TAK-599 hydrate; PPI0903 hydrate MedChemExpress (MCE)

Product Name	ceftaroline fosamil acetate monohydrate
Synonyms	TAK 599 acetate H2O ceftaroline fosamil acetate monohydrate 4-[2-[[(6R,7R)-2-carboxy-7-[[(2Z)-(ethoxyimino)[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]thio]-4-thiazolyl]-1-methylpyridinium acetate hydra Synonyms TAK 599 acetate H2O ceftaroline fosamil acetate monohydrate 4-[2-[[(6R,7R)-2-carboxy-7-[[(2Z)-(ethoxyimino)[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]thio]-4-thiazolyl]-1-methylpyridinium acetate hydra 4-[2-[[(6R,7R)-2-Carboxy-7-[[(2Z)-(ethoxyimino)[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]thio]-4-thiazolyl]-1-methylpyridinium acetate hydrate
CAS	400827-55-6
EINECS
Chemical Formula	C24H25N8O10PS4
Molecular Weight	744.72
inchi
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Descriptions	Ceftaroline fosamil hydrate Ceftaroline fosamil hydrate MedChemExpress (MCE) HY-14737A 400827-55-6 TAK-599 hydrate Descriptions Ceftaroline fosamil hydrate Ceftaroline fosamil hydrate MedChemExpress (MCE) HY-14737A 400827-55-6 TAK-599 hydrate PPI0903 hydrate Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Ceftaroline fosamil hydrate is a potent cephalosporin antibiotic. Ceftaroline fosamil hydrateshows broad-spectrum activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Streptococcus pneumoniae, and common Gram-negative organisms. Ceftaroline fosamil hydrate has anti-infective activity, and can be used for the research of complicated skin and skin structure infections (cSSSIs) and community-acquired bacterial pneumonia (CABP). Ceftaroline fosamil hydrate(s.c.) shows protective effects against experimental systemic infection caused by S. aureus N133 in mice, with ED50s of 1.60-2.37 mg/kg[1]. Ceftaroline fosamil hydrate (10 mg/kg s.c.) disappeares rapidly and converts smoothly into T-91825 in blood of rats and monkeys[1]. β-lactam \| \| \| \| \| \| \| \| \| \| [1]. Ishikawa T, et, al. TAK-599, a novel N-phosphono type prodrug of anti-MRSA cephalosporin T-91825: synthesis, physicochemical and pharmacological properties. Bioorg Med Chem. 2003 May 29 11(11):2427-37. [Content Brief] [2]. Biek D, et al. Ceftaroline fosamil: a novel broad-spectrum cephalosporin with expanded anti-Gram-positive activity. J Antimicrob Chemother. 2010 Nov 65 Suppl 4:iv9-16. [Content Brief] [3]. Parish D, et al. Ceftaroline fosamil, a cephalosporin derivative for the potential treatment of MRSA infection. Curr Opin Investig Drugs. 2008 Feb 9(2):201-9. [Content Brief]
Supplier Website	https://www.medchemexpress.com/ceftaroline-fosamil-hydrate.html
Last Update	2025-04-01 14:45:47

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