resonance energy transfer (FRET) and ultimately prevent proper gH/gL function[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Sevirumab Related Antibodies Human Human IgG1 kappa Human IgG1 kappa, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. Nokta M, et al. Human monoclonal anti-cytomegalovirus (CMV) antibody (MSL 109): enhancement of in vitro foscarnet- and ganciclovir-induced inhibition of CMV replication. Antiviral Res. 1994 May 24(1):17-26. [Content Brief] [2]. Fouts AE, et al. Mechanism for neutralizing activity by the anti-CMV gH/gL monoclonal antibody MSL-109. Proc Natl Acad Sci U S A. 2014 Jun 3 111(22):8209-14. [Content Brief]
Supplier Website	https://www.medchemexpress.com/sevirumab.html
Last Update	2025-05-21 16:50:25

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