Polygalacin D MedChemExpress (MCE)

Product Name	Polygalacin D
Synonyms	Onjisaponin D Polygalacin D Polygalacin D2 Olean-12-en-28-oic acid, 3-(β-D-glucopyranosyloxy)-2,16,23-trihydroxy-, O-D-apio-β-D-furanosyl-(1→3)-O-β-D-xylopyranosyl-(1→4)-O-6-deoxy-α-L-mannopyranosyl-(1→2)-α-L-arabinopyranosyl ester, (2β,3β,4β,16α)-
CAS	66663-91-0
EINECS
Chemical Formula	C57H92O27
Molecular Weight	1209.34
inchi
Package	1 mg;5 mg
Price	Get quote
Descriptions	Polygalacin D Polygalacin D MedChemExpress (MCE) HY-N6064 66663-91-0 99.95% 4°C, protect from light In solvent : -80°C, 6 months Descriptions Polygalacin D Polygalacin D MedChemExpress (MCE) HY-N6064 66663-91-0 99.95% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum with anticancer and anti-proliferative properties. PGD suppresses the expression of the IAP family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K. Polygalacin D induces apoptosis Polygalacin D (0-40 µM 48 hours) inhibits cell proliferation with IC50s of 26.49 µM in the A549 cells and 20.52 µM in the H460 cells[1]. Polygalacin D (0-20 µM 48 hours) increases the proportion of early and late apoptotic cells, and nuclear condensation is observed in A549 and H460 cells[1]. Polygalacin D (0-20 µM 48 hours) may exerts its apoptotic effects by regulating the apoptotic proteins and the IAP family of proteins in A549 and H460 cells[1]. IC50: IAP[1] Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Seo YS, et al. Polygalacin D induces apoptosis and cell cycle arrest via the PI3K/Akt pathway in non-small cell lung cancer. Oncol Rep. 2018 Apr 39(4):1702-1710. [Content Brief]
Supplier Website	https://www.medchemexpress.com/polygalacin-d.html
Last Update	2025-05-21 16:50:25

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