Granuliberin R MedChemExpress (MCE)

Product Name	Granuliberin R
Synonyms	Granuliberin R GRANULIBERIN R FGFLPIYRRPAS-NH2 PHE-GLY-PHE-LEU-PRO-ILE-TYR-ARG-ARG-PRO-ALA-SER-NH2 H-PHE-GLY-PHE-LEU-PRO-ILE-TYR-ARG-ARG-PRO-ALA-SER-NH2 L-Phenylalanylglycyl-L-phenylalanyl-L-leucyl-L-prolyl-L-isoleucyl-L-tyrosyl-L-arginyl-L-arginyl-L-prolyl-L-alanyl-L-serinamide Synonyms Granuliberin R GRANULIBERIN R FGFLPIYRRPAS-NH2 PHE-GLY-PHE-LEU-PRO-ILE-TYR-ARG-ARG-PRO-ALA-SER-NH2 H-PHE-GLY-PHE-LEU-PRO-ILE-TYR-ARG-ARG-PRO-ALA-SER-NH2 L-Phenylalanylglycyl-L-phenylalanyl-L-leucyl-L-prolyl-L-isoleucyl-L-tyrosyl-L-arginyl-L-arginyl-L-prolyl-L-alanyl-L-serinamide L-Serinamide, L-phenylalanylglycyl-L-phenylalanyl-L-leucyl-L-prolyl-L-isoleucyl-L-tyrosyl-L-arginyl-L-arginyl-L-prolyl-L-alanyl-
CAS	64704-41-2
EINECS
Chemical Formula	C69H103N19O14
Molecular Weight	1422.68
inchi
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Descriptions	Granuliberin R Granuliberin R MedChemExpress (MCE) HY-P2706 64704-41-2 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Granuliberin R Granuliberin R MedChemExpress (MCE) HY-P2706 64704-41-2 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Granuliberin R is a new mast cell degranulating peptide comes from amphibian, can be isolated from the skin of frog Rana rugosa. Granuliberin R is a dodecapeptide, can act on rat peritoneal mast cell to liberate granules and release histamine. Granuliberin R (10 μg/mL) does not alter the release of catecholamines and adenine nucleotides from cultured adrenal chromaffin cells, while the Mastoparan (10 μg/mL) increases both of them[3]. Granuliberin R (0.1 mg/mL, 1 μg/mL, and 10 ng/mL injection single dose for 60 s) interfere in the proliferation of oral keratinocytes and the activity of connective tissue cells when treatment is conducted into rats mandibular gingiva in the vicinity of the right mental foramen[4]. \| \| \| \| \| \| \| \| \| \| [1]. Nakajima T, et al. A new mast cell degranulating peptide, granuliberin-R, in the frog (Rana rugosa) skin. Chem Pharm Bull (Tokyo). 1977 Sep 25(9):2464-5. [Content Brief] [2]. Yasuhara T, et al. The studies on the active peptide in the skin of Rana rugosa. II. The structure of ranatensin-R, the new ranatensin analogue, and granuliberin-R, the new mast cell degranulating peptide. Chem Pharm Bull (Tokyo). 1979 Feb 27(2):492-8. [Content Brief] [3]. Vitale N, et al. Exocytosis in chromaffin cells: evidence for a MgATP-independent step that requires a pertussis toxin-sensitive GTP-binding protein. Biochem J. 1994 May 15 300 ( Pt 1)(Pt 1):217-27. [Content Brief] [4]. Kozakiewicz M, et al. Modulation of the mitotic activity and population of the mast cells in the oral mucosa by substance P. Cell Mol Biol Lett. 2003 8(3):727-34. [Content Brief]
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Last Update	2025-04-01 14:45:47

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