Smilagenin MedChemExpress (MCE)

Product Name	SMILAGENIN
Synonyms	SMILAGENIN;(25r)-spirostan-3β-ol;(25R)-SPIROSTAN-3BETA-OL;25R,5BETA-SPIROSTAN-3BETA-OL;5BETA,20ALPHA,22ALPHA,25D-SPIRANOSTAN-3BETA-OL;5-BETA, 20-ALPHA, 22-ALPHA, 25D-SPIROSTAN-3-BETA-OL
CAS	126-18-1
EINECS	204-775-8
Chemical Formula	C27H44O3
Molecular Weight	416.64
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Get quote
Descriptions	Smilagenin Smilagenin MedChemExpress (MCE) HY-106353 126-18-1 98.0% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Smilagenin Smilagenin MedChemExpress (MCE) HY-106353 126-18-1 98.0% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Smilagenin (SMI) is a small-molecule steroidal sapogenin from Anemarrhena asphodeloides and Pelargonium hortorum widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases. Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density. Smilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD. Smilagenin (10 μM 24 hours) increases SH-SY5Y cell survival compared with Aβ(25-35) intoxicated cells[3]. Smilagenin (10 μM 24 hours) increases neurotrophic factor (GDNF) and neurotrophic factor (BDNF) mRNA level by promoting CREB phosphorylation in 1-methyl-4-phenylpyridimium (MPP+) treated SH-SY5Y cells[2]. Smilagenin (intragastric administration 10 or 26 mg/kg, once daily 60 days) prevents the impairment of dopaminergic neurons in chronic MPTP/probenecid-induced mouse model[2]. mAChR1 \| \| \| \| \| \| \| \| \| \| [1]. He X, et al. Smilagenin Protects Dopaminergic Neurons in Chronic MPTP/Probenecid-Lesioned Parkinson's Disease Models. Front Cell Neurosci. 2019 Feb 5 13:18. [Content Brief] [2]. Hu Y, et al. Regulation of M1-receptor mRNA stability by smilagenin and its significance in improving memory of aged rats. Neurobiol Aging. 2010 Jun 31(6):1010-9. [Content Brief] [3]. Zhang R, et al. Smilagenin attenuates beta amyloid (25-35)-induced degeneration of neuronal cells via stimulating the gene expression of brain-derived neurotrophic factor. Neuroscience. 2012 May 17 210:275-85 [Content Brief]
Supplier Website	https://www.medchemexpress.com/smilagenin.html
Last Update	2025-05-21 16:50:25

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