DLin-KC2-DMA MedChemExpress (MCE)

Product Name	DLin-KC2-DMA
Synonyms	DLin-KC2-DMA;1,3-Dioxolane-4-ethanamine, N,N-dimethyl-2,2-di-(9Z,12Z)-9,12-octadecadien-1-yl-
CAS	1190197-97-7
EINECS
Chemical Formula	C43H79NO2
Molecular Weight	642.093
inchi
Package	5 mg;10 mg;25 mg;50 mg
Price	Get quote
Descriptions	DLin-KC2-DMA DLin-KC2-DMA MedChemExpress (MCE) HY-112758 1190197-97-7 99.88% -20°C, stored under nitrogen The compound is unstable in solutions, freshly prepared is recommended. Room temperature in continental US Descriptions DLin-KC2-DMA DLin-KC2-DMA MedChemExpress (MCE) HY-112758 1190197-97-7 99.88% -20°C, stored under nitrogen The compound is unstable in solutions, freshly prepared is recommended. Room temperature in continental US may vary elsewhere. DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies. DLin-KC2-DMA (1, 5 μg 72 h) effectively produces a significant siRNA-mediated GAPDH gene silencing in both macrophages and dendritic cells[1]. DLin-KC2-DMA (24 h) exhibits high uptake into macrophages and dendritic cells[1]. DLin-KC2-DMA efficiently promotes release of encapsulated siRNA into the cytosol following uptake via the endocytotic pathway[1]. DLin-KC2-DMA displays almost no toxicity in primary APCs[1]. DLin-KC2-DMA contained-LNP siRNA systems (5 mg/kg i.v. single) effectively silences target genes in APcs in vivo[1]. \| \| \| \| \| \| \| \| \| \| [1]. Basha G, et al. Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells. Mol Ther. 2011 Dec 19(12):2186-200. [Content Brief] [2]. Miller AD, et al. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov 10(6):781-811. [Content Brief]
Supplier Website	https://www.medchemexpress.com/DLin-KC2-DMA.html
Last Update	2025-05-21 16:50:25

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